Effective treatment of herbalism: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Major Research Findings

Herbalism has been used successfully in treating various diseases for centuries. Recent studies have provided further evidence on its potential benefits. 3 suggests that polyphenols, particularly anthocyanins, found in temperate climate fruit-bearing plants, exhibit antidiabetic effects and could be valuable in managing diabetes and associated complications. 4 highlights the health benefits of wolfberry, a traditional Chinese medicine, for overall health and disease treatment. Another study, 5 , evaluated the efficacy of CartiNovex plus tablet in managing osteoarthritis and rheumatoid arthritis, finding it to be effective and well-tolerated. However, 6 emphasizes the importance of understanding herb-drug interactions, particularly those mediated by PXR, as they can potentially affect drug efficacy and safety. Other research suggests potential therapeutic benefits of herbalism for joint disorders, headache, and cancer. 9 , , 16

Benefits and Risks

Benefit Summary

Herbalism demonstrates potential for effectively treating various ailments like diabetes, joint disorders, headaches, and cancer. 3 , 9 , , 16 It also holds promise as a traditional Chinese medicine for overall health improvement and disease management. 4 Moreover, herbal remedies might offer lower risks of adverse effects and higher safety compared to conventional drugs. 5 , 9

Risk Summary

Herbalism can interact with conventional medications. 6 Certain herbs may cause adverse reactions or allergic responses. It is crucial to consult with a healthcare professional before using herbs.

Comparison between Studies

Commonalities among Studies

Numerous studies suggest that herbalism can be beneficial in treating a wide range of ailments. Additionally, they indicate that herbal remedies might be safer and have fewer side effects compared to conventional drugs.

Differences between Studies

Studies vary in the specific herbs they explore, the diseases they focus on, and the research methodologies and evaluation criteria employed. This makes it challenging to draw definitive conclusions about the effectiveness of herbalism.

Consistency and Contradictions in Results

While consistent findings support the potential benefits of herbalism, contradictions also exist. These inconsistencies might be attributed to variations in research methodologies and evaluation criteria. More research is needed to address these discrepancies.

Points to Note Regarding Real-Life Applications

When incorporating herbalism into daily life, it is essential to consider the following points: 1. Understand the correct type, dosage, and usage of herbs. 2. Consult a healthcare professional before using herbs. 3. Avoid using herbs during pregnancy, breastfeeding, or while ill. 4. Discontinue use and consult a doctor immediately if adverse reactions or allergies occur.

Limitations of Current Research

Research on herbalism is still insufficient. Further studies are required, particularly those focusing on the active ingredients, mechanisms of action, and safety of herbs.

Future Research Directions

To further advance research on herbalism, the following areas require investigation: 1. Studies on the active ingredients and mechanisms of action of herbs 2. Research on the safety of herbs 3. Clinical trials involving herbs 4. Studies on interactions between herbalism and conventional medications

Conclusion

Herbalism holds promise for treating a wide range of ailments. However, it is important to remember that herbalism can interact with conventional medications and might lead to adverse reactions or allergies. Caution is essential when incorporating herbalism into daily life. More research is needed to fully understand the benefits and risks of herbalism.

Literature analysis of 22 papers
Positive Content
18
Neutral Content
1
Negative Content
3
Article Type
3
1
0
7
21
2.

Differences in Serum Biomarkers Between Combined Glucosamine and Chondroitin Versus Celecoxib in a Randomized, Double-blind Trial in Osteoarthritis Patients.

Author: NavarroSandi L, HerreroMarta, MartinezHelena, ZhangYuzheng, LaddJon, LoEdward, ShelleyDavid, RandolphTimothy W, LampeJohanna W, LampePaul D

Anti-inflammatory effects
GH+CS
Inflammatory conditions treatment
Potential for joint pain relief
Safer alternative
Needs further research
Unclear effectiveness compared to NSAIDs

Glucosamine hydrochloride plus chondroitin sulfate (GH+CS) is a common supplement for joint pain. While non-steroidal anti-inflammatory drugs (NSAIDs) like celecoxib are also used for joint pain, they can have side effects. Research suggests that GH+CS may have anti-inflammatory properties, offering a potentially safer alternative to NSAIDs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

The Possibility of Using Fruit-Bearing Plants of Temperate Climate in the Treatment and Prevention of Diabetes.

