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Gonadotrophins for ovulation induction in women with polycystic ovary syndrome.

Author: KostovaElena, MolBen Willem J, NahuisMarleen, WeissNienke S, van WelyMadelon, van der VeenFulco

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

There may be little or no difference in live birth rates between urinary-derived gonadotrophins and recombinant follicle stimulating hormone (rFSH) in women with polycystic ovary syndrome (PCOS). Gonadotrophins resulted in more live births than continued clomiphene citrate in women with clomiphene citrate failure.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Ovulation induction with follicle stimulating hormone (FSH) is a second-line treatment in women with polycystic ovary syndrome (PCOS) who do not ovulate or conceive on clomiphene citrate. OBJECTIVES: To compare the effectiveness and safety of gonadotrophins as a second-line treatment fo...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353048/

データ提供：米国国立医学図書館（NLM）

Gonadotrophins for Ovulation Induction in Women with Polycystic Ovary Syndrome

This study examines the effectiveness and safety of gonadotrophins for ovulation induction in women with polycystic ovary syndrome (PCOS) who have not responded to clomiphene citrate treatment. The researchers conducted a systematic review and meta-analysis, pooling data from 15 randomized controlled trials involving 2387 women. They compared the efficacy and safety of different types of gonadotrophins, including recombinant follicle-stimulating hormone (rFSH), urinary-derived gonadotrophins, and human menopausal gonadotropin (HMG).

Gonadotrophins and Ovulation Induction

The researchers found that there may be little or no difference in live birth rates between rFSH and urinary-derived gonadotrophins. Similarly, there may be little or no difference in the incidence of multiple pregnancies, clinical pregnancy rates, or miscarriage rates. When comparing HMG or highly purified HMG to urinary follicle-stimulating hormone, the researchers were uncertain about the differences in live birth rates, multiple pregnancy rates, clinical pregnancy rates, or miscarriage rates. The results suggest that gonadotrophins might lead to more live births than continued clomiphene citrate without increasing the incidence of multiple pregnancies.

Personalized Treatment for PCOS

This review highlights the importance of individualizing treatment for PCOS, considering the different responses to various gonadotrophin therapies. It's like a camel caravan preparing for a challenging journey – each camel requires specific gear based on its individual needs. The researchers suggest that cost and convenience should be considered when deciding between different gonadotrophin options.

Dr. Camel's Conclusion

This research provides valuable insights into the use of gonadotrophins for ovulation induction in women with PCOS, emphasizing the need for personalized treatment strategies. It's like a camel caravan navigating a vast and varied desert – a skilled guide knows how to adjust the route and strategies based on the unique challenges of each stage of the journey.

Date :
  1. Date Completed 2019-04-10
  2. Date Revised 2023-04-12
Further Info :

Pubmed ID

30648738

DOI: Digital Object Identifier

PMC6353048

Related Literature

Article Analysis
・Effective treatment of polycystic ovary syndrome
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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