Effective treatment of genital herpes: A Synthesis of Findings from 67 Studies

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Original Abstract of the Article

Major Research Findings

Multiple studies have shown that antiviral medications are effective in treating genital herpes. 61 , 28 , 34 , 40 , 9 , 36 , 20 , 30 , 53 , 57 , 24 , 44 , 14 , 59 , 38 , 63 , 12 , 50 , 23 , 33 , 32 , 6 , 43 , 65 , 19 , 25 , 2 , 22 , 15 , 55 , 18 , 47 , 51 , 62 , 46 , 58 , 45 , 29 , 5 , 35 .

For example, acyclovir has been shown to shorten the duration of viral shedding and the duration of symptoms in patients with genital herpes. 34 , 36 . Famciclovir has been found to be as effective as a 3-day valacyclovir regimen when administered twice daily in a single-day therapy. 59 .

Treatment Summary

Research findings show that antiviral medications such as acyclovir, valacyclovir, and famciclovir are effective in treating genital herpes. 34 , 36 , 59 . These medications help reduce the duration of viral shedding, the duration of symptoms, and can help suppress outbreaks. 34 , 36 , 59 .

Benefits and Risks

Benefits Summary

Antiviral medications have been shown to reduce the severity of symptoms associated with genital herpes and shorten the duration of viral shedding. 34 , 36 . They also have the potential to suppress outbreaks. 59 .

Risks Summary

While generally safe, antiviral medications can have side effects including gastrointestinal symptoms like nausea, vomiting, and diarrhea, as well as dizziness and headaches. 36 . There is also the concern of developing resistance to the medication with long-term use. 61 .

Comparison Across Studies

Similarities Across Studies

Many studies have shown that antiviral medications are effective in treating genital herpes. 34 , 36 , 59 . These medications have been generally found to be safe. 36 .

Differences Across Studies

Due to variations in the medications used, dosage methods, and evaluation criteria across studies, comparing results should be done cautiously. For example, the duration of acyclovir treatment varies between studies, ranging from 5 days to 6 months. 34 , 18 .

Consistency and Contradictions in Results

While many studies show that antiviral medications are effective in treating genital herpes, there is variability in the extent of the effect, duration, and side effects across studies. 34 , 36 , 59 . Some studies have found that antiviral medications shorten the duration of viral shedding but do not prevent reoccurrence. 34 .

Considerations for Applying Research to Everyday Life

Genital herpes is a recurrent condition that often requires long-term use of antiviral medications. 61 . As antiviral medications can have side effects, it is vital to take them according to a doctor's instructions. 36 . Even when symptoms improve, it is important to understand that the condition isn't cured. Maintaining a healthy lifestyle, practicing safe sex, and using condoms during sexual activity can help prevent reoccurrence. 61 .

Current Research Limitations

Current research lacks a complete understanding of the long-term effects of antiviral medications, including their long-term efficacy, side effects, and the development of resistance. 61 . Also, many studies primarily include Caucasian participants, and further research is needed to examine racial differences in effectiveness and side effects. 62 .

Future Research Directions

Research is needed to investigate the long-term effects of antiviral medications, including their long-term effectiveness, side effects, and the development of resistance. 61 . Studies are also needed to explore the potential differences in effectiveness and side effects based on race, age, and sex. 62 .

Conclusion

Multiple studies have shown that antiviral medications are effective in treating genital herpes. 34 , 36 , 59 . However, these medications do not completely prevent reoccurrence. 61 . Genital herpes is a recurrent condition, so receiving appropriate treatment under the guidance of a doctor is crucial. 61 .

Treatment List

Acyclovir, valacyclovir, famciclovir, interferon alpha 2 , heparin 22 , co-trimoxazole 20 , inosine pranobex 6 , foscarnet 12 , valaciclovir 47 , Virend 46 and others.

