A Dose-Escalating Study With the Fetal Estrogen Estetrol in Healthy Men.

Author: Coelingh BenninkHerjan J T, DebruyneFrans M J, DutmanAlice E, KluftCornelis, MensingaTjeert, ReismanYacov, VerhoevenCarole, ZimmermanYvette

Paper Details 
Original Abstract of the Article :
Luteinizing hormone-releasing hormone (LHRH) agonists have replaced estrogens for endocrine treatment of advanced prostate cancer (PC) because of cardiovascular side effects. The fetal estrogen estetrol (E4) may be safer for PC treatment and is expected to decrease testosterone (T) and prevent estro...See full text at original site
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引用元:
https://doi.org/10.1210/jc.2018-00147

データ提供:米国国立医学図書館(NLM)

A Dose-Escalating Study with the Fetal Estrogen Estetrol in Healthy Men

This study delves into the field of [Endocrinology], investigating the potential of estetrol (E4), a fetal estrogen, as a treatment option for advanced prostate cancer (PC). The researchers, like intrepid explorers navigating the uncharted territory of cancer research, aimed to assess the safety and efficacy of E4 in healthy men. The study, involving a dose-escalating approach, found that E4 was well-tolerated and demonstrated a decrease in testosterone levels, suggesting its potential as an alternative to traditional estrogen therapies for PC management. The researchers emphasize the need for further studies to confirm the long-term efficacy and safety of E4 in treating PC and to establish its optimal therapeutic window.

Estetrol: A Potential New Frontier in Prostate Cancer Treatment

The study's findings, like a shimmering oasis in the arid landscape of cancer research, suggest that E4 could offer a novel and potentially safer treatment option for advanced prostate cancer. The researchers' observations of E4's ability to reduce testosterone levels, along with its favorable safety profile, open up exciting possibilities for managing PC in a less invasive and potentially more effective manner. The study's findings call for further investigation to solidify E4's role as a viable therapeutic agent for PC and to refine its application in clinical practice.

Dr.Camel's Conclusion

This study explores the potential of estetrol (E4), a fetal estrogen, as a novel treatment option for advanced prostate cancer, offering a ray of hope in the vast and often challenging landscape of cancer research. The study's findings, like a wellspring of knowledge in the desert of medical inquiry, suggest that E4 could provide a safer and potentially more effective alternative to traditional estrogen therapies. By diligently pursuing further research, we can continue to navigate the complex terrain of cancer management, seeking new and effective solutions to improve the lives of individuals battling this formidable disease.

Date :
  1. Date Completed 2019-05-28
  2. Date Revised 2019-05-28
Further Info :

Pubmed ID

29931320

DOI: Digital Object Identifier

10.1210/jc.2018-00147

SNS
PICO Info
in preparation
Languages

English

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