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Delivery of vinblastine-containing niosomes results in potent in vitro/in vivo cytotoxicity on tumor cells.

Author: AhmadvandHasan, AmiriBoshra, ChianiMohsen, FarhadiAli, NajmafsharAazam, NorouzianDariush

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Vinblastine (VB) is a cancer drug with limited use due to its poor water solubility, side effects, and drug resistance. This study created a PEGylated niosomal formulation of VB (Pn-VB), which showed improved stability, sustained release, and higher anti-cancer activity against lung cancer cells in mice compared to free VB.
Paper Details　
Original Abstract of the Article :
Vinblastine (VB), as a chemotherapeutic agent, is widely used in treatment of different types of cancer. However, its clinical application is limited due to its low water solubility, side effects, and multidrug resistance. The aim of this study was to increase the therapeutic efficacy of VB using dr...See full text at original site
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引用元：
https://doi.org/10.1080/03639045.2018.1451880

データ提供：米国国立医学図書館（NLM）

Delivery of Vinblastine-Containing Niosomes: A New Oasis in the Desert of Cancer Treatment

Cancer, a formidable desert of health challenges, requires innovative approaches to treatment. This study, like a team of researchers exploring the vast landscape of drug delivery systems, investigates the potential of niosomal formulations in enhancing the efficacy of vinblastine, a chemotherapy drug. The researchers, like skilled engineers, design and test a new drug delivery system, seeking to improve the delivery and effectiveness of vinblastine in combating cancer.

Navigating the Desert of Cancer Treatment: A New Route to Deliver Vinblastine

The study demonstrates that the PEGylated niosomal formulation of vinblastine (Pn-VB) exhibited superior cytotoxicity against lung cancer cells compared to free vinblastine. This is like discovering a new route through the desert, where Pn-VB, acting as a caravan carrying valuable cargo, effectively delivers the chemotherapy drug to its target. The study also found that Pn-VB showed a sustained release behavior, suggesting a more controlled and effective drug delivery system.

A New Oasis in Cancer Therapy: Enhancing Drug Delivery and Effectiveness

This research offers a promising avenue for improving cancer treatment. It highlights the potential of niosomal formulations to enhance drug delivery and effectiveness, potentially leading to better outcomes for patients. This is like finding a new oasis in the desert of cancer treatment, offering a source of hope and possibilities for more effective therapies.

Dr.Camel's Conclusion

This study presents a promising oasis in the desert of cancer treatment. The PEGylated niosomal formulation of vinblastine offers a more effective and targeted approach to drug delivery, potentially leading to better outcomes for patients battling this formidable disease.
Date :
  1. Date Completed 2018-10-10
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

29532687

DOI: Digital Object Identifier

10.1080/03639045.2018.1451880

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Article Analysis
・Side Effects of vinblastine
SNS
PICO Info
in preparation
Languages

English

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