Keywords
Benefit Keywords
Genital herpes treatment
1
Topical interferon
Viral shedding
2
Herpes recurrence reduction
3
Reduced signs of herpes
Reduced viral shedding
Well-tolerated
4
Reduced symptom duration
Reduced virus shedding
5
Genital herpes treatment
6
Reduced herpes recurrence
7
Genital herpes treatment
8
Reduced herpes symptoms
9
Prevented recurrences
Safe treatment
10
Reduced recurrence frequency
11
Higher proportion of symptom-free individuals
Reduced viral shedding
12
Genital herpes treatment
14
Genital herpes treatment
15
Reduced healing time
Reduced viral shedding
16
Suppressed genital herpes
17
Genital herpes treatment
18
Reduced recurrence frequency
19
Improved healing time
Reduced pain
Reduced viral shedding
20
Reduced itching
21
Improved genital herpes treatment
22
Genital herpes treatment
23
Reduced healing time
Reduced symptom duration
24
Recurrent herpes prevented
Safe treatment
25
Herpes treatment
26
Accelerated healing
Reduced duration of viral shedding
Reduced symptom duration
27
Reduced symptoms
Reduced viral shedding
Well tolerated
28
Effective treatment
Reduced recurrence rate
29
Improved healing time
Reduced complications
Reduced symptom duration
Reduced viral shedding
30
Genital herpes suppression
31
Genital herpes reduction
32
Improved healing time
Reduced symptom duration
Reduced viral shedding
33
Genital herpes treatment
34
Improved healing time
Reduced symptom duration
Reduced viral shedding
35
Improved healing time
Reduced symptom duration
Reduced viral shedding
36
Improved healing time
Reduced symptom duration
Reduced viral shedding
37
Genital herpes treatment
38
Improved healing time
Prevented new lesion formation
Reduced symptom duration
39
Improved healing time
Reduced symptom duration
40
Faster healing
Fewer side effects
Shorter duration of viral shedding
41
Minor severity of lesions
Reduced frequency of recurrences
Shorter duration of lesions
42
Fewer recurrences
43
Improved understanding of genital herpes
44
Convenient dosing
Effective treatment
45
Genital herpes treatment
46
Valacyclovir effective
Valacyclovir well tolerated
47
Improved herpes zoster and genital herpes treatment
48
Faster crusting
Improved herpes symptoms
49
Dosing comfort
Herpes treatment
50
Increased proportion of aborted episodes
Reduced duration of episode
Reduced duration of lesions
51
Aborts HSV lesions
Prevents HSV lesions
52
Genital herpes treatment
Well tolerated
53
Herpes treatment
54
Improved genital herpes treatment
55
Improved quality of life
Reduced outbreaks
56
Genital herpes recurrence prevention
57
Extended time to outbreaks
58
Herpes treatment
59
Effective treatment for herpes
Improved patient compliance
Shorter treatment duration
60
Effective herpes treatment
61
RGH treatment
62
Increased effectiveness
Reduced recurrence rate
63
Reduced symptom duration
65
Genital herpes treatment
Oral herpes treatment
66
Management of genital herpes infection
67
Risk Keywords
Relapses
1
Side effects
9
Not effective for established lesions
12
Relapses
17
Treatment withdrawal
25
Drug resistance
Hypersensitivity
31
Mild adverse events
45
Mild adverse effects
49
Adverse effects
50
Genital herpes
55
Antiviral resistance
61
Adverse events
65
Literature analysis of 67 papers
Positive Content
64
Neutral Content
3
Negative Content
0
Article Type
63
2
3
7
67
1.

Genital herpes: Treatment with methylene blue and light exposure.

Author: ChangT W, FiumaraN, WeinsteinL

Genital herpes treatment
Relapses

Photodynamic inactivation of herpesvirus using methylene blue, proflavine, or neutral red temporarily eradicated the disease in 70% of patients with genital herpes. However, relapses were not prevented or reduced.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Recombinant alpha-2 interferon gel treatment of recurrent herpes genitalis.

Author: LebwohlM, SacksS, ConantM, ConnorJ, DouglasJ M, EronL, MarloweS, MendelsonJ, ChenV, BradstreetP

Topical interferon
Viral shedding

A study of 387 patients with recurrent genital herpes found that topical interferon treatment reduced the duration of viral shedding by 26%. For men, interferon also significantly reduced the time it took for sores to crust over (17%), as well as pain (34%) and itching (21%). The study concluded that topical interferon is an effective treatment for recurrent genital herpes, particularly for men, by shortening the duration of viral shedding and alleviating symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

[Prolonged treatment with acyclovir in recurrent genital herpes. Clinical, virological, and immunological response].

Author: VelascoM, SaavedraT, SepúlvedaC, SuárezM

Herpes recurrence reduction

A study of 55 patients with recurrent genital herpes compared the effectiveness of a 6-month course of oral acyclovir to a placebo. Patients receiving acyclovir experienced a significant reduction in herpes outbreaks compared to the placebo group, who showed no change in recurrence frequency. Acyclovir was well-tolerated with minimal side effects. Immunological testing revealed no significant changes in either group. This study suggests that prolonged oral acyclovir treatment can effectively reduce the frequency of genital herpes outbreaks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Spanish

4.

Randomized, double-blind, placebo-controlled, clinic-initiated, Canadian multicenter trial of topical edoxudine 3.0% cream in the treatment of recurrent genital herpes. Canadian Cooperative Study Group.

Author: SacksS L, TyrrellL D, LaweeD, SchlechW, GillM J, AokiF Y, MartelA Y, SingerJ

Reduced signs of herpes
Reduced viral shedding
Well-tolerated

A study of 200 patients with recurrent genital herpes found that edoxudine 3% cream was effective in reducing viral shedding and time to healing, particularly for women. Edoxudine was well-tolerated but its long-term role in managing recurrent genital herpes requires further evaluation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Randomized, double-blind, placebo-controlled, patient-initiated study of topical high- and low-dose interferon-alpha with nonoxynol-9 in the treatment of recurrent genital herpes.

Author: SacksS L, VarnerT L, DaviesK S, RekartM L, StiverH G, DeLongE R, SellersP W

Reduced symptom duration
Reduced virus shedding

This study compared the effectiveness of high-dose and low-dose topical interferon-alpha to placebo for treating recurrent genital herpes in 188 patients. High-dose interferon significantly reduced the time to negative viral cultures (2.5 vs 3.9 days) and shortened the duration of symptoms (2.7 vs. 3.7 days), particularly for women. These benefits were more prominent when treatment was started early in the outbreak, during the prodrome or early symptom stage. The study suggests that high-dose topical interferon-alpha is a safe and effective treatment option for recurrent genital herpes, particularly when applied early in the outbreak.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Treatment of first-attack genital herpes--acyclovir versus inosine pranobex.

Author: MindelA, KinghornG, Allason-JonesE, WoolleyP, BartonI, FahertyA, JeavonsM, WilliamsP, PatouG

Genital herpes treatment

A study of 77 patients with first-time genital herpes found that acyclovir was more effective than inosine pranobex in reducing symptoms and viral shedding.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Suppression of frequently recurring genital herpes: acyclovir v inosine pranobex.

