Daily or on-demand oral tenofovir disoproxil fumarate/emtricitabine for HIV pre-exposure prophylaxis: experience from a hospital-based clinic in France.

Author: AslanAlexandre, BalavoineStéphanie, BauerRebecca, BrunAlexandre, DelaugerreConstance, LeplatoisAnne, LozeBénédicte, MolinaJean-Michel, MoudachirouKhafil, NoretMarion, PintadoClaire, RozenbaumWilly, SiguierMartin

Paper Details 
Original Abstract of the Article :
BACKGROUND: On-demand oral tenofovir disoproxil fumarate and emtricitabine (TDF/FTC) has been approved for pre-exposure prophylaxis (PrEP) in MSM in France following the results of clinical studies, but data are limited on real-world experience. DESIGN: A single-center, open-label, prospective coho...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/30212403

データ提供:米国国立医学図書館(NLM)

Tenofovir Disoproxil Fumarate/Emtricitabine for HIV PrEP: A New Oasis in the Desert of Prevention

HIV prevention is a critical public health priority, and pre-exposure prophylaxis (PrEP) offers a powerful tool for reducing the risk of infection. This study explores the real-world experience of using tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) for PrEP in a hospital-based clinic in France. The researchers conducted a prospective cohort study involving 1049 patients, offering both daily and on-demand PrEP regimens. The findings demonstrate a low HIV incidence among PrEP users, with only four HIV infections diagnosed over 486 person-years of follow-up. The study also observed an increase in condomless sex among PrEP users, suggesting that PrEP may facilitate riskier sexual behaviors. This is like discovering a new oasis in the desert of HIV prevention, offering a potentially effective but complex strategy for reducing the risk of infection.

The Oasis of PrEP: A New Era of HIV Prevention

The study's findings provide encouraging evidence for the effectiveness of TDF/FTC for PrEP, highlighting its potential to reduce HIV incidence and improve public health outcomes. This discovery is like finding a hidden spring in the desert, offering a refreshing and sustainable source of hope for those at risk of HIV infection.

Navigating the Desert of HIV Prevention: Balancing Benefits and Risks

The study highlights the importance of careful consideration of the potential benefits and risks of PrEP, emphasizing the need for comprehensive counseling and ongoing monitoring to ensure safe and effective use. This research is like exploring a vast desert, where navigating the complexities of HIV prevention requires careful planning and a balanced approach.

Dr. Camel's Conclusion

The study on TDF/FTC for PrEP offers valuable insights into the real-world effectiveness and potential challenges of this important HIV prevention strategy. This research is a testament to the ongoing efforts to find innovative solutions for reducing HIV transmission, offering a glimmer of hope in the vast desert of HIV prevention.

Date :
  1. Date Completed 2019-10-30
  2. Date Revised 2019-10-30
Further Info :

Pubmed ID

30212403

DOI: Digital Object Identifier

00002030-201809240-00008

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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