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Single dose gentamicin treatment of urinary infections in children.

Author: AbbottG D, FergussonD M, GrimwoodK

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the effectiveness of a single dose of gentamicin to a seven-day course of antibiotics in treating 69 children with urinary tract infections. Both treatments resulted in similar outcomes after six weeks, regardless of the severity or history of infection. However, children with a history of recurrent infections or abnormal imaging were less likely to respond. The single dose treatment was associated with less disruption of the normal bacteria in the rectum and urethra. While patients who didn't respond to the single dose were more likely to experience a relapse, those who received the standard treatment were more likely to get a new infection.
Paper Details　
Original Abstract of the Article :
Sixty-nine children with urinary tract infections were randomly allocated to single dose gentamicin therapy (n = 39) or a seven day course of an appropriate antibiotic (n = 30). During the following six weeks the response to treatments did not differ and this was not altered by the child's clinical ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3045718

データ提供：米国国立医学図書館（NLM）

Urinary Infections in Children: A Single Dose Solution?

Urinary tract infections (UTIs) are a common problem in children, often requiring antibiotics. This study explores the effectiveness of a single dose of gentamicin in treating UTIs compared to a conventional seven-day course of antibiotics. The authors investigated whether a single dose could be just as effective, minimizing the risk of antibiotic resistance and side effects.

Single Dose Therapy: A Balancing Act

The study found that a single dose of gentamicin was as effective as a seven-day course of antibiotics in treating UTIs. However, the authors also noted that children with a history of recurrent infections or radiological abnormalities had a poorer response. This suggests that a single dose may not be suitable for all children with UTIs. Imagine a camel caravan facing a challenging desert landscape, where some camels might need a more substantial provision of water than others. This research emphasizes the need for careful assessment and individualized treatment plans for children with UTIs.

Balancing Treatment Effectiveness and Safety

This study highlights the importance of carefully considering the benefits and risks of different treatment options for UTIs. A single dose of gentamicin offers a potential solution for many children, but its effectiveness may vary depending on individual factors. This research underscores the need for a balanced approach to UTI treatment, striving to achieve effective treatment with minimal side effects. Just as a camel needs a balance of water and food to thrive in the desert, children with UTIs need a treatment plan that carefully balances effectiveness and safety.

Dr.Camel's Conclusion

This study provides valuable insights into the use of a single dose of gentamicin for treating UTIs in children. While a single dose offers a potential solution for many children, its effectiveness may vary depending on individual factors. The authors highlight the importance of careful assessment and individualized treatment plans for children with UTIs, striving to achieve effective treatment with minimal side effects. This research emphasizes the need for a balanced approach to UTI treatment, just as a camel needs a balanced approach to surviving in the desert.
Date :
  1. Date Completed 1988-09-27
  2. Date Revised 2007-11-15
Further Info :

Pubmed ID

3045718

DOI: Digital Object Identifier

3045718

Related Literature

Article Analysis
・Effective treatment of urinary tract infections
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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