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Statins and Multiple Noncardiovascular Outcomes: Umbrella Review of Meta-analyses of Observational Studies and Randomized Controlled Trials.

Author: BruntEleanor, CampbellHarry, GasevicDanijela, HeYazhou, IoannidisJohn P A, LiXue, McLachlanFiona, MillensonMarisa, TheodoratouEvropi, TimofeevaMaria

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

A review of 278 non-cardiovascular disease outcomes from 112 meta-analyses of observational studies and 144 meta-analyses of randomized controlled trials found no convincing evidence of an association between statins and non-CVD outcomes. Observational studies showed suggestive evidence that statins increase the risk for diabetes and myopathy.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Many effects of statins on non-cardiovascular disease (non-CVD) outcomes have been reported. PURPOSE: To evaluate the quantity, validity, and credibility of evidence regarding associations between statins and non-CVD outcomes and the effects of statins on these outcomes. DATA SOURCES: ...See full text at original site
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引用元：
https://doi.org/10.7326/M18-0808

データ提供：米国国立医学図書館（NLM）

Exploring the Multifaceted Impact of Statins

Statins, often hailed as heroes in the fight against cardiovascular disease, have become ubiquitous in modern medicine. But their effects extend far beyond the realm of the heart, reaching into the intricate workings of the body. This umbrella review synthesizes the available evidence regarding the association between statins and non-cardiovascular outcomes, seeking to map the vast landscape of their potential effects.

Navigating a Sea of Evidence

The researchers analyzed data from 112 meta-analyses of observational studies and 144 meta-analyses of randomized controlled trials, meticulously navigating a sea of research to understand the complex interactions between statins and non-cardiovascular outcomes. Their findings revealed a complex tapestry of associations, with some outcomes showing suggestive evidence of a positive effect, while others indicated potential risks. However, the lack of convincing evidence for a causal link between statins and most non-cardiovascular outcomes suggests that current recommendations regarding their use should remain unchanged.

The Importance of Balanced Perspective

This research reminds us that the benefits of any medication must be weighed against potential risks, a careful balancing act, much like navigating a desert landscape where every step must be carefully considered. It highlights the importance of ongoing research to better understand the intricate effects of medications like statins, ensuring that they are used safely and effectively to optimize patient outcomes.

Dr. Camel's Conclusion

The findings of this umbrella review provide a comprehensive overview of the vast landscape of statin effects, demonstrating the complex interplay between these medications and non-cardiovascular outcomes. It emphasizes the importance of ongoing research to fully understand the potential benefits and risks associated with these widely used medications, allowing us to navigate the desert of medical knowledge with greater clarity and precision, ensuring the well-being of our patients.
Date :
  1. Date Completed 2019-08-23
  2. Date Revised 2021-07-29
Further Info :

Pubmed ID

30304368

DOI: Digital Object Identifier

10.7326/M18-0808

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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