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Nicotine-sensitive acetylcholine receptors are relevant pharmacological targets for the control of multidrug resistant parasitic nematodes.

Author: CharvetClaude L, CortetJacques, CourtotElise, GuégnardFabrice, NeveuCedric

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Nicotine derivatives were found to be effective in paralyzing a multidrug-resistant field isolate of Haemonchus contortus, suggesting that nicotinic receptors of parasitic nematodes are promising targets for the development of novel anthelmintics.
Paper Details　
Original Abstract of the Article :
The control of parasitic nematodes impacting animal health relies on the use of broad spectrum anthelmintics. However, intensive use of these drugs has led to the selection of resistant parasites in livestock industry. In that respect, there is currently an urgent need for novel compounds able to co...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287576/

データ提供：米国国立医学図書館（NLM）

Nicotine Receptors: A New Target for Nematode Control

Parasitic nematodes, often called roundworms, can cause significant health problems in livestock, posing a major challenge to animal agriculture. This study explores the potential of nicotine receptors as novel targets for controlling multidrug-resistant nematodes. The researchers found that nicotinic derivatives effectively paralyzed a multiple drug-resistant isolate of H. contortus, a common parasitic nematode. They also confirmed that nicotine receptors are preferential targets for nornicotine and anabasine in C. elegans, a model organism. The study highlights the potential of nicotinic receptors as a promising target for developing new anti-parasitic drugs that can overcome resistance to current medications.

A New Oasis in the Desert of Nematode Control

This study reveals a potential breakthrough in the ongoing battle against multidrug-resistant nematodes. By targeting nicotinic receptors, researchers may be able to develop new drugs that effectively control these parasites. This study represents a significant step forward in the fight against nematode infections in livestock.

Navigating the Desert of Parasitic Infections

The study's findings underscore the importance of developing new strategies for controlling parasitic infections, particularly in the face of increasing drug resistance. By exploring novel targets and mechanisms, researchers can contribute to the sustainable management of these infections and improve animal health.

Dr.Camel's Conclusion

This study offers a ray of hope in the desert of nematode control. By targeting nicotine receptors, researchers may be able to develop new, effective treatments that overcome drug resistance. This discovery is a potential oasis in a landscape often plagued by parasitic infections, offering a promising path towards healthier livestock and more sustainable agriculture.

Date :
  1. Date Completed 2019-01-30
  2. Date Revised 2023-10-04
Further Info :

Pubmed ID

30502120

DOI: Digital Object Identifier

PMC6287576

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Languages

English

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