Comparison of the effect of isotretionin and alitretionin on endometriotic implants and serum vascular endothelial growth factor level: an experimental study.

Author: AkbulutKubra, CobanogluUmit, DegerOrhan, GuvenSuleyman, KartCavit, KulaksizDeniz

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To compare the effects of alitretionin and isotretionin on endometrial peritoneal implants and serum vascular endothelial growth factor (VEGF) levels. STUDY DESIGN: Forty-eight female Sprague Dawley rats were used. Initially surgical rat endometriosis model was done. The endometrial impl...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1080/09513590.2018.1526275

データ提供:米国国立医学図書館(NLM)

Isotretinoin and Alitretinoin: A Comparative Study on Endometriosis

The field of [endometriosis treatment] is constantly seeking new and effective therapies for this debilitating condition. This study compares the effects of [isotretinoin] and [alitretinoin] on [endometrial peritoneal implants] and [serum vascular endothelial growth factor (VEGF) levels] in an experimental rat model. The authors investigated the potential of these retinoids to regress [endometriotic lesions].

The study's findings reveal that [isotretinoin] significantly reduced the [volume of peritoneal endometrial implants] in the treated rats, while [alitretinoin] showed no significant effect. This is akin to a desert oasis where a single spring nourishes the surrounding vegetation, while a neighboring area remains barren. The authors, however, observed no significant changes in [histopathological scores] or [serum VEGF levels] between the treatment groups.

The authors conclude that [isotretinoin] exhibits potential as a medical treatment modality for [endometriosis], while [alitretinoin] may not have a potent regressive effect on [endometriotic lesions]. The study highlights the need for further research to investigate the specific mechanisms of action and the long-term efficacy of [isotretinoin] in treating [endometriosis].

Isotretinoin: A Potential Avenue for Endometriosis Treatment

The study's findings offer a glimmer of hope for individuals with [endometriosis]. The researchers observed that [isotretinoin] significantly reduced the [volume of peritoneal endometrial implants] in the treated rats, suggesting its potential as a medical treatment for this condition.

Exploring New Frontiers in Endometriosis Treatment: A Journey Towards Healthier Lives

This research highlights the potential of [isotretinoin] as a medical treatment for [endometriosis]. The study's findings, while preliminary, provide a foundation for further investigation into the specific mechanisms of action and the long-term efficacy of this retinoid in managing this debilitating condition.

Dr. Camel's Conclusion

This study suggests that isotretinoin may offer a potential treatment option for endometriosis, although further research is needed to fully evaluate its efficacy and safety. The study highlights the importance of exploring new therapeutic avenues for this debilitating condition, offering hope for a brighter future for women suffering from endometriosis.

Date :
  1. Date Completed 2019-09-24
  2. Date Revised 2019-09-25
Further Info :

Pubmed ID

30600729

DOI: Digital Object Identifier

10.1080/09513590.2018.1526275

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.