Effects of plecanatide: A Synthesis of Findings from 29 Studies

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This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

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Original Abstract of the Article

Major Research Findings

Plecanatide is an approved therapy for chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation. It is an analog of uroguanylin that replicates its pH-sensitive activity and binds to guanylate cyclase-C receptors expressed on intestinal epithelium, stimulating fluid secretion. 18 Plecanatide has shown significant efficacy in treating CIC, with improvements in constipation severity, straining, stool consistency, bowel movements, and quality of life. 23 22 Plecanatide has also been found to be safe and effective for treating CIC in patients aged 65 years or older. 21 The drug has also been shown to be effective and safe for treating irritable bowel syndrome with constipation (IBS-C). 29 It is generally considered a safe medication with a limited risk of serious side effects. 25

Benefits and Risks

Benefit Summary

Plecanatide can be effective in treating both chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). It is associated with improvements in bowel function, including increased stool frequency, softer stools, and reduced straining. It can also improve overall quality of life for patients experiencing constipation. 18 23 22 21 29

Risk Summary

The most common side effect of plecanatide is diarrhea. 23 22 25 21 29 This side effect is typically mild and manageable. 23 22 25 21 29 However, it's important to be aware of this potential side effect and discuss it with your doctor if you are considering using plecanatide. 23 22 25 21 29

Comparison of Studies

Commonalities

All reviewed studies concluded that plecanatide is effective in treating CIC and IBS-C. These studies demonstrated improvements in bowel function, reduced constipation severity, and enhanced quality of life for patients. 18 23 22 25 21 29

Differences

The studies varied in terms of patient population, evaluation methods, and specific outcomes measured. 18 23 22 25 21 29 Some studies focused on specific patient demographics, such as older adults, while others explored the drug's efficacy in broader patient populations. 21 Additionally, the specific measures used to assess constipation symptoms and the duration of treatment varied across studies. 18 23 22 25 21 29

Consistency and Contradictions in Findings

While the majority of the studies showed a consistent positive effect of plecanatide on constipation symptoms, the interpretation of these findings needs to consider the differences in patient populations and study designs. 18 23 22 25 21 29 The presence of differing inclusion criteria and methodological approaches across studies might lead to variations in the observed effects and necessitates cautious generalization of the findings. 18 23 22 25 21 29

Implications for Daily Life

While plecanatide has shown promise in treating CIC and IBS-C, it is important to remember that individual responses to medication can vary. 18 23 22 25 21 29 It is crucial to discuss your symptoms and concerns with your doctor and together determine if plecanatide is the right treatment option for you. 18 23 22 25 21 29

Limitations of Current Research

The studies reviewed here focused primarily on the short-term efficacy and safety of plecanatide. 18 23 22 25 21 29 Further research is needed to understand the long-term effects and potential risks associated with its use. 18 23 22 25 21 29

Future Research Directions

Longitudinal studies are needed to assess the long-term effects and safety of plecanatide. 18 23 22 25 21 29 Additionally, comparative studies that evaluate the efficacy and safety of plecanatide against other available constipation treatments are warranted. 18 23 22 25 21 29

Conclusion

The available research suggests that plecanatide is a promising treatment option for both CIC and IBS-C, offering significant benefits in terms of improved bowel function and quality of life. 18 23 22 25 21 29 However, it is crucial to be aware of the potential side effects, particularly diarrhea. 23 22 25 21 29 As with any medication, consulting with a healthcare professional is essential to determine if plecanatide is the right treatment option for your individual needs. 18 23 22 25 21 29

Literature analysis of 29 papers
Positive Content
28
Neutral Content
1
Negative Content
0
Article Type
13
6
7
13
29
1.

Effect of pneumococcal conjugate vaccine on nasopharyngeal colonization among immunized and unimmunized children in a community-randomized trial.

Author: O'BrienKatherine L, MillarEugene V, ZellElizabeth R, BronsdonMelinda, WeatherholtzRobert, ReidRaymond, BecentiJocelyn, KvammeSheri, WhitneyCynthia G, SantoshamMathuram

Reduces VT colonization
Increases NVT colonization

This study found that PnCRM7 reduced the risk of VT acquisition and colonization density but increased the risk of NVT acquisition among vaccinees and their household contacts.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

2.

Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian children who participated in a 9-valent pneumococcal conjugate vaccine trial and in their younger siblings.

Author: CheungYin-Bun, ZamanSyed M A, NsekpongEkpedeme David, Van BenedenChris A, AdegbolaRichard A, GreenwoodBrian, CuttsFelicity T

Antibiotic resistance reduction
Pneumococcal carriage reduction

The 9-valent pneumococcal conjugate vaccine (PCV-9) significantly reduced the carriage of vaccine serotypes in Gambian children for at least 16 months postvaccination. PCV-9 had no indirect effect on carriage in younger siblings and had a limited impact on antibiotic resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effect of reduced-dose schedules with 7-valent pneumococcal conjugate vaccine on nasopharyngeal pneumococcal carriage in children: a randomized controlled trial.