Author: ŁysiakGrzegorz P, SzotIwona

Antidiabetic effect

This systematic review examines the antidiabetic effects of various fruit plants, highlighting the role of polyphenols, especially anthocyanins, in treating diabetes and associated complications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Health benefits of wolfberry (Gou Qi Zi, <i>Fructus barbarum</i> L.) on the basis of ancient Chineseherbalism and Western modern medicine.

Author: WenliSun, ShahrajabianMohamad Hesam, QiCheng

Disease treatment
Health promotion

Goji berry is a medicinal crop with valuable nutritional and bioactive properties used for thousands of years in Traditional Chinese Medicine. This study highlights its potential for promoting health, treating diseases, and providing industrial sustainability.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

To evaluate the efficacy and safety of CartiNovex plus tablet in osteoarthritis and rheumatoid arthritis.

Author: RiazAmir, DaniyalMuhammad, GhauriMuhammad Ishaq, AlamHamza, ZaidiSyed Faisal, UsmanghaniKhan, WangWei

Osteoarthritis treatment
Rheumatoid arthritis treatment
Side effects

CartiNovex plus tablet, a herbal medicine, shows significant improvement in pain, stiffness, and overall function in patients with osteoarthritis (OA) and rheumatoid arthritis (RA). This single-blind, placebo-controlled study found CartiNovex plus to be effective and well-tolerated, offering a potential alternative treatment option for arthritis.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

PXR as a mediator of herb-drug interaction.

Author: HogleBrett C, GuanXiudong, FolanM Maggie, XieWen

Adverse reactions
Herb-drug interaction

This article explores the role of the pregnane X receptor (PXR) in herb-drug interactions. PXR, a key transcriptional factor regulating xenobiotic responses, can lead to alterations in drug pharmacokinetic properties, potentially causing fluctuating therapeutic efficacies and complications. The article highlights the importance of understanding PXR-mediated interactions to mitigate potential risks in herbal medicine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

[Variety and distribution of Anhui native medicinal materials in ancient Chinese materia medica].

Author: XieJin, ZhaLiang-Ping, PengHua-Sheng, WangDe-Qun, PengDai-Yin

Chinese medicine utilization

Anhui province in China is rich in traditional Chinese medicine resources. This paper examines the historical usage of native medicinal materials in Anhui, highlighting the variety and distribution of medicinal plants across different geographical units. The study provides insights into the historical basis for the rich medicinal resources of the province and emphasizes the importance of protecting and utilizing these resources.

Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

8.

Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements.

Author: MurtazaGhulam, UllahNaveed, MukhtarFarah, NawazishShamyla, MuneerSaiqa,

Drug interaction

Botanical supplements, often perceived as safe, can interact with drug transport and metabolism, potentially affecting drug efficacy and safety. This paper explores the interaction of botanical supplement ingredients with drug transporters like P-gp and OATPs, highlighting the clinical significance of these interactions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Phytomedicine in Joint Disorders.

Author: DragosDorin, GilcaMarilena, GamanLaura, VladAdelina, IosifLiviu, StoianIrina, LupescuOlivera

Joint pain relief
Medicinal plants

This review summarizes the scientific information on the use of medicinal plants for chronic joint inflammatory disorders. While many medicinal plants have been shown to be effective in in vitro and animal studies, human clinical evidence is lacking. The review focuses on 11 plants tested in human studies: Arnica montana, Boswellia spp., Curcuma spp., Equisetum arvense, Harpagophytum procumbens, Salix spp., Sesamum indicum, Symphytum officinalis, Zingiber officinalis, Panax notoginseng, and Whitania somnifera.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Traditional medicine among people of Pakistani descent in the capital region of Copenhagen.

Author: RamzanSara, SoelbergJens, JägerAnna K, Cantarero-ArévaloLourdes

This qualitative study explored the use of traditional medicines among Pakistani immigrants in Denmark, highlighting the need for research on their impact on health-related problems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Pharmacological characteristics of Artemisia vulgaris L. in isolated porcine basilar artery.

Author: NguyenHa Thi Thanh, NguyenHai Thanh, IslamMd Zahorul, ObiTakeshi, PothinuchPitchaya, ZarPhyu Phyu Khine, HouDe Xing, Van NguyenThanh, NguyenTuong Manh, Van DaoCuong, ShiraishiMitsuya, MiyamotoAtsushi

Hypertension treatment uncertainty

This study investigates the conflicting opinions about the effect of Artemisia vulgaris L. (AVL) on hypertension in Vietnamese traditional herbalism. It aims to clarify the pharmacological characteristics of AVL in isolated arteries and provide a scientific explanation for the discrepancies in its use for treating hypertension.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

[USE OF COMPLEMENTARY AND ALTERNATIVE MEDICINE AMONG FAMILY MEDICINE PATIENTS--EXAMPLE OF THE TOWN OF ČAKOVEC].

