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Celastrol strongly inhibits proliferation, migration and cancer stem cell properties through suppression of Pin1 in ovarian cancer cells.
Author: DingJie, LiXiaojing, NieShaozhen, RenShaoda, WangHongmin, WangLi, ZhangLili
Original Abstract of the Article :
Ovarian cancer is one of the most serious diseases worldwide and the fifth-most common cancer among women. Celastrol, extracted from Thunder God Vine, exerts anti-cancer effects on various cancers; however, the mechanism underlying these anti-cancer effects in ovarian cancer needs further investigat...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.ejphar.2018.10.043
データ提供:米国国立医学図書館(NLM)
Celastrol - A Potential Weapon Against Ovarian Cancer
This study investigates the anti-cancer effects of celastrol, a natural compound extracted from Thunder God Vine, on ovarian cancer cells. The researchers found that celastrol significantly inhibited cell proliferation and migration, induced apoptosis, and suppressed the expression of cancer stem cell markers. Further analysis revealed that celastrol exerts its anti-cancer effects by suppressing the expression of Pin1, a protein that plays a key role in regulating cell growth and survival. This research suggests that celastrol holds potential as a novel therapeutic agent for ovarian cancer.
Celastrol - A Powerful Ally in the Fight Against Ovarian Cancer
The study's findings demonstrate the potent anti-cancer effects of celastrol on ovarian cancer cells. Its ability to suppress cell proliferation, induce apoptosis, and inhibit cancer stem cell properties suggests that it could be a valuable addition to the arsenal of treatments for this challenging disease. The study's discovery of Pin1 as a potential target for celastrol opens exciting avenues for further research and development of novel anti-cancer therapies.
Celastrol - A Natural Weapon Against a Devastating Disease
This research highlights the potential of natural compounds, like celastrol, in combating cancer. The discovery of its anti-cancer activity against ovarian cancer is a beacon of hope in the fight against this devastating disease. Think of celastrol as a potent desert plant, drawing strength from the harsh environment to combat the aggressive nature of cancer cells. This research encourages further exploration of natural compounds for their potential to provide effective and safe treatments for cancer.
Dr. Camel's Conclusion
This study reveals the exciting potential of celastrol as a natural weapon against ovarian cancer. Its ability to inhibit cell growth, induce apoptosis, and suppress cancer stem cell properties makes it a promising candidate for further investigation and potential therapeutic development. This research is a testament to the power of nature and the ongoing quest for innovative treatments for challenging diseases.
Date :
- Date Completed 2019-02-25
- Date Revised 2021-12-04
Further Info :
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