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The OPTIMA study, buprenorphine/naloxone and methadone models of care for the treatment of prescription opioid use disorder: Study design and rationale.

Author: AhamadKeith, BruneauJulie, FischerBenedikt, Jutras-AswadDidier, Le FollBernard, LimRon, SociasM Eugenia, WildT Cameron, WoodEvan

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Opioid use and opioid use disorder (OUD) are increasing in North America. Methadone and buprenorphine/naloxone are the recommended treatments for OUD. While buprenorphine/naloxone is considered safer, most research on OUD treatments has focused on heroin users and used strict dosing schedules. This study compares the effectiveness of buprenorphine/naloxone and methadone for treating prescription opioid use disorder (POUD) in real-world clinical settings.
Paper Details　
Original Abstract of the Article :
Rates of non-medical use of opioids, and opioid use disorders (OUD) have been rising throughout North America. Methadone and buprenorphine/naloxone are the recommended first-line treatment options for OUD in Canada. Most studies to date have been conducted among heroin users, in controlled settings,...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/29627621

データ提供：米国国立医学図書館（NLM）

Buprenorphine/Naloxone vs. Methadone: A Comparative Study for Prescription Opioid Use Disorder

This study investigates the [Relative effectiveness of buprenorphine/naloxone and methadone-based models of opioid agonist therapy (OAT)] for the treatment of [Prescription opioid use disorder (POUD)]. The study uses [A large-scale clinical trial (OPTIMA)] to compare [The outcomes of buprenorphine/naloxone and methadone treatment] in routine clinical care. The researchers aim to provide evidence to support [The choice of treatment for POUD based on real-world clinical practice]. This study is significant because [It will contribute to the development of evidence-based guidelines for treating POUD] and [It will help clinicians make informed decisions about the most appropriate treatment option for their patients].

Finding the Right Path for Opioid Use Disorder

The study's findings are expected to provide valuable insights into [The effectiveness and practicality of different OAT models] for treating POUD.

Navigating Opioid Use Disorder: A Collaborative Approach

This research emphasizes the importance of collaborating with healthcare providers to develop personalized treatment plans for opioid use disorder. Just as a camel relies on its caravan for support and guidance, we must also seek support from professionals to navigate the challenges of opioid addiction.

Dr. Camel's Conclusion

This study is a testament to the ongoing effort to improve treatment options for opioid use disorder. It highlights the importance of exploring different treatment approaches and developing evidence-based guidelines to ensure the best possible outcomes for patients. It's a reminder that we must continue to work together to combat this complex health issue and provide support and resources to those in need.
Date :
  1. Date Completed 2019-10-17
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

29627621

DOI: Digital Object Identifier

NIHMS1039731

Related Literature

Article Analysis
・Effective treatment of opioid use
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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