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PXR as a mediator of herb-drug interaction.

Author: FolanM Maggie, GuanXiudong, HogleBrett C, XieWen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article explores the role of the pregnane X receptor (PXR) in herb-drug interactions. PXR, a key transcriptional factor regulating xenobiotic responses, can lead to alterations in drug pharmacokinetic properties, potentially causing fluctuating therapeutic efficacies and complications. The article highlights the importance of understanding PXR-mediated interactions to mitigate potential risks in herbal medicine.
Paper Details　
Original Abstract of the Article :
Medicinal herbs have been a part of human medicine for thousands of years. The herb-drug interaction is an extension of drug-drug interaction, in which the consumptions of herbs cause alterations in the metabolism of drugs the patients happen to take at the same time. The pregnane X receptor (PXR) h...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326879/

データ提供：米国国立医学図書館（NLM）

PXR: A Gatekeeper in the World of Herb-Drug Interactions

The use of medicinal herbs, like a traditional caravan traversing ancient trade routes, is deeply ingrained in human history. However, the interplay between herbs and medications, like a delicate balance of spices in a complex recipe, can lead to unexpected consequences. This research delves into the role of the pregnane X receptor (PXR), a key player in drug metabolism, in mediating herb-drug interactions.

PXR: A Key Player in the Dance of Herbs and Drugs

The study highlights the crucial role of PXR in regulating the expression of enzymes and transporters involved in drug metabolism. PXR, like a watchful guardian at a desert oasis, can significantly influence the pharmacokinetic properties of drugs, potentially leading to altered therapeutic efficacy and even adverse reactions. Understanding the interplay between PXR and herbs is crucial for ensuring safe and effective drug interactions.

Navigating Herb-Drug Interactions: A Journey of Awareness

This research serves as a reminder of the importance of careful consideration when using herbs alongside medications. Individuals who incorporate herbs into their health regimens, like travelers navigating a complex desert landscape, should consult with their healthcare providers to ensure safe and effective drug interactions. By understanding the potential for herb-drug interactions, we can minimize the risk of adverse effects and maximize the benefits of both herbs and medications.

Dr. Camel's Conclusion

This research, like a wise camel traversing a desert of knowledge, sheds light on the intricate world of herb-drug interactions. By understanding the role of PXR in this delicate dance, we can navigate the potential risks and maximize the benefits of both herbs and medications, ensuring a smoother and safer journey for our health.

Date :
  1. Date Completed 2019-10-15
  2. Date Revised 2022-08-09
Further Info :

Pubmed ID

29703383

DOI: Digital Object Identifier

PMC9326879

Related Literature

Article Analysis
・Effective treatment of herbalism
SNS
PICO Info
in preparation
Languages

English

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