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Amisulpride and olanzapine followed by open-label treatment with clozapine in first-episode schizophrenia and schizophreniform disorder (OPTiMiSE): a three-phase switching study.

Author: , ArangoCelso, DazzanPaola, DrakeRichard, Díaz-CanejaCovadonga M, EijkemansMarinus J C, FleischhackerW Wolfgang, GalderisiSilvana, GlenthøjBirte, HeresStephan, KahnRené S, KapurShitij, LeboyerMarion, LeuchtStefan, LewisShon W, McGuirePhilip, RujescuDan, SommerIris E, WeiserMark, Winter van RossumInge

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A simple treatment algorithm using sequential administration of amisulpride and clozapine achieved symptomatic remission in most patients in the early stages of schizophrenia. Switching to olanzapine did not improve outcome, suggesting that clozapine should be used after patients fail a single antipsychotic trial, not after two.
Paper Details　
Original Abstract of the Article :
BACKGROUND: No established treatment algorithm exists for patients with schizophrenia. Whether switching antipsychotics or early use of clozapine improves outcome in (first-episode) schizophrenia is unknown. METHODS: This three-phase study was done in 27 centres, consisting of general hospitals and...See full text at original site
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引用元：
https://doi.org/10.1016/S2215-0366(18)30252-9

データ提供：米国国立医学図書館（NLM）

Treating First-Episode Schizophrenia: A Sequential Antipsychotic Approach

The world of mental health is a complex and often challenging landscape for both patients and healthcare providers. This study investigates a sequential antipsychotic treatment approach for individuals experiencing a first episode of schizophrenia. The authors explore the effectiveness of using amisulpride followed by clozapine, a commonly used antipsychotic medication, in managing this condition.

A Promising Treatment Algorithm for First-Episode Schizophrenia

The study, involving 481 participants across 27 centers, demonstrates that a sequential approach using amisulpride and clozapine can effectively achieve symptomatic remission in a significant portion of individuals with first-episode schizophrenia. The findings suggest that clozapine may be a valuable tool for managing schizophrenia after initial treatment with amisulpride has failed. This research adds to the growing body of evidence supporting the use of clozapine in managing resistant schizophrenia.

The Potential of Sequential Treatment Approaches

This research highlights the potential of sequential treatment approaches in managing mental health conditions. By carefully selecting and tailoring medications based on individual patient needs and response to treatment, healthcare providers can optimize patient outcomes and improve the overall quality of life for individuals with mental illness. This approach mirrors the journey of a camel through the desert, where each step is carefully considered and adapted to the ever-changing landscape.

Dr. Camel's Conclusion

This study offers a glimmer of hope for individuals struggling with first-episode schizophrenia. The sequential treatment approach, combining amisulpride and clozapine, demonstrates a promising pathway to achieving symptomatic remission and improving overall quality of life. As we continue to explore the complex world of mental health, we must embrace innovative approaches, like the careful steps of a camel traversing the desert, to navigate the challenges and seek solutions for those in need.

Date :
  1. Date Completed 2019-08-09
  2. Date Revised 2022-07-20
Further Info :

Pubmed ID

30115598

DOI: Digital Object Identifier

10.1016/S2215-0366(18)30252-9

Related Literature

Article Analysis
・Effective treatment of schizophrenia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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