A randomised controlled trial of vaporised &#916;<sup>9</sup>-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute intoxication effects.

Author: BroydSamantha, CroftRodney, GalettisPeter, GreenwoodLisa-Marie, JonesAlison, LiuZheng, MartelozzoDave, MartinJennifer, MichiePatricia T, MurrayRobin, RuebKuna, SolowijNadia, ToddJuanita, van HellHendrika

Paper Details 
Original Abstract of the Article :
Access to cannabis and cannabinoid products is increasing worldwide for recreational and medicinal use. Two primary compounds within cannabis plant matter, &#916;<sup>9</sup>-tetrahydrocannabinol (THC) and cannabidiol (CBD), are both psychoactive, but only THC is considered intoxicating. There is si...See full text at original site
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引用元:
https://doi.org/10.1007/s00406-019-00978-2

データ提供:米国国立医学図書館(NLM)

Cannabinoids: A Complex Relationship Between THC and CBD

The [use of cannabis and cannabinoid products] is becoming increasingly common, both for [recreational and medicinal purposes]. This study investigates the [acute effects of vaporized Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD)] when administered alone and in combination to [frequent and infrequent cannabis users]. The researchers conducted a [randomized, placebo-controlled trial] with [36 participants] and measured [objective and subjective intoxication levels] after different doses of THC and CBD. Their findings suggest that [CBD can both enhance and reduce the intoxicating effects of THC] depending on the dose. This research provides valuable insights into the [complex interplay of THC and CBD] and has implications for [recommended proportions of these compounds] in cannabis products.

THC and CBD: A Balancing Act in Cannabis Products

This study highlights the [potential for CBD to modulate the effects of THC]. It's like a delicate dance between two partners, where each one's actions influence the outcome of the performance. The researchers found that [low doses of CBD can enhance the effects of THC], while [high doses can reduce them]. This finding suggests that [the ratio of THC to CBD in cannabis products] can significantly affect the overall experience of the user.

Navigating the Cannabis Landscape: A Journey of Exploration and Discovery

This research is like a journey through a vast and mysterious desert, where each step reveals new insights into the complex world of cannabinoids. As we continue to explore the therapeutic potential of cannabis, it's essential to understand the nuanced interactions between different compounds and to develop safe and effective products for patients.

Dr. Camel's Conclusion

This research sheds light on the intricate relationship between THC and CBD, demonstrating the power of CBD to both enhance and mitigate the intoxicating effects of THC. It's a reminder that the cannabis landscape is vast and complex, requiring careful navigation and understanding to unlock its full therapeutic potential.

Date :
  1. Date Completed 2019-06-05
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

30661105

DOI: Digital Object Identifier

10.1007/s00406-019-00978-2

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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