Paper Details

  1. Home
  2. Paper Details

Bone Microstructure in Response to Vitamin D3 Supplementation: A Randomized Placebo-Controlled Trial.

Author: BislevLise Sofie, Langagergaard RødbroLene, RejnmarkLars, RolighedLars, SikjaerTanja

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the effects of 3 months of daily vitamin D3 supplementation (2800 IU) on bone health in postmenopausal women with low vitamin D levels. Vitamin D supplementation significantly increased vitamin D levels in the blood and decreased PTH levels, but it did not affect overall bone density or bone turnover markers. However, vitamin D3 increased bone density in the hip and improved bone strength and thickness in the lower leg. These improvements were linked to increased vitamin D levels. The study suggests that short-term vitamin D supplementation may have positive effects on bone health, even if it doesn't improve overall bone density.
Paper Details　
Original Abstract of the Article :
Vitamin D supplementation is often used in the prevention and treatment of osteoporosis, but the role of vitamin D has lately been questioned. We aimed to investigate the effect of 3 months of daily vitamin D3 supplementation (70 µg [2800 IU] vs. placebo) initiated in winter months&#1...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s00223-018-0481-6

データ提供：米国国立医学図書館（NLM）

Vitamin D: A Bone-Strengthening Oasis in the Desert?

The role of Vitamin D in bone health has been a topic of great interest, with studies exploring its potential to prevent and treat osteoporosis. This research investigated the effects of daily Vitamin D3 supplementation on bone health in postmenopausal women. The researchers carefully designed a double-blind placebo-controlled trial, a method akin to a camel navigating a maze, ensuring that neither the participants nor the researchers knew who received the active treatment.

Vitamin D: A Boost for Bone Strength, But Not Bone Density

The results revealed that while Vitamin D supplementation significantly increased Vitamin D levels in the blood, it did not affect overall bone density as measured by DXA scans. However, the researchers observed improvements in trabecular bone microarchitecture, which indicates a potential strengthening effect. This suggests that Vitamin D might play a crucial role in maintaining bone health beyond simply increasing density.

Vitamin D: A Vital Nutrient for Bone Health

The study emphasizes the importance of maintaining adequate Vitamin D levels for bone health. While it may not directly impact overall bone density, Vitamin D appears to play a role in improving the microarchitecture of bones, which could contribute to increased strength and reduced fracture risk. This reinforces the need for individuals, especially those with low Vitamin D levels, to consider appropriate supplementation or dietary adjustments.

Dr. Camel's Conclusion

This study illuminates the complex relationship between Vitamin D and bone health. While Vitamin D supplementation may not directly impact bone density, it appears to contribute to bone microarchitecture, suggesting a broader role in maintaining bone strength. This research provides valuable insights for navigating the intricate world of bone health, emphasizing the importance of Vitamin D for overall well-being.

Date :
  1. Date Completed 2020-06-09
  2. Date Revised 2020-06-09
Further Info :

Pubmed ID

30293198

DOI: Digital Object Identifier

10.1007/s00223-018-0481-6

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.