Author: MindelA, CarneyO, SonnexC, FrerisM, PatouG, WilliamsP

Reduced herpes recurrence

This study compared the effectiveness of acyclovir and inosine pranobex in suppressing recurrent genital herpes in 31 patients. Acyclovir significantly reduced the frequency and delayed the time of recurrence compared to inosine pranobex. Both treatments were well-tolerated. The study concludes that acyclovir is the preferred treatment for suppressing frequent genital herpes outbreaks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Oral acyclovir suppression of recurrent genital herpes: a double-blind, placebo-controlled, crossover study.

Author: HalsosA M, SaloO P, LassusA, TjøttaE A, HoviT, GabrielsenB O, FiddianA P

Genital herpes treatment

This study of 31 men with recurrent genital herpes found that acyclovir (200 mg four times a day) significantly reduced the frequency and duration of outbreaks compared to placebo. Acyclovir completely prevented outbreaks in 77% of patients. Side effects were similar for both treatments. While long-term effects on recurrence rates were not observed, the study suggests that long-term acyclovir treatment may be a viable option for controlling severe forms of genital herpes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

[Acyclovir creme in recurrent herpes genitalis].

Author: LaerumE, GabrielsenB O, HalsosA, JohnsonM, MosengD, HellandS, SlørdahlM

Reduced herpes symptoms
Side effects

This study compared acyclovir cream to a placebo cream for treating recurrent genital herpes in 96 patients. Acyclovir cream significantly reduced the severity and duration of herpes outbreaks, with 59.4% of patients experiencing a benefit compared to 34.4% on placebo. The benefit was even greater when treatment started within four hours of symptom onset. Pain and burning lasted less than four days in 70.8% of patients using acyclovir cream compared to 36.4% using placebo cream. Overall healing time was also significantly shorter with acyclovir. Side effects were similar in both groups, with mild to moderate reactions occurring in 13.5% of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Norwegian

10.

Oral acyclovir suppressive therapy in severe recurrent genital herpes. A double-blind, placebo-controlled cross-over study.

Author: KroonS, PetersenC S, AndersenL P, RasmussenL P, VestergaardB F

Prevented recurrences
Safe treatment

A study of 24 patients with recurrent genital herpes found that acyclovir (400 mg twice daily for 12 weeks) was effective in preventing recurrences, with 71% of patients experiencing no recurrences during treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Dosage and safety of long-term suppressive acyclovir therapy for recurrent genital herpes.

Author: MindelA, FahertyA, CarneyO, PatouG, FrerisM, WilliamsP

Reduced recurrence frequency

A study of 131 patients with recurrent genital herpes found that long-term suppression with acyclovir was safe and effective in reducing the frequency of recurrences.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Clinical course of recurrent genital herpes and treatment with foscarnet cream: results of a Canadian multicenter trial.

Author: SacksS L, PortnoyJ, LaweeD, SchlechW, AokiF Y, TyrrellD L, PoissonM, BrightC, KaluskiJ

Higher proportion of symptom-free individuals
Reduced viral shedding
Not effective for established lesions

This study compared foscarnet cream to placebo in treating 309 patients with recurrent genital herpes. The study found that foscarnet did not significantly reduce the time to healing or symptom relief overall, but more patients were symptom-free after one day of treatment with foscarnet. Foscarnet also significantly reduced the duration of virus shedding in men. However, the study concludes that these benefits are not enough to justify widespread use of foscarnet for established herpes outbreaks. Earlier treatment, during the prodromal phase, might be more effective, but studies of patient-initiated treatment are difficult to interpret due to a higher proportion of culture-negative episodes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Risk of recurrence after treatment of first-episode genital herpes with intravenous acyclovir.

Author: CoreyL, MindelA, FifeK H, SutherlandS, BenedettiJ, AdlerM W

This study investigated the effectiveness of intravenous acyclovir in preventing or reducing future outbreaks of genital herpes in 61 patients experiencing their first outbreak. While there was no significant difference in the time to the first outbreak or the frequency of outbreaks between those treated with acyclovir and those who received placebo, the study found that the type of herpes virus was the most significant factor in determining the frequency of future outbreaks. Patients with herpes simplex virus type 1 (HSV-1) had fewer outbreaks and a longer time to the first recurrence compared to those with HSV-2. The study concludes that intravenous acyclovir has little effect on future outbreaks of genital herpes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Double-blind, placebo-controlled trial comparing long-term suppressive with short-term oral acyclovir therapy for management of recurrent genital herpes.

Author: MattisonH R, ReichmanR C, BenedettiJ, BolgianoD, DavisL G, Bailey-FarchioneA, RemingtonM, WinterC, CoreyL

Genital herpes treatment

This study compared the effectiveness of three treatments for 156 patients with frequent genital herpes outbreaks: daily acyclovir, intermittent acyclovir, and placebo. The study found that daily acyclovir was significantly more effective than both intermittent acyclovir and placebo in reducing the frequency and duration of outbreaks. The average number of days per month with outbreaks was 0.32 for the daily acyclovir group, compared to 4.18 for the intermittent group and 4.72 for the placebo group. The study concludes that daily acyclovir is the most effective treatment for patients with frequent genital herpes outbreaks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Intravenous acyclovir therapy of first episodes of genital herpes: a multicenter double-blind, placebo-controlled trial.

