Effective treatment of thunder god vine: A Synthesis of Findings from 20 Studies

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Original Abstract of the Article

Major research findings

Thunder god vine (Tripterygium wilfordii) is a traditional Chinese medicine with a long history of use. Recent research has shown that compounds extracted from thunder god vine, such as triptolide and celastrol, have a variety of pharmacological effects, including anti-cancer, anti-inflammatory, and antioxidant properties. 19 、 4 、 15 、 18 、 8

Triptolide has been shown to inhibit the growth of triple-negative breast cancer cells (MDA-MB-231) and induce apoptosis. 19

Dihydro-β-agarofuran-type sesquiterpenoids, extracted from the seeds of thunder god vine, have been shown to suppress osteoclastogenesis. 4

Triptolide has been reported to lead to hepatic intolerance to exogenous lipopolysaccharide (LPS) stimulation and to acute liver failure in mice. 9

Celastrol has been shown to inhibit necroptosis, a type of cell death, and protect against acute pancreatitis in mice. 6

Thunder god vine has also been shown to have immunosuppressive effects and is used in the treatment of autoimmune diseases. 10 、 12

Celastrol has also been shown to suppress the growth and metastasis of colorectal cancer cells. 16

Combining triptolide with celastrol has shown a synergistic effect in inhibiting cancer cell growth. 2

Celastrol has shown potential benefits in preventing and treating obesity. 17 、 13

Celastrol has also been shown to inhibit the growth and metastasis of ovarian cancer cells. 20

Celastrol has been shown to suppress the growth of hepatocellular carcinoma cells. 7

Benefits and Risks

Benefits Summary

Thunder god vine has a variety of pharmacological effects, including anti-cancer, anti-inflammatory, and antioxidant properties. 19 、 4 、 15 、 18 、 8 、 10 、 12 、 16 、 2 、 17 、 13 、 20 、 7

Risks Summary

Triptolide has been reported to lead to hepatic intolerance to exogenous lipopolysaccharide (LPS) stimulation and to acute liver failure in mice. 9

Thunder god vine is used traditionally, but some of its ingredients have been shown to have toxic effects on the liver. 14

Comparison of Research

Commonalities

Many studies have confirmed that the components of thunder god vine have the potential to inhibit cancer cell growth and induce apoptosis. Anti-inflammatory and immunosuppressive effects have also been observed. 19 、 4 、 15 、 18 、 8 、 10 、 12 、 16 、 2 、 17 、 13 、 20 、 7

Differences

Different studies have shown that the types of cancer that can be treated, the effective ingredients, and the mechanisms of action vary. 19 、 4 、 15 、 18 、 8 、 10 、 12 、 16 、 2 、 17 、 13 、 20 、 7

Consistency and Contradictions in Results

Research on the components of thunder god vine has shown potential benefits such as anti-cancer and immunosuppressive effects, but also potential liver toxicity. 9

Cautions in Applying Research to Everyday Life

Thunder god vine is used traditionally, but some of its ingredients have been shown to have toxic effects on the liver. 14

Consult with a medical professional before using products containing thunder god vine. 14

Limitations of Current Research

Further research is needed to fully understand the mechanisms of action and safety of the components of thunder god vine. 9 、 14

Future Research Directions

Further research is needed to fully understand the mechanisms of action and safety of the components of thunder god vine. 9 、 14

Conclusion

Research has shown that thunder god vine has a variety of potential benefits, including anti-cancer, anti-inflammatory, and antioxidant properties. However, some of its ingredients have been shown to have toxic effects on the liver. 19 、 4 、 15 、 18 、 8 、 10 、 12 、 16 、 2 、 17 、 13 、 20 、 7 、 9 、 14

Consult with a medical professional before using products containing thunder god vine. 14

Literature analysis of 20 papers
Positive Content
20
Neutral Content
0
Negative Content
0
Article Type
0
0
1
3
20
1.

The efficacy of traditional Thai massage for the treatment of chronic pain: A systematic review.

Author: KeeratitanontKeattichai, JensenMark P, ChatchawanUraiwan, AuvichayapatParadee

Improved disability
Increased flexibility
Pain reduction
Reduced anxiety
Reduced muscle tension

This systematic review examined the effects of Traditional Thai massage (TTM) on pain intensity and other outcomes in individuals with chronic pain. Six controlled trials showed pre- to post-treatment pain reductions ranging from 25% to 80%. TTM was also associated with improvements in disability, muscle tension, flexibility and anxiety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine.

Author: JiangQi-Wei, ChengKe-Jun, MeiXiao-Long, QiuJian-Ge, ZhangWen-Ji, XueYou-Qiu, QinWu-Ming, YangYang, ZhengDi-Wei, ChenYao, WeiMeng-Ning, ZhangXu, LvMin, ChenMei-Wan, WeiXing, ShiZhi

Apoptosis induction
Cancer cell growth inhibition
Tumor growth inhibition

This study found that the combination of triptolide and celastrol significantly inhibits cancer cell growth in both laboratory and animal models, potentially offering a new treatment option for cancer patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1.

