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Isolation, identification and in silico toxicity predictions of two isomers from cefotiam hydrochloride.

Author: HanYing, HuChang-Qin, TianYe, WangYa-Nan, ZhangXia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Two structural isomers of cefotiam were discovered in cefotiam hydrochloride for injection, and their structures were identified using various techniques. The findings may be important for quality control and stability studies of this drug class.
Paper Details　
Original Abstract of the Article :
Two structural isomers of cefotiam in cefotiam hydrochloride for injection were observed, and the structures of the isomers were determined by mass spectrometry and various 1D and 2D NMR techniques. The thermo-isomerization mechanism of cefotiam was also discussed. Thermo-isomerization occurred not ...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpba.2018.06.020

データ提供：米国国立医学図書館（NLM）

Identifying and Assessing Isomers in Cefotiam Hydrochloride

This study investigates the presence of two structural isomers in cefotiam hydrochloride for injection and determines their structures using mass spectrometry and NMR techniques. The authors also explore the thermo-isomerization mechanism and predict the potential toxicity of these isomers.

Cefotiam: Unveiling the Hidden Isomers

The study reveals the existence of two isomers in cefotiam hydrochloride, highlighting the importance of carefully considering the purity and stability of this drug. This research journey is like venturing into a hidden oasis, revealing previously unknown aspects of this widely used medication.

Ensuring Drug Safety: A Vigilant Approach

The study emphasizes the need for vigilance in drug development and quality control, reminding us that even seemingly minor variations in drug structure can have significant implications for safety and efficacy.

Dr.Camel's Conclusion

This study highlights the importance of meticulously scrutinizing drug components, including the presence of isomers, to ensure drug safety and efficacy. It underscores the need for continued research into the stability and potential toxicity of drugs to maintain patient safety.
Date :
  1. Date Completed 2018-11-08
  2. Date Revised 2018-11-08
Further Info :

Pubmed ID

29945059

DOI: Digital Object Identifier

10.1016/j.jpba.2018.06.020

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Languages

English

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