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In Situ Stimulated Raman Scattering (SRS) Microscopy Study of the Dissolution of Sustained-Release Implant Formulation.

Author: ForsterSeth P, FrancisAndrew T, FuDan, KuiperJesse, LammMatthew S, NguyenTai T, RhodesTimothy, SmithRonald L, SuYongchao, TellerRyan, XuWei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Localized drug delivery systems (DDSs) are being developed to provide therapeutic levels of drug while mitigating side effects. This study used stimulated Raman scattering (SRS) microscopy to track the dissolution of entecavir, a hepatitis B antiviral drug, embedded in a slow-release poly(d,l-lactic acid) formulation. The results showed that SRS microscopy can be used to quantitatively profile dissolution of single crystalline particles in implant formulations.
Paper Details　
Original Abstract of the Article :
Localized drug delivery systems (DDSs) provide therapeutic levels of drug agent while mitigating side effects of systemic delivery. These systems offer controlled release over extended periods of time making them attractive therapies. Monitoring drug dissolution is vital for developing safe and effe...See full text at original site
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引用元：
https://doi.org/10.1021/acs.molpharmaceut.8b00965

データ提供：米国国立医学図書館（NLM）

In Situ Stimulated Raman Scattering (SRS) Microscopy Study of Sustained-Release Implant Formulation

This study utilized a cutting-edge technique called stimulated Raman scattering (SRS) microscopy to visualize and quantify the dissolution of a drug within a sustained-release implant formulation. The researchers wanted to understand how drug particles dissolve over time within the implant, which can help improve the design of drug delivery systems.

Visualizing Drug Dissolution with SRS Microscopy

The study successfully demonstrated the ability of SRS microscopy to track the dissolution of individual drug particles within the polymer matrix of the implant. This technology provides detailed information about the dissolution kinetics at a high spatial resolution, offering a deeper understanding of how drugs release from implants.

Improving Drug Delivery Systems

This research highlights the potential of SRS microscopy as a valuable tool for developing and optimizing drug delivery systems. By providing a more detailed understanding of drug dissolution dynamics, we can create more effective and targeted therapies.

Dr. Camel's Conclusion

This study shows the power of SRS microscopy to illuminate the intricate process of drug dissolution within implants. It's like using a powerful magnifying glass to explore the microscopic world of drug release, offering valuable insights for improving the design and efficacy of drug delivery systems.

Date :
  1. Date Completed 2019-09-09
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

30362772

DOI: Digital Object Identifier

10.1021/acs.molpharmaceut.8b00965

Related Literature

Article Analysis
・Side Effects of entecavir
SNS
PICO Info
in preparation
Languages

English

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