Author: VitaleKsenija, MunđarRoko, SovićSlavica, Bergman-MarkovićBiserka, Janev HolcerNataša

CAM use
Overall health improvement
CAM side effects

This study investigated the use of complementary and alternative medicine (CAM) among family medicine patients in Croatia, finding that 82% of patients used some form of CAM, with herbs being the most common.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Croatian

13.

Inhibitory effect of ephedrannins A and B from roots of Ephedra sinica STAPF on melanogenesis.

Author: KimIk-Soo, YoonSung-Jin, ParkYoung-Jun, LeeHee-Bong

Melanogenesis regulation

Ephedrannins A and B, polyphenols from the roots of Ephedra sinica, showed inhibitory effects on mushroom tyrosinase and melanogenesis in B16F10 melanoma cells, suggesting potential applications in skin lightening treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Chinese medicines and bioactive compounds for treatment of stroke.

Author: JayakumarThanasekaran, ElizebethAntoinet Ramola, YenTing-lin, SheuJoen-rong

Stroke treatment

This review summarizes various Chinese medicines (CMs), bioactive compounds, and their effects on cerebral ischemia. The combination of thrombolytic therapy and effective neural protection therapy may be an alternative strategy for patients with cerebral ischemia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

The immunologic injury composite with balloon injury leads to dyslipidemia: a robust rabbit model of human atherosclerosis and vulnerable plaque.

Author: ZhangGuangyin, LiMing, LiLiangjun, XuYingzhi, LiPeng, YangCui, ZhouYanan, ZhangJunping

Atherosclerosis model

A new animal model for atherosclerosis has been developed using a combination of immunologic injury and balloon injury in cholesterol-fed white rabbits. This model could be valuable for studying the disease and testing new treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Artemisia absinthium (AA): a novel potential complementary and alternative medicine for breast cancer.

Author: ShafiGowhar, HasanTarique N, SyedNaveed Ahmed, Al-HazzaniAmal A, AlshatwiAli A, JyothiA, MunshiAnjana

Anticancer agent
Apoptosis promotion

Artemisia absinthium (AA) extract showed cytotoxic effects against human breast carcinoma cells, inducing apoptosis through modulation of Bcl-2 family proteins and the MEK/ERK pathway.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India.

Author: DuaVirendra K, VermaGaurav, AgarwalDau Dayal, KaiserMarcel, BrunReto

Protozoan parasite treatment
Malaria
Protozoan infections

This study investigates the potential of selected medicinal plants from the Garhwal region of the Himalayas for treating protozoal infections. Ethnopharmacological research aims to identify new plant-derived biologically active compounds.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Patient counseling about herbal-drug interactions.

Author: HussainMd Sarfaraj

Herb-drug interactions

This article discusses the potential risks of herb-drug interactions. Herbal medications, unlike synthetic drugs, often contain multiple active ingredients, which increases the likelihood of interactions with prescribed medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

[Study on geo-herbalism of Curcuma wenyujin based on ecological factors].

Author: WuZhi-Gang, TaoZheng-Ming, LengChun-Hong, PanYong-Di, ZhangJian, LinLi

Increased yields

Ecological factors significantly influence the yields and qualities of Curcuma wenyujin. Key factors include average temperature, high-temperature days, rainfall, altitude, and soil potassium content.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

20.

Mechanisms of treatment of cancer pain with a topical Chinese herbal formula in rats.

Author: YuShan, PengHai-dong, JuDa-wei, WeiPin-kang, XuLing, LaoLi-xing, LiJun

Cancer pain treatment
Bone cancer pain

This study evaluated the analgesic effects of Xiaotan Tongluo analgesic gel (XTTL gel), a topical herbal formula, in a rat model of bone cancer pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Traditional medicines used by Pakistani migrants from Mirpur living in Bradford, Northern England.

Author: PieroniAndrea, SheikhQaiser-Zain, AliWajid, TorryBren

Pakistani migrants in Bradford use herbal remedies, and further research is needed to understand their perceptions and use of traditional medicines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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