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New treatments and therapeutic targets for IBS and other functional bowel disorders.

Author: SimrénMagnus, TackJan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

New drugs targeting key mechanisms in the pathophysiology of functional bowel disorders (FBDs), such as lubiprostone, linaclotide, plecanatide, prucalopride, eluxadoline, and rifaximin, offer broader treatment options for the symptom complex. The development of new treatment alternatives is focused on various aspects of FBDs, including gut microenvironment, enterohepatic circulation of bile acids, gastrointestinal secretion, motility, and sensation.
Paper Details　
Original Abstract of the Article :
Functional bowel disorders (FBDs) are a spectrum of disorders characterized by combinations of symptoms attributable to the lower gastrointestinal tract. Most current first-line therapies for IBS and other FBDs target the predominant symptom and mainly affect one symptom in the symptom complex. Addi...See full text at original site
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引用元：
https://doi.org/10.1038/s41575-018-0034-5

データ提供：米国国立医学図書館（NLM）

Functional Bowel Disorders: A New Frontier in Treatment

This research explores the latest advancements in the treatment of functional bowel disorders (FBDs), including irritable bowel syndrome (IBS). Researchers delve into novel drug therapies targeting key mechanisms in the pathophysiology of FBDs and discuss emerging treatment strategies focusing on gut microbiome modulation, bile acid regulation, and gastrointestinal motility.

Targeting the Gut Microbiome: A New Era of Treatment

This study explores the exciting potential of personalized medicine and novel drug therapies in managing FBDs. Imagine a vast desert ecosystem, where a delicate balance between different species is essential for survival. This research suggests that targeting the gut microbiome and understanding its role in FBDs can lead to more personalized and effective treatment approaches.

Functional Bowel Disorders: A Journey Towards Better Management

This study provides a comprehensive overview of the latest developments in FBD treatment. By understanding the complex mechanisms underlying these disorders, researchers are developing targeted therapies that can effectively address the various symptoms and improve the quality of life for individuals with FBDs. This research highlights the importance of continued research and innovation in finding effective and personalized treatment solutions for FBDs.

Dr.Camel's Conclusion

This research offers a hopeful glimpse into the future of FBD treatment. Just as a camel adapts to the harsh desert environment, researchers are adapting their approaches to address the complexities of FBDs. The focus on personalized medicine, gut microbiome modulation, and novel drug therapies holds great promise for improving the lives of individuals living with these debilitating conditions.
Date :
  1. Date Completed 2019-07-15
  2. Date Revised 2019-07-15
Further Info :

Pubmed ID

29930260

DOI: Digital Object Identifier

10.1038/s41575-018-0034-5

Related Literature

Article Analysis
・Effects of eluxadoline・Effects of plecanatide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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