Systematic review with meta-analysis: risk of adverse cardiovascular events with proton pump inhibitors independent of clopidogrel.

Author: BatchelorRiley, Gilmartin-ThomasJulia F M, HopperIngrid, KempWilliam, KumarRadya, LiewDanny

Paper Details 
Original Abstract of the Article :
Clopidogrel's anti-platelet effects may be attenuated by a pharmacokinetic interaction with co-prescribed proton pump inhibitors, which inhibit oxidative pathways that convert clopidogrel into its active metabolites. Despite this, the impact of PPIs on cardiovascular risk in the absence of clopidogr...See full text at original site
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引用元:
https://doi.org/10.1111/apt.14955

データ提供:米国国立医学図書館(NLM)

Proton Pump Inhibitors and Cardiovascular Risk

Proton pump inhibitors (PPIs) are commonly used to treat [acid reflux] and other [gastrointestinal conditions], but their impact on [cardiovascular health] has been a subject of ongoing research. This study examines the potential link between [PPIs] and [adverse cardiovascular events], focusing on the possible interaction between [PPIs] and [clopidogrel], a common [anti-platelet drug]. The researchers conducted a systematic review and meta-analysis of existing studies and found that [PPIs] may increase the risk of [adverse cardiovascular events], even in the absence of [clopidogrel] use. These findings highlight the need for caution when prescribing [PPIs] and underscore the importance of considering individual patient risk factors.

Balancing Stomach Health and Heart Health

This study highlights the importance of a holistic approach to patient care, considering the potential impact of medications on various aspects of health. The findings suggest that [PPIs] may not be as innocuous as previously thought and that careful consideration of individual patient risk factors is crucial before prescribing them. This research emphasizes the need for a nuanced understanding of the interactions between different medications and their potential impact on overall health.

Navigating the World of Medications with Awareness

Just as a camel needs to be aware of its surroundings to avoid dangers in the desert, we must be mindful of the potential side effects of medications, even those that are commonly used. This study serves as a reminder that even seemingly harmless medications can have unexpected consequences.

Dr.Camel's Conclusion

This study underscores the importance of carefully weighing the risks and benefits of medications, even those that are commonly used. It highlights the need for a holistic approach to patient care, considering the potential impact of medications on various aspects of health. Just as a camel navigates the desert with awareness and caution, we must approach medication use with vigilance and a commitment to understanding the potential consequences.

Date :
  1. Date Completed 2019-09-09
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

30178881

DOI: Digital Object Identifier

10.1111/apt.14955

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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