Author: van GilsElske J M, VeenhovenReinier H, HakEelko, RodenburgGerwin D, BogaertDebby, IjzermanEd P F, BruinJacob P, van AlphenLoek, SandersElisabeth A M

Reduced pneumococcal carriage
None reported

A 2 + 1-dose and 2-dose schedule of PCV-7 resulted in significant reductions of vaccine serotype pneumococcal carriage in the second year of life compared with no pneumococcal vaccination.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Comparing pneumococcal conjugate vaccine schedules based on 3 and 2 primary doses: systematic review and meta-analysis.

Author: ScottPippa, RutjesAnne W S, BermetzLilian, RobertNadège, ScottSusana, LourençoTania, EggerMatthias, LowNicola

High seropositivity
S. pneumoniae carriage reduction
Clinical relevance unknown

Both 3-dose and 2-dose pneumococcal conjugate vaccine (PCV) schedules resulted in high levels of seropositivity, with small differences favoring the 3-dose schedule. However, clinical outcome data from randomized controlled trials with direct comparisons of different PCV schedules is lacking.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Effects of community-wide vaccination with PCV-7 on pneumococcal nasopharyngeal carriage in the Gambia: a cluster-randomized trial.

Author: RocaAnna, HillPhilip C, TownendJohn, EgereUzo, AntonioMartin, BojangAbdoulie, AkisanyaAbiodun, LitchfieldTeresa, NsekpongDavid E, OluwalanaClaire, HowieStephen R C, GreenwoodBrian, AdegbolaRichard A

Pneumococcal disease prevention
Serotype replacement

PCV-7 vaccination was found to have an impact on pneumococcal carriage in rural Gambia, suggesting the potential for serotype replacement.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Effects of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugate vaccine on nasopharyngeal bacterial colonization in young children: a randomized controlled trial.

Author: van den BerghMenno R, SpijkermanJudith, SwinnenKristien M, FrançoisNancy A, PascalThierry G, BorysDorota, SchuermanLode, IjzermanEd P F, BruinJacob P, van der EndeArie, VeenhovenReinier H, SandersElisabeth A M

The 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) did not show a significant effect on nasopharyngeal NTHi colonization or H. influenzae density in healthy Dutch children up to 2 years of age.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Impact of pneumococcal conjugate vaccines on nasopharyngeal carriage and invasive disease among unvaccinated people: review of evidence on indirect effects.

Author: DavisStephanie M, Deloria-KnollMaria, KassaHilina T, O'BrienKatherine L

Reduced pneumococcal disease

Pneumococcal conjugate vaccines (PCVs) have a dramatic impact on rates of vaccine-type invasive pneumococcal disease (IPD) in both vaccinated and unvaccinated populations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Systematic review of the indirect effect of pneumococcal conjugate vaccine dosing schedules on pneumococcal disease and colonization.

Author: LooJennifer D, ConklinLaura, Fleming-DutraKatherine E, KnollMaria Deloria, ParkDaniel E, KirkJennifer, GoldblattDavid, O'BrienKatherine L, WhitneyCynthia G

PCV indirect benefit for older groups

This systematic review found that a 3+1 infant pneumococcal conjugate vaccine (PCV) dosing schedule has been shown to have indirect benefits for vaccine-type invasive pneumococcal disease (VT-IPD), vaccine-type nasopharyngeal carriage (VT-NP) and syndromic pneumonia, while 2+1 and 3+0 schedules have only demonstrated indirect effect for VT-IPD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Effects of Vaccination with 10-Valent Pneumococcal Non-Typeable Haemophilus influenza Protein D Conjugate Vaccine (PHiD-CV) on the Nasopharyngeal Microbiome of Kenyan Toddlers.

Author: FeazelLeah M, SantoricoStephanie A, RobertsonCharles E, BashraheilMahfudh, ScottJ Anthony G, FrankDaniel N, HammittLaura L

Pneumococcal vaccine

The nasopharyngeal microbiome (the community of microorganisms found in the nasal cavity) of children was studied to evaluate the impact of a pneumococcal vaccine on the overall bacterial diversity in the nasal cavity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

The Clinical Effectiveness of Pneumococcal Conjugate Vaccines: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Author: EwaldHannah, BrielMatthias, VuichardDanielle, KreutleVeronika, ZhydkovAndriy, GloyViktoria

Streptococcus pneumoniae is a major cause of death worldwide. This review highlights the need for updated evidence on the effects of pneumococcal conjugate vaccines on infectious diseases and mortality in various populations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Indirect effects of childhood pneumococcal conjugate vaccination on invasive pneumococcal disease: a systematic review and meta-analysis.