Author: PeacockJ E, KaplowitzL G, SparlingP F, DurackD T, GnannJ W, WhitleyR J, LovettM, BrysonY J, KleinR J, Friedman-KienA E

Genital herpes treatment

This study investigated the effectiveness and safety of intravenous acyclovir in treating first-time genital herpes outbreaks. The study aimed to confirm previous findings, assess the impact of intravenous acyclovir on future outbreaks, and gain a better understanding of the natural course of genital herpes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

16.

Effect of recombinant interferon alpha 2 on clinical course of first episode genital herpes infection and subsequent recurrences.

Author: MendelsonJ, ClecnerB, EileyS

Reduced healing time
Reduced viral shedding

Interferon treatment for first episodes of genital herpes did not impact symptom duration. However, interferon reduced healing time and viral shedding during recurrences for men, but not for women.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Long-term oral acyclovir treatment prevents recurrent genital herpes.

Author: BlomI, BäckO, EgelrudT, FrödinT, HellbeL, JohannissonG, Malmros-EnanderI, MolinL

Suppressed genital herpes
Relapses

A study of 33 patients with frequently recurring genital herpes found that acyclovir effectively suppressed the disease, but recurrences resumed at the same rate once treatment stopped.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Chronic suppression for six months compared with intermittent lesional therapy of recurrent genital herpes using oral acyclovir: effects on lesions and nonlesional prodromes.

Author: SacksS L, FoxR, LevenduskyP, StiverH G, RolandS, Nusinoff-LehrmanS, KeeneyR

Genital herpes treatment

A study of 47 patients with frequently recurring genital herpes found that oral acyclovir was effective in reducing outbreaks for at least six months. While acyclovir significantly delayed the first recurrence, the effect did not persist after treatment stopped.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Acyclovir in first attacks of genital herpes and prevention of recurrences.

Author: MindelA, WellerI V, FahertyA, SutherlandS, FiddianA P, AdlerM W

Reduced recurrence frequency

A study of 60 patients with first-time genital herpes found that oral acyclovir for 42 days was more effective in delaying the first recurrence compared to a 5-day course of acyclovir followed by placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Efficacy of oral treatment with acyclovir and co-trimoxazole in first episode genital herpes.

Author: KinghornG R, AbeywickremeI, JeavonsM, RowlandM, BartonI, Al-HasaniG, PotterC W, HickmottE

Improved healing time
Reduced pain
Reduced viral shedding

A study of 40 patients with first-episode genital herpes found that oral acyclovir was more effective than placebo in reducing symptoms and accelerating healing. The combination of acyclovir and co-trimoxazole showed potential benefits in women, but neither drug affected subsequent recurrence rates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Efficacy of combined treatment with oral and topical acyclovir in first episode genital herpes.

Author: KinghornG R, AbeywickremeI, JeavonsM, BartonI, PotterC W, JonesD, HickmottE

Reduced itching

A study of 50 patients with first-episode genital herpes found no significant benefit from combining oral acyclovir with topical acyclovir cream.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Topical heparin for recurrent genital herpes simplex virus infections. A proposed model for subsequent therapeutic trials.

Author: GrossmanJ H, Thonnard-NeumannE

Improved genital herpes treatment

A study compared the effectiveness of topical heparin to placebo for recurrent genital herpes simplex virus (HSV) infections. The study was designed to serve as a model for others interested in studying outpatient treatment for genital HSV.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Recurrent genital herpes suppressed by oral acyclovir: a multicentre double blind trial.

Author: ThinR N, JeffriesD J, TaylorP K, AyraO P, RodinP, YeoJ, FiddianA P

Genital herpes treatment

A study of 88 patients with frequent genital herpes found that taking acyclovir (200 mg four times daily) for 84 days significantly reduced the number of outbreaks compared to placebo. Only 13% of patients on acyclovir developed lesions, compared to 88% on placebo. The drug was well-tolerated, and while the time to recurrence after treatment ended was similar for both groups, the study suggests that continuous acyclovir therapy may be helpful for preventing outbreaks during specific times, such as during exams or vacations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Treatment of recurrent genital herpes simplex infections with oral acyclovir.

Author: Ruhnek-ForsbeckM, SandströmE, AnderssonB, ErikssonG, HersleK, LövhagenG B, MobackenH, HillströmL, SvenssonL

Reduced healing time
Reduced symptom duration

A study of 113 patients with recurrent genital herpes found that acyclovir significantly reduced the duration of herpes outbreaks compared to placebo. Acyclovir shortened the time to crusting and healing, as well as the duration of symptoms and new lesions. Acyclovir was well-tolerated with no significant side effects. The study suggests that early treatment with acyclovir may stop herpes outbreaks before they progress to more severe stages.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Acyclovir prophylaxis of recurrent genital herpes: randomised placebo controlled crossover study.

Author: KinghornG R, JeavonsM, RowlandM, AbeywickremeI, BartonI G, PotterC W, HickmottE A

Recurrent herpes prevented
Safe treatment
Treatment withdrawal

A study of 40 patients with recurrent genital herpes found that taking acyclovir (200 mg four times daily) for 84 days significantly reduced the frequency of outbreaks compared to placebo. Only 3 out of 28 patients on acyclovir experienced a recurrence during treatment, compared to 26 out of 28 on placebo. The mean time to the first recurrence was over 84 days for acyclovir and 24 days for placebo. Acyclovir was well-tolerated, with only minor side effects. While acyclovir was effective in reducing outbreaks during treatment, it did not change the natural course of the disease after stopping treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Oral acyclovir in the suppression of recurrent non-genital herpes simplex virus infection.

