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Tizanidine and ibuprofen in acute low-back pain: results of a double-blind multicentre study in general practice.

Author: BerryH, HutchinsonD R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tizanidine, a muscle relaxant, was combined with ibuprofen for treating acute low-back pain. The combination showed greater effectiveness than ibuprofen alone, particularly in relieving night and rest pain. Tizanidine was also associated with fewer gastrointestinal side effects but more central nervous system effects.
Paper Details　
Original Abstract of the Article :
This study reports on 105 patients with acute low-back pain given tizanidine (4 mg three times daily) plus ibuprofen (400 mg three times daily) or placebo plus ibuprofen (400 mg three times daily). Patients assessed their pain using visual analogue scales in a daily diary and the doctor assessed the...See full text at original site
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引用元：
https://doi.org/10.1177/030006058801600202

データ提供：米国国立医学図書館（NLM）

Tizanidine and Ibuprofen: A Double-Blind Journey to Relieve Back Pain

Acute low-back pain is a common ailment that can significantly impact daily life. This research investigates the effectiveness of combining tizanidine, a muscle relaxant, and ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), in treating acute low-back pain. The study, a double-blind, multicenter trial, compares the combination therapy to placebo plus ibuprofen, seeking to determine the effectiveness of tizanidine in alleviating back pain. This is an important area of research, as it could provide clinicians with a more effective approach to treating this prevalent condition.

A New Path to Relief: Combining Medications for Optimal Outcomes

The study's findings suggest that the combination of tizanidine and ibuprofen is more effective in treating moderate or severe acute low-back pain than ibuprofen alone. The study highlights the potential benefits of combining medications, a strategy that could offer more comprehensive pain relief. Imagine a camel caravan facing a steep incline, finding it easier to navigate the terrain by combining the strength of multiple camels to pull the load. Similarly, combining medications can offer a more powerful and effective approach to treating pain.

A Balanced Approach: Navigating the Risks and Benefits

The study also highlights the potential side effects of tizanidine, including drowsiness and central nervous system effects. This underscores the importance of carefully weighing the risks and benefits of medication combinations, ensuring that the benefits outweigh any potential side effects. This is an important reminder to approach medical treatment with a balanced perspective, just as a camel caravan navigating a desert must consider the risks and rewards of each path.

Dr.Camel's Conclusion

This study explores the effectiveness of combining tizanidine and ibuprofen for treating acute low-back pain. The findings suggest that this combination therapy is more effective than ibuprofen alone, offering potentially improved pain relief. However, the study also highlights the importance of considering potential side effects and carefully weighing the risks and benefits of medication combinations.

Date :
  1. Date Completed 1988-07-22
  2. Date Revised 2017-02-14
Further Info :

Pubmed ID

2967781

DOI: Digital Object Identifier

10.1177/030006058801600202

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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