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A computational study of hedgehog signalling involved in basal cell carcinoma reveals the potential and limitation of combination therapy.
Author: Buetti-DinhAntoine, FriedmanRan, JensenRebecca
Original Abstract of the Article :
The smoothened (SMO) receptor is an essential component of the Sonic hedgehog (SHH) signalling, which is associated with the development of skin basal cell carcinoma (BCC). SMO inhibitors are indicated for BCC patients when surgical treatment or radiation therapy are not possible. Unfortunately, SMO...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960207/
データ提供:米国国立医学図書館(NLM)
Basal Cell Carcinoma: A Computational Journey into the Desert of Skin Cancer
Basal cell carcinoma (BCC), a common type of skin cancer, is like a persistent desert sandstorm that can impact the delicate skin of the body. This research delves into the intricate world of hedgehog signaling, a crucial pathway involved in BCC development. The study explores the potential and limitations of combination therapy for BCC treatment using SMO inhibitors.
The authors use computational modeling to analyze the interactions of various molecules within the hedgehog signaling pathway. They uncover the potential benefits of using SMO inhibitors in combination with other therapies, but also acknowledge the limitations of this approach. Imagine the hedgehog signaling pathway as a vast desert landscape, where different molecules interact in complex ways. The researchers are trying to map out this landscape and understand how to disrupt the growth of BCC cells.
Mapping the Desert of Skin Cancer
This research provides valuable insights into the mechanisms of BCC development and offers a new perspective on potential treatment strategies. By studying the intricate interactions within the hedgehog signaling pathway, researchers are gaining a deeper understanding of how to combat this type of skin cancer.
Protecting Your Skin: A Desert Oasis of Health
This research reminds us of the importance of protecting our skin from the sun's harmful rays. Regular skin checks and early detection are crucial in the fight against skin cancer.
Dr.Camel's Conclusion
This research is a testament to the power of computational modeling in understanding complex biological processes. It provides a promising roadmap for developing new and effective therapies for BCC. By understanding the intricate desert landscape of hedgehog signaling, researchers are getting closer to finding a cure for this common skin cancer.
Date :
- Date Completed 2019-01-10
- Date Revised 2019-12-10
Further Info :
Related Literature
English
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