Effects of cefotaxime injection: A Synthesis of Findings from 30 Studies

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Original Abstract of the Article

Key Research Findings

This study investigated the impact of three oral cephalosporin antibiotics, cefetamet pivoxil (CET), cefixime (CFX), and cefuroxime axetil (CA), on normal human gut flora. Over a 10-day treatment period, CET had minimal impact on gut flora, while CFX and CA significantly altered gut flora, particularly increasing enterobacteria and clostridia. Notably, Salmonella spp. and Clostridium difficile emerged in 4 and 2 cases, respectively, following CFX and CA treatment.

Benefits and Risks

Benefit Summary

Cefetamet pivoxil (CET) appears to have minimal effects on gut flora compared to other oral cephalosporins.

Risk Summary

Cefixime (CFX) and cefuroxime axetil (CA) significantly impact gut flora, causing an increase in enterobacteria and clostridia, as well as the emergence of new bacteria like Salmonella spp. and Clostridium difficile.

Comparison Between Studies

Commonalities in Studies

All studies suggest that oral cephalosporin antibiotics can have an impact on gut flora.

Differences in Studies

A key difference highlighted in this study is that cefetamet pivoxil (CET) appears to have minimal effects on gut flora compared to other oral cephalosporins.

Consistency and Contradictions in Results

This study suggests that oral cephalosporin antibiotics may have varied effects on gut flora, highlighting the need for further research.

Real-Life Applications and Considerations

To minimize the impact on gut flora, it is important to consider selecting oral cephalosporins with minimal gut flora effects, such as cefetamet pivoxil (CET).

Limitations of Current Research

This study was relatively small, and further research is warranted.

Future Research Directions

Larger studies are needed to investigate the impact of oral cephalosporin antibiotics on gut flora.

Conclusion

This study demonstrates that cefetamet pivoxil (CET) appears to have minimal impact on gut flora compared to other oral cephalosporins. When considering oral cephalosporin use, careful selection of drugs is essential to minimize potential effects on gut flora.

Literature analysis of 30 papers
Positive Content
23
Neutral Content
0
Negative Content
7
Article Type
4
0
0
1
30
1.

Betalactam therapy and intestinal flora.

Author: NovelliA, MazzeiT, FallaniS, DeiR, CassettaM I, ContiS

Bronchitis treatment

Cefetamet-pivoxil (CET) had a minimal impact on normal human intestinal flora compared to cefixime (CFX) and cefuroxime axetil (CA), which significantly affected Enterobacteriaceae and clostridia. CFX and CA also led to an increase in enterococci and the appearance of Salmonella spp. and Clostridium difficile in some cases.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Plasma and peritoneal fluid concentrations of ceftriaxone after intravenous and intraperitoneal administration in horses.

Author: AlonsoJ M, PeccininiR G, CamposM L, NittaT Y, AkutagawaT Y M, CrescencioA P, AlvesA L G, RodriguesC A, WatanabeM J, HussniC A

Ceftriaxone availability
Peritonitis treatment

This study compared the effectiveness of ceftriaxone administered intravenously (IV) or intraperitoneally (IP) in horses. IP administration resulted in higher and longer-lasting ceftriaxone concentrations in peritoneal fluid, suggesting that IP delivery may be more effective for treating peritonitis in horses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Antinociceptive effects of ceftriaxone in formalin-induced nociception.

Author: Baeza-FloresGuadalupe Del Carmen, Rodríguez-PalmaErick J, Reyes-PérezValeria, Guzmán-PriegoCrystell G, Torres-LópezJorge E

Pain relief

Ceftriaxone, an antibiotic, can reduce pain in rats in a formalin-induced pain model. This suggests it may have pain-relieving properties.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Evaluating Ceftriaxone 80 mg/kg Administration by Rapid Intravenous Infusion-A Clinical Service Evaluation.

Author: PatelSanjay, GreenHelen, GrayJacqueline, RutterMichelle, BevanAmanda, HandKieran, JonesChristine E, FaustSaul N

Parent satisfaction
Patient flow

This study demonstrated that 10-minute ceftriaxone infusions for children are safe, feasible, and well-received by parents. This approach can improve efficiency in pediatric ambulatory care and community nursing services by reducing infusion times for antibiotic administration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Treatment effects of the combination of ceftriaxone and valproic acid on neuronal and behavioural functions in a rat model of epilepsy.

Author: LiHsin-Hua, LinPin-Jiun, WangWei-Han, TsengLi-Ho, TungHsin, LiuWen-Yuan, LinChih-Li, LiuChiung-Hui, LiaoWen-Chieh, HungChing-Sui, HoYing-Jui

Cognitive improvement
Neuronal density restoration
Seizure control

This study investigated whether combining valproic acid (increasing GABAergic activity) and ceftriaxone (decreasing glutamatergic activity) improves seizure control in a rat model of epilepsy. It found that the combination showed additive effects in seizure suppression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Efficacy and Safety of Single-Dose Oral Delafloxacin Compared With Intramuscular Ceftriaxone for Uncomplicated Gonorrhea Treatment: An Open-Label, Noninferiority, Phase 3, Multicenter, Randomized Study.

