Pazopanib, Cabozantinib, and Vandetanib in the Treatment of Progressive Medullary Thyroid Cancer with a Special Focus on the Adverse Effects on Hypertension.

Author: BauerJohann, GrimmDaniela, GrosseJirka, InfangerManfred, KoppSascha, KrügerMarcus, MillingRikke Vilsbøll, WehlandMarkus

Paper Details 
Original Abstract of the Article :
Medullary thyroid cancer (MTC) is a rare malignancy with a poor prognosis. First line therapy is surgery, which is the only curative method of the disease. However, in non-operable cases or with tumor progression and metastases, a systemic treatment is necessary. This form of cancer is often insensi...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214082/

データ提供:米国国立医学図書館(NLM)

Targeted Therapy for Medullary Thyroid Cancer: Navigating the Shifting Sands of Treatment

The realm of oncology is a vast and ever-shifting desert, and medullary thyroid cancer (MTC) presents a unique challenge. This rare and often aggressive form of cancer can be difficult to treat, with limited options available. However, recent advances in targeted therapies, like tyrosine kinase inhibitors (TKIs), have brought a new sense of hope to the desert landscape. This study dives deep into the use of TKIs, such as pazopanib, cabozantinib, and vandetanib, for the treatment of MTC, exploring their efficacy and potential side effects.

This research acts as a compass, guiding us through the complexities of treating MTC. The study delves into the mechanisms of action of TKIs, highlighting their potential to improve progression-free survival and extend patient lives. However, the study also acknowledges that these powerful medications can sometimes come with side effects, particularly hypertension, which can be as challenging to manage as the cancer itself.

Navigating the Side Effects of Targeted Therapy: A Desert Oasis for Hypertension

While TKIs offer a beacon of hope for patients with MTC, they can also have side effects, like hypertension, that can feel like a sudden sandstorm. This research delves into the mechanisms of drug-induced hypertension, emphasizing the need for careful management and monitoring. The study highlights the need for individualized treatment strategies and suggests future research to explore the link between tumor growth inhibition and hypertension.

Staying Hydrated in the Desert: Managing Hypertension in MTC Treatment

Navigating the treatment of MTC can feel like traversing a vast and unforgiving desert. The study emphasizes the importance of managing hypertension, a potential side effect of TKIs. It's crucial to stay hydrated, both physically and metaphorically, by working closely with your healthcare team to monitor blood pressure and implement strategies to manage this potentially challenging aspect of treatment.

Dr.Camel's Conclusion

The desert of MTC treatment is a complex and ever-changing landscape. While TKIs offer a potential oasis of hope, they come with their own set of challenges. This research provides valuable insights into the use of TKIs in MTC, highlighting their potential benefits and the need for vigilant management of side effects, particularly hypertension. By staying informed and working closely with your healthcare team, you can navigate the treatment journey with greater awareness and confidence.

Date :
  1. Date Completed 2019-01-15
  2. Date Revised 2022-03-25
Further Info :

Pubmed ID

30347815

DOI: Digital Object Identifier

PMC6214082

Related Literature

SNS
PICO Info
in preparation
Languages

English

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