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[Value of combining biologics with methotrexate for treatment of psoriatic arthritis-questions remain].

Author: BehrensF, BurkhardtH, DauthS, HerrmannE, KöhmM, LehnA, RossmanithT

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Methotrexate (MTX) can improve the effectiveness of biologic medications for rheumatoid arthritis. However, it's unclear if the same is true for psoriatic arthritis (PsA), as research is limited. We know that people with PsA who don't respond well to MTX or other pain relievers alone can benefit from biologic treatments.
Paper Details　
Original Abstract of the Article :
Concomitant methotrexate (MTX) improves the therapeutic effect of biologic therapies in rheumatoid arthritis treatment. However, the influence of MTX on biologic therapy in psoriasis arthritis (PsA) has not yet been fully clarified, as data from randomized clinical studies are lacking. So far, it is...See full text at original site
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引用元：
https://doi.org/10.1007/s00393-018-0533-3

データ提供：米国国立医学図書館（NLM）

The Complexities of Psoriatic Arthritis Treatment

The quest for effective treatments for psoriatic arthritis (PsA) continues to evolve. This study investigates the potential benefits of combining biologics with methotrexate (MTX) for PsA management. While the combination of these medications has been shown to be effective in rheumatoid arthritis, the evidence supporting its use in PsA remains limited. The authors highlight the need for further research to definitively establish the role of MTX in enhancing the therapeutic effects of biologics in PsA.

The Search for Optimal PsA Treatment

The study emphasizes the need for more robust clinical trials to clarify the potential advantages of combining biologics with MTX for PsA. The findings suggest that while MTX may play a role in improving response to biologics, more data is required to establish clear guidelines for treatment optimization.

Navigating the Challenges of PsA Treatment

Psoriatic arthritis presents a unique set of challenges for patients and healthcare providers. This study highlights the importance of personalized treatment approaches, considering individual patient characteristics, response to therapy, and potential side effects.

Dr. Camel's Conclusion

Finding the right treatment for PsA is like navigating a shifting desert landscape. The combination of biologics and MTX may offer a promising path, but further research is needed to ensure its effectiveness and safety. Remember, finding the right oasis requires careful observation, a willingness to adapt, and a commitment to finding the best possible solution for your unique needs.

Date :
  1. Date Completed 2019-09-11
  2. Date Revised 2019-09-11
Further Info :

Pubmed ID

30203153

DOI: Digital Object Identifier

10.1007/s00393-018-0533-3

Related Literature

Article Analysis
・Effective treatment of psoriatic arthritis
SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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