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Clinical and laboratory investigation of the effects of epsilon-aminocaproic acid on hemostasis.

Author: AtkinsonA J, CerulloL, CohenI, GreenD, RuoT I, Ts'aoC H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Epsilon-aminocaproic acid (EACA) prolonged bleeding time in patients with intracranial aneurysms. A daily dose of 24 gm EACA, administered continuously for 72 hours, significantly impaired fibrinolysis, but normal fibrinolytic activity was observed within 72 hours of stopping the drug. EACA inhibited platelet aggregation and fibrinogen binding in vitro, but had little effect on platelet function in vivo.
Paper Details　
Original Abstract of the Article :
We previously reported that epsilon-aminocaproic acid (EACA) prolonged the bleeding time in patients with intracranial aneurysms when given in doses of 36 to 48 gm/day. We now show that doses of 24 gm/day also prolong the bleeding time, but only after 72 hours of continuous infusion. The effect on t...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2982982

データ提供：米国国立医学図書館（NLM）

Epsilon-aminocaproic Acid: A Journey Through the Desert of Hemostasis

The field of hematology is a complex and often challenging desert, with researchers constantly seeking to understand the intricate mechanisms of hemostasis. This study embarks on a journey to explore the effects of epsilon-aminocaproic acid (EACA) on hemostasis, investigating its impact on bleeding time and platelet function. The researchers conducted a series of experiments, investigating the effects of EACA on both in vitro and in vivo models. Their findings suggest that EACA may prolong bleeding time, potentially due to its effects on platelet aggregation and the platelet-vessel wall interaction. This research provides valuable insights into the complex interplay of factors influencing hemostasis, offering a glimpse into the hidden landscape of this critical physiological process.

Navigating the Desert of Hemostasis: Epsilon-aminocaproic Acid and Bleeding Time

The study found that EACA significantly prolonged bleeding time, suggesting that it may have a significant impact on hemostasis. This finding highlights the importance of considering the potential effects of EACA on bleeding time, particularly in patients undergoing procedures or experiencing conditions that may affect their clotting process.

Understanding the Desert: Epsilon-aminocaproic Acid and Hemostasis

This research offers a valuable perspective on the complex mechanisms of hemostasis, illustrating the potential impact of EACA on bleeding time and platelet function. By understanding the subtle interplay of factors influencing this vital process, clinicians can make informed decisions about medication use and manage potential risks associated with EACA therapy.

Dr. Camel's Conclusion

This research provides a valuable glimpse into the intricate workings of the hemostasis system, reminding us that the desert of hematology is filled with complex and often hidden pathways. By understanding the potential effects of medications like EACA, clinicians can navigate this complex terrain with greater precision and ensure the well-being of their patients.

Date :
  1. Date Completed 1985-04-19
  2. Date Revised 2018-02-06
Further Info :

Pubmed ID

2982982

DOI: Digital Object Identifier

0022-2143(85)90031-9

Related Literature

Article Analysis
・Effects of aminocaproic acid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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