Targeting the terminase: An important step forward in the treatment and prophylaxis of human cytomegalovirus infections.

Author: BognerElke, DrachJohn C, GentryBrian G

Paper Details 
Original Abstract of the Article :
A key step in the replication of human cytomegalovirus (HCMV) in the host cell is the generation and packaging of unit-length genomes into preformed capsids. Enzymes required for this process are so-called terminases, first described for double-stranded DNA bacteriophages. The HCMV terminase consist...See full text at original site
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引用元:
https://doi.org/10.1016/j.antiviral.2018.11.005

データ提供:米国国立医学図書館(NLM)

Targeting the Terminase: A Promising Strategy for Human Cytomegalovirus Infections

In the field of [virology], the [development of antiviral therapies] for [human cytomegalovirus (HCMV) infections] remains a critical area of research. This study focuses on the [terminase], a key enzyme involved in [HCMV replication]. The researchers explore the [terminase] as a [potential drug target], reviewing existing [inhibitors] and highlighting its importance in [viral DNA packaging]. The study provides a comprehensive overview of the [terminase's role in HCMV replication] and the potential for [terminase-targeted therapies] in treating and preventing HCMV infections.

A New Frontier in Antiviral Therapy: Targeting the Terminase

This research sheds light on the potential of [terminase inhibitors] as a novel approach to [treating HCMV infections]. The study's findings suggest that [targeting the terminase] could disrupt a critical step in [HCMV replication], leading to [reduced viral load and improved patient outcomes]. This research offers a promising avenue for the development of [effective and targeted antiviral therapies].

Controlling HCMV: The Importance of Antiviral Therapy

This study underscores the importance of [ongoing research and development] in the field of [antiviral therapy] for [HCMV infections]. The findings highlight the potential of [terminase-targeted therapies] to provide [a new weapon in the fight against HCMV], offering hope for better treatment options and improved patient outcomes. It is essential for researchers and clinicians to collaborate to develop [effective and safe antiviral therapies] for this challenging viral infection.

Dr.Camel's Conclusion

Imagine a desert traveler seeking to cross a vast and unforgiving landscape. Similarly, individuals infected with human cytomegalovirus (HCMV) must navigate the treacherous terrain of viral replication. This study, like a skilled desert guide uncovering hidden pathways, explores the potential of targeting the terminase, a key enzyme in HCMV replication. The findings suggest that by blocking the terminase's activity, we can disrupt the virus's ability to spread, paving the way for more effective antiviral therapies and a brighter future for those affected by HCMV infections.
Date :
  1. Date Completed 2020-02-10
  2. Date Revised 2020-02-10
Further Info :

Pubmed ID

30472161

DOI: Digital Object Identifier

10.1016/j.antiviral.2018.11.005

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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