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Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis.

Author: , AcharJay, AmanullahFarhana, BarryPennan, BecerraMercedes, ChanEdward D, ChanPei Chun, CrossaAldo, DrobacPeter C, FairlieLee, FalzonDennis, FloodJennifer, FurinJennifer, Garcia-PratsAnthony J, GegiaMedea, HarauszElizabeth P, HesselingAnneke C, HicksRobert M, Ioana ChiotanDomnica, IsaakidisPetros, KadriS M, KampmannBeate, KredoTamara, LawStephanie, MadhiShabir A, MaraisElse, MariandyshevAndrei, MenziesDick, MooreBrittany Kathryn, Méndez-EchevarríaAna, NargizaParpieva, OzereIveta, PadayatchiNesri, RybakNatasha, Santiago-GarciaBegoña, SchaafH Simon, SeddonJames A, ShahN Sarita, SharmaSangeeta, ShimTae Sun, SkrahinaAlena, Soriano-ArandesAntoni, TurkovaAnna, Ur-RehmanSaleem-, WilliamsBhanu, YablokovaElena, YimJae-Joon, van den BoomMartin, van der WerfMarieke J, van der WerfTjip S

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Children with multidrug-resistant tuberculosis (MDR-TB) responded favorably to treatment, but those infected with HIV who did not receive antiretroviral treatment (ART) had a low success rate.
Paper Details　
Original Abstract of the Article :
BACKGROUND: An estimated 32,000 children develop multidrug-resistant tuberculosis (MDR-TB; Mycobacterium tuberculosis resistant to isoniazid and rifampin) each year. Little is known about the optimal treatment for these children. METHODS AND FINDINGS: To inform the pediatric aspects of the revised ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040687/

データ提供：米国国立医学図書館（NLM）

MDR-TB in Children: A Challenging Desert Journey

Multidrug-resistant tuberculosis (MDR-TB) is a serious threat to global health, particularly among children. Treating MDR-TB in children is a complex and challenging journey, often requiring long treatment regimens and managing potential side effects. This study delves into the treatment of MDR-TB in children, seeking to understand the complexities of this challenging condition and find paths to successful treatment.

The authors conducted a comprehensive systematic review and individual patient data meta-analysis, analyzing data from 975 children with MDR-TB. The study found that children with confirmed MDR-TB were more likely to be older, infected with HIV, malnourished, and to have severe tuberculosis on chest radiograph. The study also found that treatment success was associated with the use of second-line injectable agents and high-dose isoniazid. The study highlights the importance of early diagnosis, appropriate treatment regimens, and the need for effective HIV management in children with MDR-TB.

A Beacon of Hope in the Desert of MDR-TB

Despite the challenges, the study offers a ray of hope, highlighting the high treatment success rate for children with MDR-TB. The study's findings emphasize the importance of ongoing research to refine treatment strategies and improve outcomes for children with this challenging condition.

Navigating the Desert of MDR-TB

This research underscores the importance of a multi-faceted approach to managing MDR-TB in children, including early diagnosis, appropriate treatment, and effective HIV management. It is a reminder that the journey through the desert of MDR-TB is long and challenging, but with persistent research and dedication, we can find pathways to successful treatment and improved health outcomes for children with this complex condition.

Dr.Camel's Conclusion

The treatment of multidrug-resistant tuberculosis in children is a challenging journey through a vast and unforgiving desert. This study underscores the need for a multi-faceted approach, including early diagnosis, effective treatment regimens, and comprehensive HIV management. The research offers a glimmer of hope, suggesting that with continued research and innovation, we can find pathways to successful treatment and improved health outcomes for children with this challenging condition.

Date :
  1. Date Completed 2019-04-09
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

29995958

DOI: Digital Object Identifier

PMC6040687

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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