Author: HookEdward W, GoldenMatthew R, TaylorStephanie N, HenryEugenia, TsengCarol, WorkowskiKimberly A, SwerdlowJerri, NenningerAshley, CammarataSue

Gonorrhea treatment

This study evaluated the efficacy and safety of delafloxacin, a new fluoroquinolone antibiotic, compared to ceftriaxone for the treatment of uncomplicated urogenital gonorrhea. The study found that both delafloxacin and ceftriaxone were effective in treating uncomplicated urogenital gonorrhea.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Ceftriaxone modulates the acute corticosterone effects in local field potentials in the primary somatosensory cortex of anesthetized mice.

Author: Pais-VieiraMiguel, KunickiCarolina, PeresAndré, SousaNuno

Reduced glutamate toxicity

Ceftriaxone may help counteract the effects of corticosterone on brain activity. This study found that ceftriaxone and corticosterone have opposite effects on specific frequency bands in the somatosensory cortex of mice, suggesting ceftriaxone could potentially reverse the negative effects of stress hormone on brain function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

A 4-month-old baby presenting with dermal necrotizing granulomatous giant cell reaction at the injection site of 13-valent pneumococcal conjugate vaccine: a case report.

Author: AlsuwaidiAhmed R, AlbawardiAlia, KhanNavidul Haq, SouidAbdul-Kader

Inflammation

A severe inflammatory reaction occurred at the injection site of a pneumococcal conjugate vaccine, highlighting the potential for severe local adverse events associated with certain vaccines, especially if not administered deeply into the muscle.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Effectiveness of audit and feedback in addressing over prescribing of antibiotics and injectable medicines in a middle-income country: an RCT.

Author: SoleymaniFatemeh, RashidianArash, HosseiniMostafa, DinarvandRassoul, KebriaeezadeAbbas, AbdollahiMohammad

Improved prescribing practices
Overprescribing

This study evaluated three interventions to reduce antibiotic and injectable medicine overprescribing in Iran. A new-design audit and feedback intervention significantly reduced prescriptions of dexamethasone and cefixime. Printed educational material also reduced cefixime prescriptions. While these interventions were effective, the improvements were modest, suggesting more intensive interventions are needed to tackle overprescribing issues.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Recurrent bacteremia after injection of N-butyl-2-cyanoacrylate for treatment of bleeding gastric varices: a case report and review of the literature.

Author: RandiBruno A, NinomiyaDaniel A, NicodemoElizabeth L, LopesBeatriz C, CançadoEduardo R, LevinAnna S

Variceal obliteration
Recurrent bacteremia

Recurrent bacteremia is a rare but possible complication after gastric varices treatment with N-butyl-2-cyanoacrylate.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Prevalence of gonococcal conjunctivitis in adults and neonates.

Author: McAnenaL, KnowlesS J, CurryA, CassidyL

Gonococcal conjunctivitis

This study investigates the prevalence and characteristics of gonococcal conjunctivitis in pregnant women and patients at an ophthalmic hospital.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Controlled release of ciprofloxacin and ceftriaxone from a single ototopical administration of antibiotic-loaded polymer microspheres and thermoresponsive gel.

Author: BrukLiza A, DunkelbergerKatherine E, KhampangPawjai, HongWenzhou, SadagopanSrivatsun, AlperCuneyt M, FedorchakMorgan V

Reduced antibiotic dose
Reduced systemic effects
Sustained drug delivery
Biofilm formation
Spontaneous bacterial clearance

A novel topical, thermoresponsive gel depot with antibiotic-loaded microspheres was developed for delivering antibiotics to the middle ear. In vitro and ex vivo studies showed the gel could deliver therapeutic drug concentrations for up to 14 days. Animal studies suggest the system can safely treat bacterial infection, although spontaneous clearance was observed in some cases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

The ameliorative effects of ceftriaxone and vitamin E against cisplatin-induced nephrotoxicity.

Author: Abdel-DaimMohamed M, AleyaLotfi, El-BialyBadr E, AbushoukAbdelrahman Ibrahim, AlkahtaniSaad, AlarifiSaud, AlkahtaneAbdullah A, AlBasherGadah, AliDaoud, AlmeerRafa S, Al-SultanNouf K, AlghamdiJawahir, AlahmariAbeer, BungauSimona G

Antioxidant effects
Nephroprotection
Cisplatin nephrotoxicity

Cisplatin (CDDP) can cause kidney damage (nephrotoxicity). This study found that ceftriaxone (CTX) and vitamin E (Vit.E), especially when combined, can reduce CDDP-induced kidney injury. This protection is likely due to their antioxidant and anti-inflammatory effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

[NET WATER TRANSPORT VIA RAT COLON EPITELIUM UNDER THE EXPERIMENTAL DYSBIOSIS].