Author: ShiriTinevimbo, DattaSamik, MadanJason, TsertsvadzeAlexander, RoylePamela, KeelingMatt J, McCarthyNoel D, PetrouStavros

Reduced invasive pneumococcal disease

This systematic review and meta-analysis estimated the magnitude and timing of indirect effects of childhood pneumococcal conjugate vaccines (PCVs) on invasive pneumococcal disease in unvaccinated populations. The study found that population childhood PCV programmes will lead, on average, to substantial protection across the whole population within a decade.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: A systematic review and meta-analysis.

Author: BalsellsEvelyn, GuillotLaurence, NairHarish, KyawMoe H

Invasive pneumococcal disease reduction
Serotype replacement

This study examines the distribution of pneumococcal serotypes in children after the introduction of pneumococcal conjugate vaccines (PCV7/10/13) to identify leading serotypes associated with invasive pneumococcal disease (IPD). PCV7/10/13 significantly reduced IPD due to vaccine serotypes, but there has been an increase in IPD due to non-vaccine types.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Direct and Indirect Effectiveness of the 10-Valent Pneumococcal Conjugate Vaccine Against Carriage in a Cluster Randomized Trial.

Author: PalmuArto A, ToropainenMaija, KaijalainenTarja, SiiraLotta, LahdenkariMika, NieminenHeta, SyrjänenRitva K, KilpiTerhi M, JokinenJukka

Pneumococcal carriage reduction

This study investigated the direct and indirect effectiveness of a 10-valent pneumococcal conjugate vaccine (PHiD-CV10) in preventing pneumococcal carriage in children. The study found that PHiD-CV10 reduced vaccine-type carriage in both vaccinated children and their unvaccinated siblings. This is the first randomized trial to show the indirect effect of extended-valency pneumococcal conjugate vaccination on carriage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

The Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Pneumococcal Carriage in the Community Acquired Pneumonia Immunization Trial in Adults (CAPiTA) Study.

Author: van DeursenAnna M M, van HoutenMarlies A, WebberChris, PattonMichael, ScottDaniel, PattersonScott, JiangQin, GruberWilliam C, Schmoele-ThomaBeate, GrobbeeDiederick E, BontenMarc J M, SandersElisabeth A M

Pneumococcal protection

This study investigated the impact of pneumococcal conjugate vaccination on nasopharyngeal carriage in older adults. The effects of the 13-valent pneumococcal conjugate vaccine (PCV13) were examined in a randomized controlled trial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

The impact of pneumococcal conjugate vaccines on serotype 19A nasopharyngeal carriage.

Author: Tin Tin HtarMyint, SingsHeather L, SyrochkinaMaria, TaysiBulent, HiltonBetsy, SchmittHeinz-Josef, GessnerBradford D, JodarLuis

Pneumococcal carriage prevention
Protection against vaccine serotypes

This systematic review assesses the impact of pneumococcal conjugate vaccines (PCVs) containing serotype 19A or cross-reactive 19F on 19A carriage. It finds that PCV13 is more effective in reducing 19A carriage than PCV7 or PCV10, suggesting its importance in areas with high serotype 19A transmission.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Pneumococcal conjugate vaccination schedules in infants-acquisition, immunogenicity, and pneumococcal conjugate and yellow fever vaccine co-administration study.

Author: MackenzieGrant A, OseiIsaac, SalaudeenRasheed, SeckaOusman, D'AlessandroUmberto, ClarkeEd, Schmidt-ChanasitJonas, LicciardiPaul V, NguyenCattram, GreenwoodBrian, MulhollandKim

Pneumococcal disease prevention

Pneumococcal conjugate vaccines (PCVs) are effective in preventing pneumococcal disease, but their high cost limits their global impact. This study designed a large cluster-randomized field trial to evaluate the effectiveness of a reduced dose schedule of PCV compared to the standard schedule. The trial aims to assess the impact of the different schedules on immunogenicity, carriage acquisition, and co-administration with yellow fever vaccine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Constipation in Patients With Chronic Kidney Disease.

Author: ChaRa Ri, ParkSeon-Young, CamilleriMichael,

Improved bowel function
Reduced phosphate absorption
Reno-protective effects
Adverse effects
Insufficient efficacy

This review outlines the mechanisms and management of constipation in patients with chronic kidney disease (CKD). It discusses common causes, impact on overall health, and available treatment options, including lactulose, lubiprostone, linaclotide, plecanatide, tenapanor, and prucalopride.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

The Effect of Acid Suppression Therapy on the Safety and Efficacy of Plecanatide: Analysis of Randomized Phase III Trials.

