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A primary undifferentiated pleomorphic sarcoma of the lumbosacral region harboring a LMNA-NTRK1 gene fusion with durable clinical response to crizotinib: a case report.

Author: FangMeiyu, LiTao, LiuLuying, SchäferReinhold, ZhouNing

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

High-grade spindle cell sarcomas are a rare type of cancer that is difficult to diagnose. These cancers are very aggressive and have a poor prognosis. More research is needed to understand how to treat them effectively.
Paper Details　
Original Abstract of the Article :
High-grade spindle cell sarcomas are a subtype of rare, undifferentiated pleomorphic sarcomas (UPSs) for which diagnosis is difficult and no specific treatment strategies have been established. The limited published data on UPSs suggest an aggressive clinical course, high rates of local recurrence a...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106902/

データ提供：米国国立医学図書館（NLM）

Undifferentiated Pleomorphic Sarcoma: A Rare and Challenging Tumor

Undifferentiated pleomorphic sarcoma (UPS), a rare and aggressive type of cancer, presents a significant challenge for clinicians. This case report details an unusual case of UPS in the lumbosacral region harboring a LMNA-NTRK1 gene fusion. The patient exhibited a durable clinical response to crizotinib, an FDA-approved drug for treating certain types of cancer.

A Glimpse into the Potential of Targeted Therapy

This case report offers a promising glimpse into the potential of targeted therapies for treating UPS. The discovery of a specific gene fusion and the subsequent response to crizotinib suggests that future research should explore individualized treatment strategies based on the unique genetic characteristics of each tumor.

Living with Sarcoma: Seeking Hope and Navigating Treatment

Sarcoma, a type of cancer that originates in connective tissues, can be a devastating diagnosis. This case report underscores the importance of seeking comprehensive medical care and exploring all available treatment options. Advances in targeted therapies offer a glimmer of hope for individuals facing this challenge.

Dr.Camel's Conclusion

The case report offers a valuable lesson in the realm of personalized medicine. Just as a camel adapts to its unique desert environment, we must embrace the unique characteristics of each tumor to develop personalized treatment strategies. This case report represents a significant step forward in our fight against this rare and aggressive cancer.

Date :
  1. Date Completed 2018-11-05
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

30134855

DOI: Digital Object Identifier

PMC6106902

Related Literature

Article Analysis
・Side Effects of crizotinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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