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Risk of recurrence after treatment of first-episode genital herpes with intravenous acyclovir.

Author: AdlerM W, BenedettiJ, CoreyL, FifeK H, MindelA, SutherlandS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the effectiveness of intravenous acyclovir in preventing or reducing future outbreaks of genital herpes in 61 patients experiencing their first outbreak. While there was no significant difference in the time to the first outbreak or the frequency of outbreaks between those treated with acyclovir and those who received placebo, the study found that the type of herpes virus was the most significant factor in determining the frequency of future outbreaks. Patients with herpes simplex virus type 1 (HSV-1) had fewer outbreaks and a longer time to the first recurrence compared to those with HSV-2. The study concludes that intravenous acyclovir has little effect on future outbreaks of genital herpes.
Paper Details　
Original Abstract of the Article :
To determine whether intravenous acyclovir treatment for a first episode of genital herpes could prevent or reduce subsequent recurrences, we combined and analyzed the results of two independently conducted, randomized, double-blind, placebo-controlled studies. Sixty-one patients were enrolled in th...See full text at original site
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引用元：
https://doi.org/10.1097/00007435-198510000-00009

データ提供：米国国立医学図書館（NLM）

The Intricate Dance of Herpes Simplex Virus: A Tale of Two Types

The world of [viral infections] is a fascinating one, filled with complex interactions between pathogens and their hosts. This study delves into the realm of [genital herpes], specifically investigating the impact of [intravenous acyclovir treatment] on subsequent recurrences. The researchers employed a [randomized, double-blind, placebo-controlled study] design, meticulously comparing the outcomes of [acyclovir] and [placebo] treatment groups. Their findings suggest that the [type of herpes simplex virus (HSV)] plays a crucial role in determining the likelihood of recurrences, with [HSV-1] infections exhibiting a significantly longer median time to the first recurrence and lower frequency of recurrences compared to [HSV-2] infections. Intriguingly, the study discovered that [acyclovir treatment] had little impact on the recurrence rates, highlighting the importance of understanding the viral subtype for effective management strategies.

Understanding the Viral Landscape: A Key to Herpes Management

The study's findings highlight the critical role of the [HSV type] in influencing the course of [genital herpes]. The significant differences observed between [HSV-1] and [HSV-2] suggest that [viral subtype] should be a primary consideration in developing personalized treatment plans. It's like navigating a desert - understanding the unique terrain is crucial for finding the right path. In the case of [genital herpes], understanding the specific viral subtype is key to navigating a successful treatment course.

Living with Herpes: Insights for a Healthier Life

This research underscores the importance of [understanding viral subtypes] for effective [herpes management]. While the study suggests that [acyclovir treatment] may not significantly alter recurrence rates, it emphasizes the role of [early diagnosis and appropriate treatment] in managing this condition. Remember, just as a well-prepared traveler can navigate a desert with ease, a well-informed individual can manage [herpes] effectively.

Dr.Camel's Conclusion

This research sheds light on the importance of understanding the specific [HSV type] in determining [genital herpes] recurrence rates. While [acyclovir treatment] may not be a game-changer in preventing recurrences, it emphasizes the need for personalized treatment approaches based on [viral subtype]. It's like navigating a vast, ever-shifting desert - understanding the unique challenges of the terrain is key to reaching your destination.

Date :
  1. Date Completed 1986-02-07
  2. Date Revised 2019-09-08
Further Info :

Pubmed ID

3001952

DOI: Digital Object Identifier

10.1097/00007435-198510000-00009

Related Literature

Article Analysis
・Effective treatment of genital herpes
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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