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Intravesical Ty21a Vaccine Promotes Dendritic Cells and T Cell-Mediated Tumor Regression in the MB49 Bladder Cancer Model.

Author: ChevalierMathieu F, DerréLaurent, Domingos-PereiraSonia, HaefligerJacques-Antoine, HojeijRim, JichlinskiPatrice, La RosaStefano, MartelPaul, Nardelli-HaefligerDenise, PolákLenka, SathiyanadanKarthik

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the potential of Ty21a/Vivotif, a commercial vaccine against typhoid fever, as an alternative treatment for non-muscle-invasive bladder cancer (NMIBC). The study found that intravesical instillations of Ty21a effectively regressed tumors in a mouse model, mediated by the induction of antitumor adaptive immunity. The findings suggest that Ty21a could be a safe and effective treatment option for NMIBC patients.
Paper Details　
Original Abstract of the Article :
Preclinical data show that intravesical instillation of Ty21a/Vivotif, a commercial vaccine against typhoid fever, is an effective alternative option to standard Bacillus Calmette-Guérin (BCG) immunotherapy for non-muscle-invasive bladder cancer (NMIBC). Here, we characterized the inflammatory ...See full text at original site
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引用元：
https://doi.org/10.1158/2326-6066.CIR-18-0671

データ提供：米国国立医学図書館（NLM）

Ty21a: A Promising Alternative to BCG for Bladder Cancer Immunotherapy

Imagine a desert oasis, a place of healing and restoration. This study explores a novel approach to immunotherapy for non-muscle-invasive bladder cancer (NMIBC), focusing on the potential of Ty21a, a live attenuated typhoid fever vaccine, as an alternative to the standard treatment, Bacillus Calmette-Guérin (BCG). The researchers, like astute desert scientists, investigated the efficacy of Ty21a in a mouse model of bladder cancer, discovering that it significantly improved survival rates and induced a robust immune response. This study reveals a promising potential for Ty21a as a safe and effective immunotherapy for NMIBC, offering a potential alternative to BCG for patients who may not respond well to traditional treatment.

Ty21a: A New Hope for Bladder Cancer Immunotherapy

This study highlights the potential of Ty21a as a safe and effective alternative to BCG for treating non-muscle-invasive bladder cancer. The findings suggest that Ty21a could offer a promising treatment option for patients who may not respond well to BCG immunotherapy.

The Desert of Cancer Treatment: Exploring New Oases of Hope

This study reminds us that the desert of cancer treatment is constantly evolving, with new approaches and discoveries emerging regularly. The potential of Ty21a as a safe and effective immunotherapy for bladder cancer offers a ray of hope for patients seeking alternative treatment options. Just as a camel seeks out a lush oasis in the harsh desert, we must continue to explore new avenues of research and treatment to improve the lives of cancer patients.

Dr.Camel's Conclusion

This study reveals the promising potential of Ty21a as a safe and effective immunotherapy for non-muscle-invasive bladder cancer. The findings offer a beacon of hope for patients seeking alternative treatment options and highlight the importance of ongoing research to develop new and innovative therapies for cancer.

Date :
  1. Date Completed 2020-06-25
  2. Date Revised 2020-06-25
Further Info :

Pubmed ID

30696629

DOI: Digital Object Identifier

10.1158/2326-6066.CIR-18-0671

Related Literature

Article Analysis
・Effects of typhoid vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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