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Effects of 9-cis-retinoic acid on the proliferation and apoptosis of cutaneous T-cell lymphoma cells.

Author: DiaoQingchun, LiLingjun, MaPengcheng, TaoYue, YangHua, ZhangMengli

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

9-cis-retinoic acid (9-cis-RA) is a vitamin A derivative used for treating cutaneous T-cell lymphoma (CTCL). Studies show that 9-cis-RA inhibits cell proliferation and induces apoptosis in CTCL cells. This effect is mediated by the inhibition of the JAK/STAT pathway and activation of the RAR/RXR pathway.
Paper Details　
Original Abstract of the Article :
The vitamin A derivative 9-cis-retinoic acid (9-cis-RA) has been used for the treatment and prevention of cutaneous T-cell lymphoma (CTCL). However, the precise mechanism by which 9-cis-RA treatment ameliorates CTCL remains elusive. Our research shows that 9-cis-RA inhibits proliferation and induces...See full text at original site
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引用元：
https://doi.org/10.1097/CAD.0000000000000692

データ提供：米国国立医学図書館（NLM）

9-cis-Retinoic Acid: A Potential Weapon Against Cutaneous T-Cell Lymphoma

Cutaneous T-cell lymphoma (CTCL) is a type of skin cancer. Scientists are always searching for new and effective treatments. 9-cis-retinoic acid (9-cis-RA), a derivative of vitamin A, has shown promise in treating and preventing CTCL. This study investigates the specific mechanisms by which 9-cis-RA combats CTCL.

How 9-cis-RA Fights CTCL Cells

The researchers discovered that 9-cis-RA inhibits the growth of CTCL cells and triggers their self-destruction (apoptosis). This effect is dose-dependent and time-dependent. It also interrupts the cell cycle, preventing cells from dividing and growing. Importantly, 9-cis-RA blocks the JAK/STAT signaling pathway, which plays a crucial role in cell growth and survival.

Hope for CTCL Patients

This research suggests that 9-cis-RA holds potential as a chemotherapy agent for CTCL. It may also prevent the development of this type of cancer by inhibiting cell growth and inducing apoptosis. This opens the door for new and effective treatment strategies for CTCL patients.

Dr.Camel's Conclusion

This research provides a detailed understanding of how 9-cis-RA combats CTCL. It unveils the complex mechanisms involved, highlighting the potential of this vitamin A derivative as a promising treatment option for CTCL.

Date :
  1. Date Completed 2020-06-02
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

30198914

DOI: Digital Object Identifier

10.1097/CAD.0000000000000692

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Languages

English

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