Author: XuHeng, ZhaoHongfang, DingChunyong, JiangDefang, ZhaoZijie, LiYang, DingXiaoyu, GaoJing, ZhouHu, LuoCheng, ChenGuoqiang, ZhangAo, XuYing, ZhangHao

Celastrol derivative
PRDX1 inhibition
Celastrol side effects

Celastrol, a natural product with anti-tumor activity, suffers from severe side effects. This study identifies peroxiredoxin 1 (PRDX1) as a target of Celastrol in colorectal cancer. A new derivative compound, 19-048, with improved potency and selectivity was developed based on the crystal structure of Celastrol-PRDX1. Both Celastrol and 19-048 showed anti-tumor efficacy in vitro and in vivo, highlighting PRDX1 inhibition as a potential therapeutic strategy for colorectal cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Triptolide leads to hepatic intolerance to exogenous lipopolysaccharide and natural-killer-cell mediated hepatocellular damage by inhibiting MHC class I molecules.

Author: ZhangHaoran, YuanZihang, WangJie, TangQianhui, MiaoYingying, YuanZiqiao, HuangXinliang, ZhuYing, NongCheng, ZhangLuyong, JiangZhenzhou, YuQinwei

Hepatitis treatment
Immune response
Hepatotoxicity

This study investigated the immune mechanisms of triptolide (TP)-sensitized hepatocytes and the TP-induced excessive immune response to lipopolysaccharide (LPS) stimulation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Mechanism of action of <i>Tripterygium wilfordii</i> for treatment of idiopathic membranous nephropathy based on network pharmacology.

Author: ShiHonghong, HouYanjuan, SuXiaole, QiaoJun, WangQian, GuoXiaojiao, GaoZhihong, WangLihua

IMN treatment

The study used network pharmacology to investigate the therapeutic targets and pharmacological mechanism of thunder god vine in treating IMN.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Systemic dendrimer delivery of triptolide to tumor-associated macrophages improves anti-tumor efficacy and reduces systemic toxicity in glioblastoma.

Author: LiawKevin, SharmaRishi, SharmaAnjali, SalazarSebastian, Appiani La RosaSantiago, KannanRangaramanujam M

Targeted glioblastoma treatment
Systemic toxicities

This study presents a novel dendrimer-triptolide conjugate that specifically targets tumor-associated macrophages (TAMs) in glioblastoma. The targeted delivery improves TAM phenotype switching and reduces systemic toxicities associated with triptolide.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Detection and quantification of the anti-obesity drug celastrol in murine liver and brain.

Author: De AngelisMeri, SchrieverSonja C, KyriakouEleni, SattlerMichael, MessiasAna C, SchrammKarl-Werner, PflugerPaul T

Anti-obesity
Leptin sensitization

Celastrol, a natural triterpene, has anti-obesity properties, but its accumulation in the brain is unclear. This study demonstrates that intraperitoneal administration of celastrol in mice leads to its accumulation in the brain and hypothalamus, suggesting a possible site of action for its weight-lowering effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Toxicity of traditional Chinese medicine herbal and mineral products.

Author: LiuRunping, LiXiaojiaoyang, HuangNana, FanMengyue, SunRong

TCM treatment
TCM toxicity

This review summarizes the advances in pharmacology and toxicology research of Toxic Traditional Chinese Medicine (TTCM), including Chinese aconite, Arsenic Trioxide, Tripterygium wilfordii Hook f., herbal drugs from Aristolochiaceae Juss. family, and other TCM products.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Celastrol suppresses nitric oxide synthases and the angiogenesis pathway in colorectal cancer.

Author: GaoYanfeng, ZhouShuang, PangLizhi, YangJuechen, LiHan John, HuoXiongwei, QianSteven Y

Colorectal cancer suppression

Celastrol, a natural compound, was found to suppress colorectal cancer cell growth and migration by inhibiting nitric oxide synthase (NOS) activity and angiogenesis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of PGC-1α/GLUT4 axis-mediated glucose consumption.

Author: FangPenghua, HeBiao, YuMei, ShiMingyi, ZhuYan, ZhangZhenwen, BoPing

Anti-obese
Glucose uptake increase
Weight loss

Celastrol, a natural compound, was found to have anti-obesity effects by suppressing fat intake and promoting glucose uptake through AKT and P38 MAPK activation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells.

Author: LiXiaoli, ZhuGuangbei, YaoXintong, WangNing, HuRonghui, KongQingxin, ZhouDuanfang, LongLiangyuan, CaiJiali, ZhouWeiying

Breast Cancer Treatment

Celastrol, a natural compound, has anti-inflammatory and anti-cancer properties. It inhibits PI3K-Akt-mTOR signaling, which is often dysregulated in tumors. This study investigated the mechanisms by which celastrol inhibits mTOR signaling in breast cancer cells.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Triptolide Decreases Cell Proliferation and Induces Cell Death in Triple Negative MDA-MB-231 Breast Cancer Cells.

Author: VargheseElizabeth, SamuelSamson Mathews, VargheseSharon, CheemaSohaila, MamtaniRavinder, BüsselbergDietrich

TNBC Treatment

This study found that triptolide, a di-terpene tri-epoxide isolated from thunder god vine, could be an efficient anticancer agent in the treatment of triple negative breast cancers (TNBCs).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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