Cholestyramine decreases apparent total tract macronutrient digestibility and alters fecal characteristics and metabolites of healthy adult dogs.

Author: AlexanderCeleste, GuardBlake C, SuchodolskiJan S, SwansonKelly S

Paper Details 
Original Abstract of the Article :
Absorption of dietary lipids in the small intestine is dependent on the emulsification by bile acids (BA) and the formation of chylomicrons. Cholestyramine is a common drug used in humans-and potentially dogs-to treat BA malabsorption associated with chronic diarrhea. It is known to bind BA to form ...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396232/

データ提供:米国国立医学図書館(NLM)

Cholestyramine and Macronutrient Digestibility

The digestive system is a complex and fascinating system, and its proper functioning is essential for maintaining health. This study, like a careful exploration of a desert ecosystem, examines the effects of cholestyramine, a medication used to treat bile acid malabsorption, on macronutrient digestibility in healthy adult dogs. The authors meticulously documented the impact of cholestyramine on fecal characteristics, nutrient absorption, and fecal metabolites.

The Impact of Cholestyramine

The researchers found that cholestyramine significantly decreased apparent total tract digestibility of dietary fat and organic matter, leading to increased fecal output. These findings highlight the potential impact of cholestyramine on nutrient absorption and suggest the need for careful monitoring in dogs receiving this medication.

A Balancing Act

While cholestyramine may decrease nutrient digestibility, it also appears to have some beneficial effects on fecal characteristics. The researchers found that cholestyramine led to firmer stools and altered fecal metabolite profiles, suggesting a potential role in managing gastrointestinal health.

Dr. Camel's Conclusion

This study, like a valuable guidebook for desert travelers, provides insights into the impact of cholestyramine on nutrient absorption and fecal characteristics in dogs. The findings emphasize the importance of understanding the potential benefits and risks of this medication and highlight the need for further research to explore its role in managing gastrointestinal health in dogs.

Date :
  1. Date Completed 2019-05-08
  2. Date Revised 2023-10-06
Further Info :

Pubmed ID

30423121

DOI: Digital Object Identifier

PMC6396232

Related Literature

SNS
PICO Info
in preparation
Languages

English

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