Author: Meyrick ThomasR H, DoddH J, YeoJ M, KirbyJ D

Herpes treatment

A study of 11 patients with frequent non-genital herpes simplex virus (HSV) outbreaks found that oral acyclovir significantly reduced the number of outbreaks compared to placebo. Only 2 patients experienced an outbreak while taking acyclovir for up to 12 weeks, compared to 9 on placebo. While acyclovir effectively prevented lesions, some patients still experienced prodromal symptoms or erythema. The time to the next outbreak after stopping treatment was similar for both groups. The study concludes that acyclovir is effective and well-tolerated in suppressing recurrent non-genital HSV infections in people with healthy immune systems.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Double-blind placebo-controlled trial of oral acyclovir in first-episode genital herpes simplex virus infection.

Author: MertzG J, CritchlowC W, BenedettiJ, ReichmanR C, DolinR, ConnorJ, RedfieldD C, SavoiaM C, RichmanD D, TyrrellD L

Accelerated healing
Reduced duration of viral shedding
Reduced symptom duration

A study of 150 patients with first-episode genital herpes found that oral acyclovir significantly shortened the duration of viral shedding, symptoms, and healing for patients with primary genital herpes. It did not affect subsequent recurrences.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

28.

Efficacy of oral acyclovir in the treatment of initial and recurrent genital herpes.

Author: NilsenA E, AasenT, HalsosA M, KingeB R, TjøttaE A, WikströmK, FiddianA P

Reduced symptoms
Reduced viral shedding
Well tolerated

A study of 116 patients with genital herpes compared acyclovir to placebo for treating both initial and recurrent outbreaks. Acyclovir significantly reduced the duration of viral shedding, itching, pain, and healing time in patients experiencing their first outbreak. Acyclovir also reduced the duration of viral shedding and healing time in patients with recurrent outbreaks. Both acyclovir and placebo groups reported similar side effects. The study concludes that oral acyclovir is an effective and safe treatment for both initial and recurrent genital herpes outbreaks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

Prophylactic oral acyclovir in recurrent genital herpes.

Author: MindelA, WellerI V, FahertyA, SutherlandS, HindleyD, FiddianA P, AdlerM W

Effective treatment
Reduced recurrence rate

A study of 56 patients with frequently recurring genital herpes found that oral acyclovir significantly reduced the frequency and time to recurrence compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

Intravenous acyclovir for the treatment of primary genital herpes.

Author: CoreyL, FifeK H, BenedettiJ K, WinterC A, FahnlanderA, ConnorJ D, HintzM A, HolmesK K

Improved healing time
Reduced complications
Reduced symptom duration
Reduced viral shedding

A study of 31 patients with first-episode genital herpes found that intravenous acyclovir significantly reduced viral shedding, symptom duration, and healing time compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

31.

Suppression of frequently recurring genital herpes. A placebo-controlled double-blind trial of oral acyclovir.

Author: StrausS E, TakiffH E, SeidlinM, BachrachS, LiningerL, DiGiovannaJ J, WesternK A, SmithH A, LehrmanS N, Creagh-KirkT

Genital herpes suppression
Drug resistance
Hypersensitivity

Oral acyclovir was effective in suppressing recurrent genital herpes in patients experiencing frequent outbreaks, with significantly fewer recurrences compared to placebo (4/16 vs. 16/16). The treatment was well tolerated, with minimal side effects. However, drug resistance emerged in some patients during treatment, highlighting the need for further research on long-term safety and potential strategies to manage resistance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection.

Author: DouglasJ M, CritchlowC, BenedettiJ, MertzG J, ConnorJ D, HintzM A, FahnlanderA, RemingtonM, WinterC, CoreyL

Genital herpes reduction

Oral acyclovir, administered five or two times daily, significantly reduced the frequency and duration of genital herpes recurrences compared to placebo (29% vs. 94% for 5 times daily, 35% vs. 94% for 2 times daily). Acyclovir treatment led to a 50% reduction in recurrence rate for most patients. While not completely preventing recurrences, acyclovir effectively suppressed outbreaks and was well tolerated. The long-term effects on the natural history of the disease require further study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

33.

Topical acyclovir in the treatment of initial genital herpes.

Author: ThinR N, NabarroJ M, ParkerJ D, FiddianA P

Improved healing time
Reduced symptom duration
Reduced viral shedding

A study of 40 patients with initial genital herpes found that topical acyclovir significantly reduced the duration of viral shedding, symptoms, and healing time compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. A randomized double-blind controlled trial in normal subjects.

Author: BrysonY J, DillonM, LovettM, AcunaG, TaylorS, CherryJ D, JohnsonB L, WiesmeierE, GrowdonW, Creagh-KirkT, KeeneyR

Genital herpes treatment

A double-blind, placebo-controlled trial of oral acyclovir for first episodes of genital herpes in 48 young adults showed significant benefits for acyclovir recipients, including reduced virus shedding, new lesion formation, and duration of genital lesions. Symptoms like pain, adenopathy, dysuria, and malaise were also significantly reduced in both men and women. No toxicity was observed, but recurrence rates were similar in both groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

35.

Genital herpes - the disease and its treatment including intravenous acyclovir.

Author: MindelA, SutherlandS

Improved healing time
Reduced symptom duration
Reduced viral shedding

This paper reviews the natural history of genital herpes, previous treatment options, and a double-blind placebo-controlled trial of intravenous acyclovir for severe first-episode genital herpes. Intravenous acyclovir was effective in reducing symptoms and duration of lesions, but did not prevent subsequent recurrences.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

36.

