Antiepileptic drugs as analgesics/adjuvants in inflammatory pain: current preclinical evidence.

Author: MicovAna, PecikozaUroš, Stepanović-PetrovićRadica, TomićMaja, VučkovićSonja

Paper Details 
Original Abstract of the Article :
Inflammatory pain is the most common type of pain that is treated clinically. The use of currently available treatments (classic analgesics - NSAIDs, paracetamol and opioids) is limited by insufficient efficacy and/or side effects/tolerance development. Antiepileptic drugs (AEDs) are widely used in ...See full text at original site
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引用元:
https://doi.org/10.1016/j.pharmthera.2018.06.002

データ提供:米国国立医学図書館(NLM)

Antiepileptic Drugs as Pain Relief Agents: Exploring New Horizons

[Inflammatory pain] is a common ailment that often presents a challenge for clinicians. This review delves into the potential of [antiepileptic drugs (AEDs)] as analgesics or adjuvants for managing [inflammatory pain]. The authors reviewed preclinical data on the efficacy of AEDs, focusing on [gabapentinoids and dibenzazepines], against various models of [somatic, visceral, and trigeminal inflammatory pain]. Their findings indicate that AEDs exhibit promising analgesic properties, comparable to [classic analgesics] but with potentially fewer side effects.

AEDs: A Potential Alternative for Managing Inflammatory Pain

This research provides compelling evidence that AEDs, particularly [gabapentinoids and dibenzazepines], could offer an effective alternative or adjunctive therapy for [inflammatory pain]. The review highlights the consistent analgesic activity of these drugs across different models of inflammatory pain, suggesting a broad potential for application. The findings also indicate that AEDs might be [more tolerable] than [classic analgesics], potentially paving the way for improved pain management strategies.

Navigating Pain Relief with AEDs: A Promising Future?

The potential of AEDs to effectively manage [inflammatory pain] is exciting. The review suggests that these drugs could offer a [safer and more effective] approach to pain relief. It's important to remember that [further clinical trials] are necessary to confirm these findings in human patients. However, this research opens up new avenues for exploration and development of [innovative pain management strategies] in the future.

Dr.Camel's Conclusion

This research is like a refreshing oasis in the vast desert of pain management. It reveals the potential of AEDs to effectively combat inflammatory pain, offering a promising avenue for relief. However, just like a camel navigating a desert, we must carefully evaluate the potential benefits and risks before embarking on this journey. Consult with your healthcare provider for personalized guidance.
Date :
  1. Date Completed 2019-09-23
  2. Date Revised 2019-09-23
Further Info :

Pubmed ID

29909236

DOI: Digital Object Identifier

10.1016/j.pharmthera.2018.06.002

Related Literature

SNS
PICO Info
in preparation
Languages

English

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