Paper Details

  1. Home
  2. Paper Details

Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus-associated syndromes.

Author: AhlmC, BjörkströmN K, KlingströmJ, LjunggrenH G, MalekiK T, Smed-SörensenA, Solà-RieraC

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Hantaviruses cause two severe hyperinflammatory syndromes: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). This study describes recent insights into the generation of immune responses following infection with Puumala virus (PUUV), a common HFRS-causing hantavirus in Europe. The study highlights the redistribution of immune cells to the airways, excessive NK cell activation, and apoptosis resistance in infected cells. These observations may provide new insights into the pathogenesis of hantavirus infections.
Paper Details　
Original Abstract of the Article :
Two related hyperinflammatory syndromes are distinguished following infection of humans with hantaviruses: haemorrhagic fever with renal syndrome (HFRS) seen in Eurasia and hantavirus pulmonary syndrome (HPS) seen in the Americas. Fatality rates are high, up to 10% for HFRS and around 35%-40% for HP...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850289/

データ提供：米国国立医学図書館（NLM）

Unraveling the Immune Response to Puumala Virus Infection

This study delves into the intricate world of the immune response to Puumala virus infection, a topic as complex and layered as the dunes of the Sahara. It explores the mechanisms behind the two severe syndromes caused by hantaviruses: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The authors shed light on the roles of innate and adaptive immune responses, highlighting the importance of NK cells and CD8 T cells in fighting this virus. This research also explores the virus's ability to evade the immune system, a tactic as clever as a desert fox.

A Deeper Understanding of Hantavirus Infection

The research reveals key insights into the immune response to Puumala virus, including the redistribution of immune cells, excessive NK cell activation, and the virus's ability to evade apoptosis. This knowledge can contribute to the development of more effective treatment strategies for these dangerous syndromes.

Hope for the Future

This study provides a foundation for developing novel treatment strategies for severe hantavirus infections. By understanding the intricacies of the immune response, researchers can explore ways to boost the immune system and counter the virus's evasion tactics. This research is a beacon of hope in the fight against these deadly diseases.

Dr.Camel's Conclusion

This research delves into the intricate mechanisms of the immune response to Puumala virus infection, shedding light on the complex interplay between the virus and our immune system. By unraveling these mechanisms, we can pave the way for innovative therapies to combat severe hantavirus syndromes and improve patient outcomes.

Date :
  1. Date Completed 2020-05-07
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

30663801

DOI: Digital Object Identifier

PMC6850289

Related Literature

Article Analysis
・Effective treatment of hantavirus infections
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.