Pharmacology of olsalazine.

Author: BerglindhT, CampbellD E

Paper Details 
Original Abstract of the Article :
In the treatment of inflammatory bowel disease the main anti-inflammatory component of sulphasalazine is 5-ASA. Based on the same azo-splitting principle in the colon as sulphasalazine, the new drug olsalazine was developed. Olsalazine consists of two 5-ASA molecules joined by an azo bridge. Pharmac...See full text at original site
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引用元:
https://doi.org/10.3109/00365528809101539

データ提供:米国国立医学図書館(NLM)

Olsalazine: A New Approach to Ulcerative Colitis

Ulcerative colitis, a chronic inflammatory bowel disease, can feel like a burning fire within the digestive system. This study explored the potential of olsalazine, a new drug for treating ulcerative colitis, as a safe and effective alternative to sulphasalazine. The authors conducted pharmacokinetic and toxicological studies to evaluate the safety and efficacy of olsalazine. Their findings revealed that olsalazine is well-tolerated and delivers twice the amount of 5-ASA, the active anti-inflammatory component, to the colonic mucosa compared to sulphasalazine, without the associated side effects of sulphapyridine.

A Safer and More Effective Treatment

This study presents a promising new treatment for ulcerative colitis. The authors' findings suggest that olsalazine offers a safer and more effective alternative to sulphasalazine, with a higher concentration of the active anti-inflammatory component delivered directly to the affected area.

Managing Ulcerative Colitis

This research highlights the importance of developing new and improved treatments for inflammatory bowel diseases. The authors' findings provide valuable information for healthcare providers in managing ulcerative colitis. Olsalazine emerges as a potential alternative to sulphasalazine, offering a safer and more effective treatment option for patients with this condition.

Dr.Camel's Conclusion

This study, like a refreshing spring in a parched desert, offers a new and promising treatment for ulcerative colitis. It underscores the importance of research and innovation in developing safer and more effective therapies for inflammatory bowel diseases.

Date :
  1. Date Completed 1989-04-04
  2. Date Revised 2019-09-19
Further Info :

Pubmed ID

3067340

DOI: Digital Object Identifier

10.3109/00365528809101539

Related Literature

SNS
PICO Info
in preparation
Languages

English

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