Effects of pyrantel: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Main Research Findings

Pyrantel is an effective antiparasitic drug used to treat a variety of parasitic infections in different animals. These studies show that pyrantel is effective against a variety of parasites in a variety of animals, including dogs, cats, pigs, horses, and humans.

For example, 13 reported that a drug containing pyrantel was effective against Australian paralysis ticks in dogs. Also, 3 reported that pyrantel was effective against cyathostomins in horses. Furthermore, 18 reported that pyrantel was effective against hookworm infections in school-aged children in Laos.

These studies suggest that pyrantel is an effective treatment for a variety of parasitic infections.

Benefits and Risks

Benefit Summary

Pyrantel is an effective treatment for a variety of parasitic infections. It has been shown to be effective against various parasites in various animals, including dogs, cats, pigs, horses, and humans.

Risk Summary

Pyrantel is generally considered a safe drug. However, side effects can occur in some animals. Side effects include vomiting, diarrhea, and loss of appetite. It's important to talk to your veterinarian before using pyrantel.

Comparison Between Studies

Commonalities

These studies all demonstrate the efficacy of pyrantel against parasites. They also suggest that pyrantel is a safe drug.

Differences

These studies differ in the animal species, types of parasites, and methods of pyrantel administration. Therefore, it is not possible to directly compare the results of these studies.

Consistency and Contradictions in Results

These studies show that pyrantel is effective against parasites. However, the safety of pyrantel varies from study to study. Some studies suggest that pyrantel is safe, while others report side effects.

Considerations for Real-World Application

It's essential to use pyrantel as instructed by your veterinarian. Misuse of pyrantel can lead to side effects. Additionally, pyrantel may not be effective against all parasites. Some parasites may be resistant to pyrantel.

Limitations of Current Research

These studies do not investigate the long-term effects of pyrantel. Furthermore, the effects of pyrantel on humans are not fully studied.

Future Research Directions

Further research is needed to clarify the long-term effects of pyrantel, its impact on humans, and the emergence of resistant strains.

Conclusion

Pyrantel appears to be an effective treatment for a variety of parasitic infections. However, further research is necessary to assess its safety. It's important to consult with a veterinarian before using pyrantel.

Literature analysis of 22 papers
Positive Content
20
Neutral Content
1
Negative Content
1
Article Type
1
0
0
0
22
1.

Pyrantel resistance in two herds of donkey in the UK.

Author: LawsonEdwina, BurdenFaith, ElsheikhaHany M

Anthelmintic resistance

This report investigates pyrantel resistance in two donkey herds in the UK. FECRT revealed large-scale resistance in both herds, confirming the presence of pyrantel resistance in donkey populations despite the widespread use of this anthelmintic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Laboratory and field studies to investigate the efficacy of a novel, orally administered combination product containing moxidectin, sarolaner and pyrantel for the prevention of heartworm disease (Dirofilaria immitis) in dogs.

Author: KrydaKristina, SixRobert H, WalshKelly F, HolzmerSusan J, ChapinSara, MahabirSean P, MyersMelanie, InskeepTammy, RuggJady, CundiffBlair, PullinsAleah, UlrichMichael, McCallJohn W, McTierTom L, MaederSteven J

Heartworm prevention

This study evaluated the efficacy and safety of moxidectin in combination with sarolaner and pyrantel for preventing heartworm disease in dogs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled Trial, VeterinaryRandomized controlled trials involving animals. They evaluate the efficacy and safety of treatment methods.

Language : English

3.

Efficacy of selected anthelmintic drugs against cyathostomins in horses in the federal state of Brandenburg, Germany.

Author: FischerJuliane K, HinneyBarbara, DenwoodMatthew J, TraversaDonato, von Samson-HimmelstjernaGeorg, ClausenPeter-Henning

Treats cyathostomins
Anthelmintic resistance

This study assesses anthelmintic resistance in cyathostomins, the most common internal parasites of horses. Ivermectin showed high efficacy with 99.1% of horses having a zero egg count 14 days after treatment. Pyrantel, however, showed evidence of resistance in some farms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Efficacy of a new oral chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against induced ascarid infections in dogs.

Author: BecskeiCsilla, KrydaKristina, ThysMirjan, HolzmerSusan, BowersockLaurel, FernandesTiago, MeyerLeon, ReinemeyerCraig, MahabirSean P

ascarid control

This study evaluated the efficacy of a novel, oral chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio&#8482;) against induced immature adult (L<sub>5</sub>) and adult Toxocara canis, and adult Toxascaris leonina infections in dogs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Field safety and efficacy of an orally administered combination of sarolaner, moxidectin and pyrantel (Simparica Trio<sup>&#174;</sup>) for the prevention of angiostrongylosis in dogs presented as veterinary patients.

Author: BecskeiCsilla, WillesenJakob L, SchnyderManuela, WozniakiewiczMagda, MiroshnikovaNataliya, MahabirSean P

Angiostrongylus vasorum prevention

This study investigated the efficacy and safety of an oral combination of sarolaner, moxidectin, and pyrantel (Simparica Trio) for preventing Angiostrongylus vasorum infection in dogs. A. vasorum is a cardiopulmonary nematode that can cause severe disease in dogs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled Trial, VeterinaryRandomized controlled trials involving animals. They evaluate the efficacy and safety of treatment methods.

