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Effects of amiloride on physiological activity of stem cells of human lung cancer and possible mechanism.

Author: HuChenchen, HuangHe, LaiYongxin, LiFei, PengCaixia, WangDegui, ZhangHengshuo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of amiloride on lung cancer stem cells (CSCs). The researchers found that amiloride inhibited CSC proliferation, migration, and invasion while promoting apoptosis.
Paper Details　
Original Abstract of the Article :
Lung cancer is a common malignant tumor, the cancer stem cells (CSCs) were regarded responsible for the development of cancer tissue. The effects of amiloride on lung cancer stem cells and the possible mechanism were not much investigated. In this study, human NCI-H1975 lung CSCs were selected by fl...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbrc.2018.06.138

データ提供：米国国立医学図書館（NLM）

Amiloride: A Potential Weapon Against Lung Cancer Stem Cells

Lung cancer, a leading cause of cancer-related deaths, presents a formidable challenge in healthcare. This research, a journey through the desert of cancer research, investigates the potential of amiloride, a diuretic drug, in targeting lung cancer stem cells (CSCs).

Targeting the Roots: Targeting Cancer Stem Cells

CSCs, a small population of cells within a tumor, are thought to be responsible for tumor growth, metastasis, and resistance to therapy. This research, like a precise strike at the heart of a desert oasis, focuses on inhibiting the activity of CSCs in lung cancer.

The Results: A Promising Anti-Cancer Effect

The study revealed that amiloride effectively inhibited the proliferation, migration, and invasion of lung CSCs while promoting apoptosis (programmed cell death). These findings suggest that amiloride may have significant potential as an anti-cancer agent, specifically targeting CSCs.

Health Implications and Everyday Life: A New Hope in the Desert of Lung Cancer

This research, a beacon of hope in the desert of lung cancer research, highlights the potential of amiloride in targeting lung CSCs. For individuals battling lung cancer, this research provides a glimmer of optimism for new treatment strategies that could effectively target the roots of the disease.

Dr. Camel's Conclusion

This research, a compelling exploration in the desert of cancer research, showcases the potential of amiloride in targeting lung CSCs. The findings suggest that amiloride may offer a novel therapeutic approach to lung cancer, potentially improving treatment outcomes and extending patient survival.

Date :
  1. Date Completed 2019-03-04
  2. Date Revised 2019-03-04
Further Info :

Pubmed ID

29958884

DOI: Digital Object Identifier

10.1016/j.bbrc.2018.06.138

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Article Analysis
・Effects of amiloride
SNS
PICO Info
in preparation
Languages

English

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