Paper Details

  1. Home
  2. Paper Details

Two recombinant human monoclonal antibodies that protect against lethal Andes hantavirus infection in vivo.

Author: AlvarezRaymond, BarriaMaria I, BravoFelipe, CalvoMario, FeldmannHeinz, GarridoJose L, HaddockElaine, PrescottJoseph, RiosecoMaria L, RiquelmeRaul, SalasAlexis, WilliamsonBrandi N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.

Overview

Two monoclonal antibodies, JL16 and MIB22, were isolated that can effectively neutralize Andes hantavirus (ANDV). Both antibodies protected 100% of Syrian hamsters from a lethal challenge dose of ANDV.
Paper Details　
Original Abstract of the Article :
Andes hantavirus (ANDV) is an etiologic agent of hantavirus cardiopulmonary syndrome (HCPS), a severe disease characterized by fever, headache, and gastrointestinal symptoms that may progress to hypotension, pulmonary failure, and cardiac shock that results in a 25 to 40% case-fatality rate. Current...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1126/scitranslmed.aat6420

データ提供：米国国立医学図書館（NLM）

Fighting Hantavirus: A Desert of Hope

Hantavirus, a deadly virus that can cause severe respiratory illness, poses a significant threat to human health. This research explores the potential of monoclonal antibodies (mAbs) as a treatment for Andes hantavirus (ANDV), the causative agent of hantavirus cardiopulmonary syndrome (HCPS). Like a desert explorer seeking a life-saving antidote, researchers developed two mAbs that effectively neutralized ANDV in laboratory settings. Their findings offer hope for a potential treatment for this deadly virus, paving the way for new therapeutic strategies.

A New Weapon Against Hantavirus

The study demonstrated the effectiveness of the two mAbs, JL16 and MIB22, in protecting hamsters from lethal ANDV infection. It's like discovering a hidden spring in the desert, offering a source of life and protection against the harsh environment. This research holds promise for the development of a post-exposure treatment for HCPS, potentially saving lives and reducing the burden of this deadly disease.

The Desert of Viral Infections

The world of viral infections is a vast and challenging desert. This research provides a glimmer of hope for those facing the threat of hantavirus, offering a potential path to protection and recovery.

Dr.Camel's Conclusion

The development of these monoclonal antibodies represents a significant advancement in the fight against hantavirus. It's like finding a precious oasis in the heart of a dangerous desert, offering hope and protection against a deadly threat.

Date :
  1. Date Completed 2019-10-11
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

30463919

DOI: Digital Object Identifier

10.1126/scitranslmed.aat6420

Related Literature

Article Analysis
・Effective treatment of hantavirus infections
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.