A Systematic Review on Donepezil-based Derivatives as Potential Cholinesterase Inhibitors for Alzheimer's Disease.

Author: BenekOndrej, JuzaRadomir, KapingDaniel, KorabecnyJan, MezeiovaEva, SoukupOndrej, SpilovskaKatarina

Paper Details 
Original Abstract of the Article :
Alzheimer's Disease (AD) is a multifactorial progressive neurodegenerative disorder characterized by memory loss, disorientation, and gradual deterioration of intellectual capacity. Its etiology has not been elucidated yet. To date, only one therapeutic approach has been approved for the treatment o...See full text at original site
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引用元:
https://doi.org/10.2174/0929867325666180517094023

データ提供:米国国立医学図書館(NLM)

Donepezil-based Derivatives: A Promising Avenue for Alzheimer's Disease Treatment

The search for effective treatments for Alzheimer's disease (AD), a devastating neurodegenerative disorder, continues to be a priority in the field of medicine. This research explores the potential of donepezil-based derivatives as potential cholinesterase inhibitors for AD. The authors meticulously review various donepezil-related compounds, assessing their efficacy as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), enzymes that play a crucial role in the breakdown of neurotransmitters. Think of it as a team of scientists meticulously sifting through a desert of potential compounds, seeking those with the power to combat the effects of Alzheimer's disease.

Hope for the Future of Alzheimer's Treatment

This research, like a rare desert flower blooming amidst the harsh conditions, offers a glimmer of hope for the future of Alzheimer's disease treatment. By exploring donepezil-based derivatives, researchers may be able to develop new and improved therapies that target the underlying mechanisms of this debilitating disease. This study provides a valuable foundation for future research, paving the way for more effective treatments and potentially even cures.

Understanding Alzheimer's Disease

Alzheimer's disease is a complex and multifaceted condition, like a vast desert with many hidden challenges. It's crucial to seek early diagnosis and support to manage the symptoms and slow the progression of the disease. Research like this, focused on developing new therapies, offers a ray of hope for those affected by Alzheimer's and their families.

Dr. Camel's Conclusion

This research is like a camel caravan trekking across a vast desert, searching for an oasis of hope for those battling Alzheimer's disease. By exploring the potential of donepezil-based derivatives, researchers may be able to unlock new pathways to effective treatment. It's a reminder that even in the face of seemingly insurmountable challenges, the pursuit of knowledge and innovation can lead to life-changing breakthroughs.

Date :
  1. Date Completed 2019-11-25
  2. Date Revised 2020-01-08
Further Info :

Pubmed ID

29768996

DOI: Digital Object Identifier

10.2174/0929867325666180517094023

Related Literature

SNS
PICO Info
in preparation
Languages

English

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