Side effects of frequently used oral antidiabetics on wound healing in vitro.

Author: BachmannH S, BesserM, KoesterV, SeveringA L, StuermerEwa Klara, TerbergerN

Paper Details 
Original Abstract of the Article :
Lifestyle diseases such as diabetes and arteriosclerosis are rising in the increasingly aging society, and the number of patients with daily intake of glucose-lowering medication has also increased. Interestingly, knowledge about oral antidiabetics with regard to wound healing is scarce. Therefore, ...See full text at original site
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引用元:
https://doi.org/10.1007/s00210-018-01597-9

データ提供:米国国立医学図書館(NLM)

Oral Antidiabetics: A Double-Edged Sword in Wound Healing?

In the age of increasing chronic diseases, understanding the impact of medications on various aspects of health is crucial. This study delves into the often-overlooked effects of oral antidiabetics on wound healing. The research employed a combination of in vitro and 3D wound models to assess the effects of four commonly prescribed antidiabetics on human skin cells. The study reveals that metformin, in particular, may have adverse effects on skin cell metabolism and migration, highlighting the importance of considering the potential impact of these medications on wound healing.

Metformin: A Potential Roadblock to Wound Healing

The study sheds light on the potential negative effects of metformin on wound healing. The researchers found that metformin impaired human skin cell function, potentially hindering the body's natural wound repair process. This finding is particularly relevant for individuals with chronic wounds that are not responding to conventional therapies.

Navigating the Landscape of Wound Healing

The research findings suggest that caution should be exercised when using metformin in patients with chronic wounds. The study highlights the importance of a holistic approach to wound management, considering the potential impact of medications on the healing process. Further research is crucial to better understand the interplay between oral antidiabetics and wound healing, paving the way for safer and more effective treatment strategies.

Dr.Camel's Conclusion

This study reminds us that like a camel's journey across a desert, the effects of medications can be complex and multifaceted. Metformin, while beneficial for blood sugar control, may pose challenges to wound healing. Understanding these potential side effects is crucial for optimizing patient care and ensuring a smooth journey towards recovery.

Date :
  1. Date Completed 2019-12-06
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

30535571

DOI: Digital Object Identifier

10.1007/s00210-018-01597-9

SNS
PICO Info
in preparation
Languages

English

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