Language : English

6.

Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses.

Author: AbbasGhazanfar, GhafarAbdul, HurleyJohn, BauquierJenni, BeasleyAnne, WilkesEdwina J A, JacobsonCaroline, El-HageCharles, CudmoreLucy, CarriganPeter, Tennent-BrownBrett, GauciCharles G, NielsenMartin K, HughesKristopher J, BeveridgeIan, JabbarAbdul

Anthelmintic resistance

This study assesses the efficacy of commonly used anthelmintics against cyathostomins, a group of parasitic nematodes affecting horses. The indiscriminate use of anthelmintics has led to the development of anthelmintic resistance, making it crucial to evaluate the effectiveness of available treatments. The study aims to provide insights into the efficacy of different anthelmintics against cyathostomins in Australian thoroughbred horses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Efficacy of a novel chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against four common tick species infesting dogs in Europe.

Author: BecskeiCsilla, LiebenbergJulian, ThysMirjan, MahabirSean P

tick control

This study evaluated the efficacy of a novel combination of sarolaner, moxidectin and pyrantel against four tick species that commonly infest dogs in Europe.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Efficacy of Simparica Trio™, a novel chewable tablet containing sarolaner, moxidectin and pyrantel, against induced hookworm infections in dogs.

Author: BecskeiCsilla, ThysMirjan, KrydaKristina, MeyerLeon, MartorellSusanna, GeurdenThomas, DreesenLeentje, FernandesTiago, MahabirSean P

hookworm control

This study evaluated the efficacy of a novel, oral chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio&#8482;) against induced larval (L<sub>4</sub>), immature adult (L<sub>5</sub>) and adult Ancylostoma caninum, and adult Uncinaria stenocephala infections in dogs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Nicotine-sensitive acetylcholine receptors are relevant pharmacological targets for the control of multidrug resistant parasitic nematodes.

Author: CharvetClaude L, GuégnardFabrice, CourtotElise, CortetJacques, NeveuCedric

Resistance-breaking anthelmintics

Nicotine derivatives were found to be effective in paralyzing a multidrug-resistant field isolate of Haemonchus contortus, suggesting that nicotinic receptors of parasitic nematodes are promising targets for the development of novel anthelmintics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Electron and video-light microscopy analysis of the in vitro effects of pyrantel pamoate on Giardia lamblia.

Author: CampanatiL, GadelhaA P, Monteiro-LealL H

giardiasis treatment

Pyrantel pamoate, a drug commonly used for helminthic infections, has been found to negatively impact Giardia lamblia trophozoites in vitro. The drug affects flagella beating, cell structure, and cytoplasm, and the effects appear to be irreversible.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Functional genomics in <i>Brugia malayi</i> reveal diverse muscle nAChRs and differences between cholinergic anthelmintics.

Author: VermaSaurabh, KashyapSudhanva Srinivas, RobertsonAlan Patrick, MartinRichard John

Elephantiasis treatment

This study identified four different muscle nicotinic acetylcholine receptors (nAChRs) in the human nematode parasite Brugia malayi. Cholinergic anthelmintics had different selectivities for these receptors, which represent distinguishable drug targets.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

17.

Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species.

Author: BlanchardAlexandra, GuégnardFabrice, CharvetClaude L, CrisfordAnna, CourtotElise, SauvéChristine, HarmacheAbdallah, DuguetThomas, O'ConnorVincent, Castagnone-SerenoPhilippe, ReavesBarbara, WolstenholmeAdrian J, BeechRobin N, Holden-DyeLindy, NeveuCedric

Anthelmintic efficacy

This research investigates the mechanisms of action of cholinergic anthelmintics, such as levamisole and pyrantel, which target acetylcholine receptors (AChRs) in nematode body wall muscles. The study found that the ACR-8 subunit, present in parasitic nematodes, substitutes for LEV-8 in C. elegans L-AChR, highlighting the critical role of ACR-8 in parasitic nematode sensitivity to these drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Validation StudyResearch to assess the validity and reliability of new measurement methods or diagnostic tests.

Language : English

18.

Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos: a randomised, single-blind trial.

Author: MoserWendelin, SayasoneSomphou, XayavongSyda, BounheuangBangon, PuchkovMaxim, HuwylerJörg, HattendorfJan, KeiserJennifer

Hookworm treatment

Albendazole and mebendazole are medications used to treat hookworm infections. This study looked at whether a combination of three medications was more effective than just using two medications.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Pharmacokinetics of Albendazole, Albendazole Sulfoxide, and Albendazole Sulfone Determined from Plasma, Blood, Dried-Blood Spots, and Mitra Samples of Hookworm-Infected Adolescents.

Author: SchulzJessica D, NeodoAnna, CoulibalyJean T, KeiserJennifer

Helminth infection treatment

Microsampling devices, specifically Mitra, showed comparable results to wet samples for analyzing albendazole and its metabolites, demonstrating their suitability for future pharmacokinetic studies in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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