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Elevated Random Luteinizing Hormone is an Unreliable Indicator for Pubertal Suppression in Girls Treated with Monthly Leuprolide for Idiopathic Central Precocious Puberty

Author: PanamontaOuyporn, WiromratPattara

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated random LH and estradiol concentrations during monthly leuprolide injection in girls with idiopathic central precocious puberty (ICPP) and their associations with pubertal progression and final adult height (FAH).
Paper Details　
Original Abstract of the Article :
Longitudinal data regarding random luteinizing hormone (LH) concentrations in patients with idiopathic central precocious puberty (ICPP) during treatment are limited. Therefore, we sought to evaluate random LH and estradiol concentrations during monthly leuprolide injection and their associations wi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745452/

データ提供：米国国立医学図書館（NLM）

Luteinizing Hormone: A Flawed Indicator for Pubertal Suppression

Idiopathic central precocious puberty (ICPP), an early onset of puberty, presents challenges in managing pubertal development. This study investigated the reliability of random luteinizing hormone (LH) concentrations as an indicator for pubertal suppression in girls treated with monthly leuprolide injections. The researchers meticulously analyzed longitudinal data on LH and estradiol levels in girls with ICPP, evaluating their association with pubertal progression and final adult height (FAH).

The Unreliability of LH: A Deceptive Oasis in Pubertal Management

Contrary to expectations, random LH concentrations proved to be an unreliable indicator for pubertal suppression in girls with ICPP. The study found no consistent correlation between LH levels and pubertal progression or FAH. These findings highlight the limitations of relying solely on random LH measurements in monitoring pubertal suppression and managing ICPP.

Navigating the Complex Terrain of Puberty

This research underscores the need for a more comprehensive approach to managing ICPP, incorporating a range of factors beyond random LH levels. It emphasizes the importance of individualizing treatment strategies based on individual patient needs and response. Like a skilled explorer venturing through a vast desert, clinicians must adapt their approach, relying on a combination of tools and insights to navigate the complexities of pubertal management.

Dr.Camel's Conclusion

The desert of puberty can be a tricky landscape to traverse, especially for those navigating the challenges of ICPP. This study reminds us that relying on a single indicator, like random LH levels, may not be enough. It is a call for a more comprehensive approach, tailored to the unique needs of each individual, ensuring a smoother journey through the complexities of pubertal development.
Date :
  1. Date Completed 2020-02-10
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

30592192

DOI: Digital Object Identifier

PMC6745452

Related Literature

Article Analysis
・Effects of leuprolide injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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