Determining the Effects of Combined Liraglutide and Phentermine on Metabolic Parameters, Blood Pressure, and Heart Rate in Lean and Obese Male Mice.

Author: Buch-RasmussenAlberte S, CowleyMichael A, GroveKevin L, KellyLauren E, KoeglerFrank H, PryorJack T, SimondsStephanie E

Paper Details 
Original Abstract of the Article :
Liraglutide, a glucagon-like peptide 1 (GLP-1) receptor agonist, and phentermine, a psychostimulant structurally related to amphetamine, are drugs approved for the treatment of obesity and hyperphagia. There is significant interest in combination use of liraglutide and phentermine for weight loss; h...See full text at original site
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引用元:
https://doi.org/10.2337/db18-1149

データ提供:米国国立医学図書館(NLM)

Liraglutide and Phentermine: A Powerful Duo for Weight Loss?

The fight against obesity is a complex one, often involving a combination of lifestyle changes and medication. This research explores the potential of combining liraglutide, a glucagon-like peptide 1 (GLP-1) receptor agonist, and phentermine, a psychostimulant, for weight loss. The researchers investigated the effects of these drugs, both individually and in combination, on metabolic parameters, blood pressure, and heart rate in lean and obese mice. Their findings reveal that the combination of liraglutide and phentermine can lead to significant weight loss in both lean and obese mice, but with varying effects on cardiovascular parameters.

A Balancing Act: Weight Loss vs. Cardiovascular Effects

This research suggests that the combination of liraglutide and phentermine can effectively promote weight loss in both lean and obese mice. It's like finding a desert oasis that offers both sustenance and a refreshing respite. However, the study also reveals a nuanced relationship between this drug combination and cardiovascular parameters. The effects on heart rate and blood pressure differed between lean and obese mice, highlighting the importance of considering individual factors when evaluating this treatment approach.

Navigating the Potential Benefits and Risks

This study raises important questions about the potential benefits and risks of combining liraglutide and phentermine for weight loss. It's like exploring a desert landscape, where every step requires careful consideration. The findings suggest that this drug combination can be effective for weight loss, but further research is needed to fully understand its long-term cardiovascular effects. As a camel doctor, I encourage you to consult with your healthcare provider to determine if this treatment approach is appropriate for you.

Dr. Camel's Conclusion

This research explores the potential of combining liraglutide and phentermine for weight loss, suggesting a promising approach for reducing body weight. However, the study also highlights the need for further research to fully understand the cardiovascular implications of this combination. As a camel doctor, I emphasize the importance of personalized care and informed decision-making when considering any weight loss strategies.

Date :
  1. Date Completed 2019-09-17
  2. Date Revised 2019-09-17
Further Info :

Pubmed ID

30674622

DOI: Digital Object Identifier

10.2337/db18-1149

Related Literature

SNS
PICO Info
in preparation
Languages

English

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