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Penehyclidine Hydrochloride Decreases Pulmonary Microvascular Endothelial Inflammatory Injury Through a Beta-Arrestin-1-Dependent Mechanism.

Author: LiuQiang-Sheng, WangYan-Lin, XiaoFei, YuanQing-Hong, ZhanJia, ZhangZong-Ze, ZhengFei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the protective effect of penehyclidine hydrochloride (PHC) on lipopolysaccharide (LPS)-induced inflammatory injury in cultured human pulmonary microvascular endothelial cells (HPMVEC). The results showed that PHC reduced inflammatory responses to LPS stimulation by increasing beta-arrestin-1 expression and inhibiting NF-κB activation. The study concludes that PHC exerts a protective effect on pulmonary microvascular endothelial inflammatory injury induced by LPS through its ability to upregulate beta-arrestin-1.
Paper Details　
Original Abstract of the Article :
Penehyclidine hydrochloride (PHC), a type of hyoscyamus drug, has both antimuscarinic and antinicotinic activities and retains potent central and peripheral anticholinergic activities. Compared with other hyoscyamine, the notable advantage of PHC is that it has few M<sub>2</sub> receptor-associated ...See full text at original site
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引用元：
https://doi.org/10.1007/s10753-018-0804-9

データ提供：米国国立医学図書館（NLM）

Penehyclidine Hydrochloride: A New Hope for Lung Injury?

Lung injury is like a desert storm, wreaking havoc on the respiratory system. This study focuses on penehyclidine hydrochloride (PHC), a drug with both antimuscarinic and antinicotinic activities, and explores its potential to protect the lungs from inflammatory injury. The researchers investigated the mechanisms by which PHC may exert its protective effects, providing new insights into the potential therapeutic benefits of this drug.

Penehyclidine Hydrochloride: A Potential Protective Agent

The study found that PHC effectively reduced inflammatory responses in cultured human pulmonary microvascular endothelial cells. The researchers found that PHC increased the expression of beta-arrestin-1, a protein that inhibits the activation of NF-κB, a key player in the inflammatory process. These findings suggest that PHC could potentially protect the lungs from inflammatory injury.

Finding Relief from Lung Injury

This study provides hope for patients with lung injury, suggesting that PHC could offer a new therapeutic approach to protect the lungs from inflammatory damage. It's like finding a hidden spring of water in the desert, providing a source of relief and healing.

Dr.Camel's Conclusion

This study suggests that penehyclidine hydrochloride may offer a new therapeutic approach to protect the lungs from inflammatory injury. The findings provide valuable insights into the potential mechanisms of action of this drug and highlight its potential therapeutic benefits.

Date :
  1. Date Completed 2019-01-02
  2. Date Revised 2019-01-02
Further Info :

Pubmed ID

29766401

DOI: Digital Object Identifier

10.1007/s10753-018-0804-9

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Languages

English

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