Current status and prospects for oral acyclovir treatment of first episode and recurrent genital herpes simplex virus.

Author: BrysonY J

Improved healing time
Reduced symptom duration
Reduced viral shedding

Oral acyclovir was found to be effective in treating both primary and recurrent genital herpes, significantly reducing viral shedding, lesion formation, and symptom duration compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

37.

Topical acyclovir in the treatment of genital herpes: a comparison with systemic therapy.

Author: FiddianA P, KinghornG R, GoldmeierD, ReesE, RodinP, ThinR N, de KonigG A

Improved healing time
Reduced symptom duration
Reduced viral shedding

Topical acyclovir cream was effective in treating both initial and recurrent genital herpes, reducing symptoms, healing time, and viral shedding compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

38.

Treatment of recurrent genital herpes simplex infections with oral acyclovir. A controlled trial.

Author: ReichmanR C, BadgerG J, MertzG J, CoreyL, RichmanD D, ConnorJ D, RedfieldD, SavoiaM C, OxmanM N, BrysonY

Genital herpes treatment

Oral acyclovir effectively shortened the duration of virus shedding and healing time in patients with recurrent genital herpes. Self-initiated therapy early in the course of a recurrent episode showed even greater benefits.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

39.

Oral acyclovir in the treatment of genital herpes. Preliminary report of a multicenter trial.

Author: FiddianA P, HalsosA M, KingeB R, NilsenA E, WikstromK

Improved healing time
Prevented new lesion formation
Reduced symptom duration

A study of 90 patients with genital herpes (29 initial and 61 recurrent episodes) compared oral acyclovir to placebo. Patients with initial infections who received acyclovir had significantly shorter durations of viral shedding, pain, symptom duration, time to crusting, and time to complete healing compared to those receiving placebo. Similarly, patients with recurrent infections receiving acyclovir experienced shorter durations of viral shedding, time to crusting (in men), and time to complete healing compared to those receiving placebo. Acyclovir was also effective in preventing new lesion formation in both initial and recurrent infections. Oral acyclovir was well-tolerated and shortened the course of both initial and recurrent genital herpes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

Intravenous acyclovir in genital herpes. An interim report.

Author: MindelA, AdlerM W, SutherlandS, FiddianA P

Improved healing time
Reduced symptom duration

A study of 25 patients with primary genital herpes compared intravenous acyclovir to placebo. The acyclovir group showed a significant reduction in the median time to healing of all lesions (11 days to 7 days), the median duration of viral shedding (8 days to 2 days), and the time to cessation of new lesions (2 days to 0 days). These findings indicate that intravenous acyclovir effectively reduces the severity and duration of primary genital herpes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

41.

Human leukocyte interferon-alpha in cream for the management of genital herpes in Asian women: a placebo-controlled, double-blind study.

Author: SyedT A, LundinS, CheemaK M, KahlonR C, KhayyamiM, AhmadS A, AhmadS H, KahlonB M, KahlonA M

Faster healing
Fewer side effects
Shorter duration of viral shedding

This double-blind, placebo-controlled study of 60 patients with first episodes of genital herpes found that human leukocyte interferon-alpha cream was significantly more effective than placebo in reducing viral shedding and healing time.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

Intravenous immunoglobulins suppress the recurrences of genital herpes simplex virus: a clinical and immunological study.

Author: MasciS, De SimoneC, FamularoG, GravanteM, CiancarelliM, AndreassiM, AmerioP, SantiniG

Minor severity of lesions
Reduced frequency of recurrences
Shorter duration of lesions

This study of patients with very high frequency of genital herpes simplex virus (HSV) recurrences found that intravenous immunoglobulins (IVIG) were more effective than intermittent oral acyclovir in reducing the frequency, duration, and severity of recurrences.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

43.

Placebo-controlled trial of vaccination with recombinant glycoprotein D of herpes simplex virus type 2 for immunotherapy of genital herpes.

Author: StrausS E, CoreyL, BurkeR L, SavareseB, BarnumG, KrauseP R, KostR G, MeierJ L, SekulovichR, AdairS F

Fewer recurrences

This double-blind, placebo-controlled trial of 98 patients with genital herpes found that a vaccine containing recombinant glycoprotein D (gD2) of herpes simplex virus type 2 (HSV-2) was well tolerated and reduced the frequency of symptomatic outbreaks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

44.

Human leukocyte interferon-alpha in cream for the treatment of genital herpes in Asian males. A placebo-controlled, double-blind study.

Author: SyedT A, CheemaK M, KahlonB M, KahlonR C, KhayyamiM, KahlonA M, KahlonM M

Improved understanding of genital herpes

Genital herpes is a common sexually transmitted infection that causes genital sores. It is a recurring condition and can contribute to cervical abnormalities in women and cause neonatal herpes in newborns.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

45.

Valaciclovir versus aciclovir in patient initiated treatment of recurrent genital herpes: a randomised, double blind clinical trial. International Valaciclovir HSV Study Group.

Author: BodsworthN J, CrooksR J, BorelliS, VejlsgaardG, PaavonenJ, WormA M, UexkullN, EsmannJ, StrandA, IngamellsA J, GibbA

Convenient dosing
Effective treatment
Mild adverse events

Valaciclovir 500 mg twice daily is equivalent in efficacy to aciclovir 200 mg five times daily as episodic treatment of recurrent genital HSV infection. Valaciclovir maintains the established efficacy and safety of aciclovir but offers a much more convenient twice daily dosing regimen.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

46.

