A systematic review of adverse events of rifapentine and isoniazid compared to other treatments for latent tuberculosis infection.

Author: AlvarezGonzalo G, BarbeauPauline, HamelCandyce, HuttonBrian, PeaseChristopher, SkidmoreBecky, WolfeDianna, YazdiFatemeh

Paper Details 
Original Abstract of the Article :
Tuberculosis (TB) remains a common cause of death globally. A regimen of 12 doses of isoniazid (INH) and rifapentine given once weekly (INH/RPT-3) has recently been recommended by the World Health Organization for the treatment of latent TB infection (LTBI). We aimed to determine whether the INH/RPT...See full text at original site
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引用元:
https://doi.org/10.1002/pds.4423

データ提供:米国国立医学図書館(NLM)

Rifapentine and Isoniazid for Latent Tuberculosis Infection: A Systematic Review of Adverse Events

The global burden of tuberculosis, like a persistent drought in a once-thriving desert, continues to pose a significant threat to public health. This systematic review, like a team of researchers seeking a solution to a critical problem, investigates the safety profile of a new treatment regimen for latent tuberculosis infection (LTBI).

Evaluating a New Treatment Regimen: A Safety First Approach

The researchers compared the incidence of adverse events associated with a regimen of rifapentine and isoniazid given once weekly (INH/RPT-3) to other commonly used LTBI treatments. This study, like a carefully planned expedition across a challenging terrain, aims to determine whether this new regimen is a safe and effective option for patients with LTBI.

Prioritizing Safety in TB Treatment

This review underscores the importance of prioritizing safety in the treatment of tuberculosis. It highlights the need for careful evaluation of new treatment regimens and underscores the importance of considering both efficacy and safety when choosing the best course of treatment for individual patients. This study, like a compass guiding us through the complex landscape of TB treatment, reminds us to navigate with caution and choose the safest path possible.

Dr. Camel's Conclusion

This systematic review offers valuable insights into the safety profile of a new treatment regimen for latent tuberculosis infection. It emphasizes the importance of ongoing research to develop safe and effective treatments for this persistent global health challenge. By prioritizing safety and employing a rigorous research approach, we can work toward a future where TB is effectively controlled and its impact on human health is minimized, like a desert oasis flourishing amidst a challenging environment.

Date :
  1. Date Completed 2019-09-16
  2. Date Revised 2019-09-16
Further Info :

Pubmed ID

29573031

DOI: Digital Object Identifier

10.1002/pds.4423

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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