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Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: Attenuation by α-tocopherol.

Author: CacciaClaudio, Cherkaoui-MalkiMustapha, LeoniValerio, LizardGérard, MeddebWiem, MihoubiWafa, MoreauThibault, MénétrierFranck, NamsiAmira, NuryThomas, RiedingerJean-Marc, SassiKhouloud, SghaierRanda, UzunTugba, VejuxAnne, ZarroukAmira

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the role of peroxisomes in cell death induced by 7-ketocholesterol (7KC) in murine oligodendrocytes. 7KC triggered morphological, topographical, and functional peroxisomal alterations, associated with mitochondrial dysfunction and oxidative stress. 7KC also induced pexophagy, a process of autophagic degradation of peroxisomes. These findings suggest a role for peroxisomes in 7KC-induced cell death.
Paper Details　
Original Abstract of the Article :
The involvement of organelles in cell death is well established especially for endoplasmic reticulum, lysosomes and mitochondria. However, the role of the peroxisome is not well known, though peroxisomal dysfunction favors a rupture of redox equilibrium. To study the role of peroxisomes in cell deat...See full text at original site
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引用元：
https://doi.org/10.1016/j.biochi.2018.07.009

データ提供：米国国立医学図書館（NLM）

Exploring the Peroxisome's Role in Oligodendrocyte Health

The intricate world of cell health is a vast desert, with numerous organelles playing vital roles in maintaining cellular harmony. This research, like a curious explorer, focuses on the often-overlooked peroxisome and its potential involvement in cell death, particularly in oligodendrocytes.

The study investigates the effects of 7-ketocholesterol (7KC), a cholesterol oxidation product, on peroxisome function in oligodendrocytes, examining the potential for 7KC to induce peroxisomal dysfunction and contribute to cell death. The findings reveal a complex interplay between 7KC, peroxisomes, and mitochondrial function, providing valuable insight into the role of peroxisomes in maintaining oligodendrocyte health.

Unveiling the Secrets of the Peroxisome

The study suggests that 7KC can disrupt peroxisome function in oligodendrocytes, leading to morphological and functional alterations. It highlights the importance of maintaining peroxisome health for optimal oligodendrocyte function and survival. Furthermore, the study reveals the protective effects of α-tocopherol (vitamin E) in mitigating 7KC-induced peroxisomal changes.

Navigating the Desert of Cell Health

This research underscores the critical role of peroxisomes in maintaining cell health, particularly in oligodendrocytes, which are vital for the formation and maintenance of myelin, the protective sheath around nerve fibers. The findings highlight the potential for targeting peroxisome function as a therapeutic approach in conditions affecting oligodendrocytes.

Dr. Camel's Conclusion

This study takes us on an exciting journey into the often-neglected world of peroxisomes, revealing their crucial role in maintaining cell health. It underscores the potential for targeting peroxisome dysfunction as a therapeutic strategy, highlighting the need for further research to unravel the intricate mechanisms that govern peroxisome function and its impact on cellular well-being.

Date :
  1. Date Completed 2018-12-11
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

30031877

DOI: Digital Object Identifier

10.1016/j.biochi.2018.07.009

Related Literature

Article Analysis
・Side Effects of alpha-tocopherol
SNS
PICO Info
in preparation
Languages

English

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