Safety and efficacy of Virend for topical treatment of genital and anal herpes simplex lesions in patients with AIDS.

Author: Orozco-TopeteR, Sierra-MaderoJ, Cano-DominguezC, KershenovichJ, Ortiz-PedrozaG, Vazquez-VallsE, Garcia-CosioC, Soria-CordobaA, ArmendarizA M, Teran-ToledoX, Romo-GarciaJ, FernandezH, RozhonE J

Genital herpes treatment

This study evaluated the safety and effectiveness of Virend (SP-303), a new topical antiviral agent, for treating recurrent genital herpes lesions in patients with AIDS. Virend showed promise in promoting healing and reducing viral cultures.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

A randomized, placebo-controlled comparison of oral valacyclovir and acyclovir in immunocompetent patients with recurrent genital herpes infections. The Valaciclovir International Study Group.

Author: TyringS K, DouglasJ M, CoreyL, SpruanceS L, EsmannJ

Valacyclovir effective
Valacyclovir well tolerated

Valacyclovir hydrochloride twice daily was as effective and well-tolerated as acyclovir five times daily in treating recurrent genital herpes simplex virus infection. Valacyclovir offers a convenient dosing alternative when compliance is a concern.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

Advances in the treatment of herpesvirus infection: the role of famciclovir.

Author: TyringS K

Improved herpes zoster and genital herpes treatment

Shingles, caused by reactivation of the chickenpox virus, can cause significant pain and lead to a long-term complication called postherpetic neuralgia, which affects 3.4 people per 1,000 each year. Genital herpes, caused by a different type of herpes virus, can cause recurrent outbreaks multiple times per year for some people. Antiviral medications like famciclovir, valacyclovir, and acyclovir can reduce the severity and duration of these conditions, and may even prevent future outbreaks of genital herpes. This review summarizes the causes of shingles and genital herpes and discusses 12 studies demonstrating the effectiveness of famciclovir in treating both conditions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

49.

A comparison of topical application of penciclovir 1% cream with acyclovir 3% cream for treatment of genital herpes: a randomized, double-blind, multicentre trial.

Author: ChenX S, HanG Z, GuoZ P, LuN Z, ChenJ, WangJ B,

Faster crusting
Improved herpes symptoms
Mild adverse effects

This randomized, double-blind, multicentre trial compared the efficacy of penciclovir 1% cream to acyclovir in treating genital herpes simplex virus (HSV) infection. The study found that penciclovir showed encouraging results, with a shorter time to crusting in patients with primary infections, but no significant differences in overall efficacy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

[Valaciclovir in the treatment of initial infection by genital herpes virus: comparative study].

Author: GarcíaA, GarcíaS, SánchezJ A, GarcíaI, LancharesJ L

Dosing comfort
Herpes treatment
Adverse effects

Acyclovir and valaciclovir were both effective in treating genital herpes. A study involving 142 patients with first-episode genital herpes found that both drugs showed similar efficacy in reducing symptoms and lesions. However, valaciclovir offered greater dosing comfort and ease of treatment completion.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

51.

Two-day regimen of acyclovir for treatment of recurrent genital herpes simplex virus type 2 infection.

Author: WaldAnna, CarrellDavid, RemingtonMichael, KexelElizabeth, ZehJudy, CoreyLawrence

Increased proportion of aborted episodes
Reduced duration of episode
Reduced duration of lesions

A 2-day course of acyclovir was found to be effective in treating recurrent genital herpes, significantly reducing the duration of lesions, episodes, and viral shedding compared to a placebo. It also increased the proportion of aborted episodes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

52.

Aborted genital herpes simplex virus lesions: findings from a randomised controlled trial with valaciclovir.

Author: StrandA, PatelR, WulfH C, CoatesK M,

Aborts HSV lesions
Prevents HSV lesions

Episodic valaciclovir significantly increased the chance of preventing or aborting painful genital herpes simplex virus (HSV) lesions compared to placebo. This study explores the clinical outcome of aborted lesions and its association with early treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

53.

Patients' preference of valacyclovir once-daily suppressive therapy versus twice-daily episodic therapy for recurrent genital herpes: a randomized study.

Author: RomanowskiBarbara, MarinaRaymond B, RobertsJeremy N,

Genital herpes treatment
Well tolerated

Suppressive valacyclovir therapy was preferred by most patients compared to episodic valacyclovir treatment for recurrent genital herpes. Suppressive therapy significantly increased treatment satisfaction and quality of life, while reducing the risk and frequency of recurrences.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.

Language : English

54.

Evaluation of imiquimod 5% cream to modify the natural history of herpes labialis: a pilot study.

Author: BernsteinDavid I, SpruanceSpotswood L, AroraSujata S, SchroederJennifer L, MengTze-Chiang

Herpes treatment

This study investigated the safety and potential of topical imiquimod for reducing the recurrence of herpes labialis in individuals with a history of recurrent outbreaks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

55.

Single-day therapy for recurrent genital herpes.

Author: TyringStephen, BergerTim, Yen-MooreAngela, TharpMichael, HamedKamal

Improved genital herpes treatment
Genital herpes

Genital herpes, an incurable viral infection affecting one in four Americans, can have a significant impact on people's lives. While standard treatment involves antiviral medications for 3-5 days, a single-day treatment may be more effective, as most viral replication occurs within the first 24 hours of symptoms. A study found that single-day famciclovir reduced healing time, pain duration, and the number of patients experiencing a full outbreak compared to placebo. The results were comparable to or better than conventional 2-5 day treatments. The convenience of single-day treatment could encourage patients to use it more consistently, improving overall management of recurrent outbreaks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

56.