Author: MoshireeBaharak, SchoenfeldPhilip, FranklinHoward, RezaieAli

Constipation treatment

This analysis investigates the efficacy and safety of plecanatide in adults with chronic idiopathic constipation (CIC) when combined with acid suppression therapy.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Diarrhea-Predominant and Constipation-Predominant Irritable Bowel Syndrome: Current Prescription Drug Treatment Options.

Author: WechslerEmily V, ShahEric D

IBS symptom relief

This review summarizes the clinical profiles of efficacy, safety, and tolerability of prescription drugs for irritable bowel syndrome (IBS), including cost-effectiveness of drugs for diarrhea-predominant IBS and constipation-predominant IBS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

Evaluating the Impact of Cost on the Treatment Algorithm for Chronic Idiopathic Constipation: Cost-Effectiveness Analysis.

Author: ShahEric D, StallerKyle, NeeJudy, AhujaNitin K, ChanWalter W, LemboAnthony, BrennerDarren M, SiegelCorey A, CheyWilliam D

Improved CIC treatment
Cost-effectiveness

Prescription drugs for chronic idiopathic constipation (CIC) increased insurer costs but decreased patient costs compared to continued over-the-counter (OTC) laxatives. From the insurer perspective, OTC laxatives were more cost-effective. From the patient perspective, plecanatide was the most cost-effective drug, followed by prucalopride and linaclotide, as these drugs had a positive impact on quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Evaluation of Plecanatide for the Treatment of Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation in Patients 65 Years or Older.

Author: MeneesStacy B, FranklinHoward, CheyWilliam D

Improved constipation symptoms

This analysis pooled data from Phase III trials in chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) to assess the safety and efficacy of plecanatide in patients aged ≥65 years.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Plecanatide Is Effective and Safe in the Treatment for Chronic Idiopathic Constipation: Results of a Phase II Trial.

Author: BarishCharles, DornSpencer, FogelRonald P, PatelReema, RosenbergJonathan

Constipation treatment
Diarrhea risk

Plecanatide, a pH-sensitive uroguanylin analog, is a new treatment option for chronic idiopathic constipation (CIC). It increases fluid and ion movement into the gastrointestinal lumen, softening stools and encouraging motility, while limiting the risk of diarrhea.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Plecanatide for the treatment of chronic idiopathic constipation in adult patients.

Author: BassottiGabrio, Usai SattaPaolo, BelliniMassimo

Bowel movement improvement
CIC severity reduction
Diarrhea
High cost

This review examines the effectiveness and safety of plecanatide, a guanylate cyclase-C agonist, in treating chronic idiopathic constipation (CIC). Clinical studies show that plecanatide is significantly more effective than placebo in reducing constipation symptoms and improving quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

Efficacy of drugs in chronic idiopathic constipation: a systematic review and network meta-analysis.

Author: LuthraPavit, CamilleriMichael, BurrNicholas E, QuigleyEamonn M M, BlackChristopher J, FordAlexander C

Constipation treatment efficacy

This network meta-analysis compared the efficacy of different drugs used to treat chronic idiopathic constipation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Benefit-Risk Assessment of Plecanatide in the Treatment of Chronic Idiopathic Constipation.

Author: MinerPhilip B

Treats chronic idiopathic constipation
Treats irritable bowel syndrome with constipation

This review assesses the efficacy and safety of plecanatide, a uroguanylin analog, for the management of chronic idiopathic constipation (CIC). Plecanatide was found to be safe and effective in treating adults with CIC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

26.

Plecanatide for Treatment of Chronic Constipation and Irritable Bowel Syndrome.

Author: LoveBryan L

Constipation treatment

Plecanatide is a new medication that stimulates a receptor in the gut to increase water secretion and soften stools. It is approved by the FDA to treat chronic idiopathic constipation and irritable bowel syndrome with constipation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

29.

Efficacy, safety, and tolerability of plecanatide in patients with irritable bowel syndrome with constipation: results of two phase 3 randomized clinical trials.

Author: BrennerDarren M, FogelRonald, DornSpencer D, KrauseRichard, EngPaul, KirshoffRobert, NguyenAnhthu, CrozierRobert A, MagnusLeslie, GriffinPatrick H

Plecanatide efficacy
Plecanatide side effects

Two phase 3, randomized, double-blind, placebo-controlled trials evaluated the efficacy and safety of plecanatide in patients with irritable bowel syndrome with constipation (IBS-C). Patients were randomized to placebo or plecanatide (3 or 6 mg). Plecanatide significantly improved both abdominal pain and constipation symptoms of IBS-C, with minimal associated side effects.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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