Treatments for Crohn's Disease-Associated Bowel Damage: A Systematic Review.

Author: BettenworthDominik, DaneseSilvio, DesreumauxPierre, HuShurong, LouisEdouard, MeuwisMarie-Alice, ParienteBenjamin, RiederFlorian, SpecaSilvia

Paper Details 
Original Abstract of the Article :
BACKGROUND & AIMS: Despite significant advances in the treatment of Crohn's disease (CD), most patients still develop stricturing or penetrating complications that require surgical resections. We performed a systematic review of mechanisms and potential treatments for tissue damage lesions in CD pat...See full text at original site
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引用元:
https://doi.org/10.1016/j.cgh.2018.06.043

データ提供:米国国立医学図書館(NLM)

Crohn's Disease: A Journey Through the Digestive Desert

The [management of Crohn's disease (CD)] is a complex and challenging journey through the often unpredictable landscape of the digestive system. This study delves into the complexities of [intestinal damage] in CD patients, exploring the underlying mechanisms and investigating potential treatment strategies. The researchers conducted a [systematic review] of published literature to synthesize existing knowledge and identify promising avenues for future research.

Exploring the Mechanisms of Intestinal Damage in Crohn's Disease

The study highlights the intricate interplay of cellular processes that contribute to [intestinal damage] in CD patients. This includes [fibroblast proliferation and migration, activation of stellate cells, and altered balance of metalloproteinases and tissue inhibitors of metalloproteinases]. Understanding these mechanisms is crucial for developing effective treatment strategies that can target the root causes of intestinal damage.

Hope on the Horizon: New Treatments for Crohn's Disease

The study offers hope for [CD patients] by exploring promising treatment approaches, such as [therapies that reduce excessive transforming growth factor beta (TGFB) activation and stem cell therapies]. These innovative strategies hold potential for healing established intestinal damage and improving the quality of life for those living with CD.

Dr.Camel's Conclusion

As a researcher who has trekked through the vast and complex desert of medical knowledge, I am inspired by the ongoing quest to find solutions for [Crohn's disease]. This study reminds us that even in the face of complex and challenging conditions, there is always hope for progress and innovation. By unraveling the mysteries of intestinal damage and pursuing new treatment strategies, we can help individuals navigate the challenging terrain of CD with greater strength and resilience.
Date :
  1. Date Completed 2020-07-29
  2. Date Revised 2020-07-29
Further Info :

Pubmed ID

30012430

DOI: Digital Object Identifier

10.1016/j.cgh.2018.06.043

SNS
PICO Info
in preparation
Languages

English

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