A comparison of one year of episodic or suppressive treatment of recurrent genital herpes with valacyclovir.

Author: FifeKenneth H, AlmekinderJennifer, OfnerSusan

Improved quality of life
Reduced outbreaks

Suppressive therapy with valacyclovir had a greater impact on measures of disease frequency and burden in patients with recurrent genital herpes than episodic therapy. Both treatment strategies lead to significant improvements in quality-of-life scores.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

57.

A meta-analysis to assess the efficacy of oral antiviral treatment to prevent genital herpes outbreaks.

Author: Lebrun-VignesBénédicte, BouzamondoAnissa, DupuyAlain, GuillaumeJean-Claude, LechatPhilippe, ChosidowOlivier

Genital herpes recurrence prevention

Oral acyclovir, valacyclovir (VACV), or famciclovir are highly effective for prophylaxis against recurrent genital herpes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

58.

Famciclovir treatment options for patients with frequent outbreaks of recurrent genital herpes: the RELIEF trial.

Author: BartlettBrenda L, TyringStephen K, FifeKenneth, GnannJohn W, HadalaJoseph T, KianifardFarid, BerberErhan

Extended time to outbreaks

Suppressive treatment with oral famciclovir extended the time to symptomatic outbreaks in patients with frequent recurrences of genital herpes compared to episodic treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

59.

Single-day, patient-initiated famciclovir therapy versus 3-day valacyclovir regimen for recurrent genital herpes: a randomized, double-blind, comparative trial.

Author: AbudaluMohammed, TyringStephen, KoltunWilliam, BodsworthNeil, HamedKamal

Herpes treatment

This study compared single-day famciclovir to 3-day valacyclovir for episodic therapy of recurrent genital herpes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

60.

2-day versus 5-day famciclovir as treatment of recurrences of genital herpes: results of the FaST study.

Author: BodsworthNeil, BlochMark, McNultyAnna, DenhamIan, DoongNicholas, TrottierSylvie, AdenaMichael, BonneyMary-Ann, AgnewJames,

Effective treatment for herpes
Improved patient compliance
Shorter treatment duration

A 2-day course of famciclovir was as safe and effective as the standard 5-day course in treating recurrent genital herpes lesions. Both treatments resulted in similar rates of lesion healing and side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

61.

Single-day famciclovir for the treatment of genital herpes: follow-up results of time to next recurrence and assessment of antiviral resistance.

Author: BodsworthNeil, FifeKenneth, KoltunWilliam, TyringStephen, AbudaluMohammed, PrichardMark, HamedKamal

Effective herpes treatment
Antiviral resistance

Treatment for genital herpes is usually short-term for people who have infrequent outbreaks and aren't concerned about spreading the infection. While shorter courses of treatment are as effective as the standard 5-day regimen, it is unknown if shorter treatment affects the long-term course of the infection or increases the risk of drug resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

62.

One-day famciclovir vs. placebo in patient-initiated episodic treatment of recurrent genital herpes in immunocompetent Black patients.

Author: LeonePeter, AbudaluMohamed, MithaEssack, GaniMashra, ZhouWenchun, HamedKamal

RGH treatment

While there is no evidence that race affects how genital herpes develops or responds to treatment, clinical trials on recurrent genital herpes (RGH) often include a small number of Black participants, despite high rates of herpes infection in this population.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

63.

[Synergetic effect of self-prescribed decoction eliminating herpes in treatment of recurrent genital herpes].

Author: ChengGui-ming

Increased effectiveness
Reduced recurrence rate

A self-prescribed decoction eliminating herpes combined with recombinant human interleukin-2 (IL-2) was effective in treating recurrent genital herpes and significantly decreased recurrence rates.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

64.

Genital herpes: oral antiviral treatments.

Author: HollierLisa M, EppesCatherine

A systematic review of 8 studies found that aciclovir, famciclovir, and valaciclovir are effective treatments for genital herpes. The choice of antiviral depends on individual factors and the severity of infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Interventions for men and women with their first episode of genital herpes.

Author: HeslopRachel, RobertsHelen, FlowerDeralie, JordanVanessa

Reduced symptom duration
Adverse events

Oral acyclovir was found to reduce the duration of symptoms for first-episode genital herpes, but the evidence was of low quality due to limitations in the included studies. There was no evidence that topical antivirals reduced symptom duration for patients with first-episode genital herpes. Further research is needed to provide more conclusive evidence on the effectiveness of various treatments for first-episode genital herpes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

Clinical Trial of Herbal Treatment Gene-Eden-VIR/Novirin in Oral Herpes.

Author: PolanskyHanan, JavaherianAdrian, ItzkovitzEdan

Genital herpes treatment
Oral herpes treatment

This study explores the effectiveness of Gene-Eden-VIR/Novirin, a herbal treatment, in reducing the number and duration of oral herpes outbreaks, comparing it to acyclovir, valacyclovir, and famciclovir drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

67.

Diagnosis and Management of Genital Herpes: Key Questions and Review of the Evidence for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.

Author: JohnstonChristine

Management of genital herpes infection

This systematic review informed the 2021 Centers for Disease Control and Prevention (CDC) STI treatment guidelines for genital herpes infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

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