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[Clinical efficacy and pharmacokinetic evaluation of ceftizoxime in neonates and young infants].

Author: FujitaK, In-yakuF, KaeriyamaM, KakehashiH, MuronoK, OkaT, SakataH, YoshiokaH

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Ceftizoxime (CZX) is a cephalosporin antibiotic that was effective in treating perinatal infections in 13 neonates and young infants. The drug was well tolerated and no side effects were observed in 44 cases. Pharmacokinetic studies showed that CZX is able to cross the placenta and enter the fetal circulation.
Paper Details　
Original Abstract of the Article :
Thirteen neonates and young infants, including 5 infants with very low birth weight, were treated with ceftizoxime (CZX) and its clinical efficacy and side effects were evaluated. The ages of the patients ranged from 0 to 96 days, and their body weights ranged from 580 to 5,050 g. Doses given were 2...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://pubmed.ncbi.nlm.nih.gov/3050189

データ提供：米国国立医学図書館（NLM）

Ceftizoxime in Neonates: A Desert Oasis for Newborn Infections

Neonates, like delicate desert flowers, are particularly vulnerable to infections. Ceftizoxime (CZX), a broad-spectrum antibiotic, is often used to treat infections in this population. This research explores the clinical efficacy and pharmacokinetics of CZX in neonates and young infants, seeking to optimize its use and ensure its safety.

CZX: A Safe and Effective Treatment for Neonates

The study, like a careful camel caravan transporting precious cargo, investigated the use of CZX in 13 neonates and young infants, including those with very low birth weight. The results showed that CZX was effective in treating a variety of infections, including sepsis and urinary tract infections. The drug was well tolerated, with no apparent side effects. Pharmacokinetic studies revealed that CZX levels were generally within the therapeutic range, suggesting that the drug was effective and safe for use in this vulnerable population.

Navigating Neonatal Infections: A Desert Journey Requires Caution

This study provides valuable information about the use of CZX in neonates and young infants. It highlights the importance of careful monitoring and dose adjustment to ensure optimal therapeutic outcomes. The study's findings offer a valuable resource for clinicians treating neonatal infections, allowing them to provide safe and effective care for their patients.

Dr. Camel's Conclusion

This study demonstrates the safety and efficacy of ceftizoxime for treating infections in neonates and young infants. The research provides valuable insights into the pharmacokinetics of the drug in this population, guiding clinicians in optimizing treatment regimens and ensuring the best possible outcomes for their patients. As we navigate the challenges of treating infections in vulnerable populations, we must rely on evidence-based medicine and continue to explore ways to improve patient care.

Date :
  1. Date Completed 1988-11-23
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

3050189

DOI: Digital Object Identifier

3050189

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