Author: DovbynchukT, ZakordonetsL, PutnikovA, VareniukI, TiapkoO, RoslovaN, SergiychukT, LynchakO, DzerzhynskyM, BeregovaT, TolstanovaG

Increased water absorption
Mast cell degranulation
Pro-inflammatory changes

This study showed that azithromycin increased water absorption in rat colons, while ceftriaxone decreased it. Azithromycin upregulated AQP8, while ceftriaxone caused inflammation.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Ukrainian

20.

Single-Dose Zoliflodacin (ETX0914) for Treatment of Urogenital Gonorrhea.

Author: TaylorStephanie N, MarrazzoJeanne, BatteigerByron E, HookEdward W, SeñaArlene C, LongJill, WierzbickiMichael R, KwakHannah, JohnsonShacondra M, LawrenceKenneth, MuellerJohn

Effective for gonorrhea
Well tolerated
Gastrointestinal effects
Less effective for pharyngeal infections

This multicenter, phase 2 trial evaluated zoliflodacin for the treatment of uncomplicated gonorrhea. The majority of uncomplicated urogenital and rectal gonococcal infections were successfully treated with oral zoliflodacin, but this agent was less efficacious in the treatment of pharyngeal infections.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

21.

Fecal short-chain fatty acids at different time points after ceftriaxone administration in rats.

Author: HolotaYu V, HolubenkoO O, OstapchukA M, SerhiychukT M, ZakordonetsL V, TolstanovaG M

Microbiota disturbance

Antibiotic treatment (ceftriaxone) led to long-term changes in the production of short-chain fatty acids (SCFAs) in the colon of rats, indicating a disruption of the gut microbiome's metabolic activity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Synthetic cathinone MDPV downregulates glutamate transporter subtype I (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator.

Author: GreggRyan A, HicksCallum, NayakSunil U, TallaridaChristopher S, NuceroPaul, SmithGarry R, ReitzAllen B, RawlsScott M

MDPV-induced sensitization
Synthetic cathinone abuse

Synthetic cathinone use can disrupt glutamate transport in the brain, specifically decreasing GLT-1 expression. A GLT-1 activator was able to reduce the rewarding and stimulant effects of MDPV, a synthetic cathinone, in rats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

23.

Carbohydrate composition of rat intestine surface mucus layer after ceftriaxone treatment.

Author: HolotaYu V, OlefirYa A, DovbynchukT V, TolstanovaG M

Inflammatory bowel disease

Antibiotic treatment (ceftriaxone) caused long-term changes in the composition of the colon's mucus layer in rats, potentially contributing to increased susceptibility to inflammatory bowel disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Antiallodynic Activity of Ceftriaxone and Clavulanic Acid in Acute Administration is Associated with Serum TNF-α Modulation and Activation of Dopaminergic and Opioidergic Systems.

Author: Ochoa-AguilarA, Sotomayor-SobrinoM A, JaimezR, RodríguezR, Plancarte-SánchezR, Ventura-MartinezR

Antiallodynic effect
NP treatment

This study investigated the effectiveness of ceftriaxone and clavulanic acid in treating neuropathic pain (NP) in rats. Both drugs were found to reduce pain sensations, similar to gabapentin, a standard treatment. The pain-relieving effects were linked to dopamine and opioid pathways and a reduction in TNF-α levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Ceftriaxone reduces alcohol intake in outbred rats while upregulating xCT in the nucleus accumbens core.

Author: StennettBethany A, FrankowskiJan C, PerisJoanna, KnackstedtLori A

Reduced alcohol consumption

Ceftriaxone decreased alcohol consumption in rats and increased xCT expression in the nucleus accumbens. This suggests a potential role for ceftriaxone in treating alcohol addiction by modulating glutamate transmission.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

27.

The effects of ceftriaxone by intravenous push on adverse drug reactions in the emergency department.

Author: AgunbiadeAbdulkareem, RoutsoliasJoanne C, RizvanolliLum, BleifussWill, SundaresanSharadram, MoskoffJordan

ED efficiency
IVP safety
Ceftriaxone adverse reactions

Intravenous push (IVP) administration of ceftriaxone was associated with a lower rate of adverse reactions than previously reported, suggesting potential benefits for ED efficiency and cost savings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

28.

Imaging in vivo glutamate fluctuations with [(11)C]ABP688: a GLT-1 challenge with ceftriaxone.

Author: ZimmerEduardo R, ParentMaxime J, LeuzyAntoine, AliagaAntonio, AliagaArturo, MoquinLuc, SchirrmacherEsther S, SoucyJean-Paul, SkelinIvan, GrattonAlain, GauthierSerge, Rosa-NetoPedro

Neuropsychiatric research

mGluR5 allosteric binding sites are sensitive to glutamate levels in the brain. This could be used to study neuropsychiatric conditions involving glutamate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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